Mechanistic model development of α-lactose monohydrate crystallisation

Jenna Johnston; Cameron Brown; Alastair Florence

Mechanistic model development of α-lactose monohydrate crystallisation

Jenna Johnston, Cameron Brown, Alastair Florence

Research output: Contribution to conference › Poster

30 Downloads (Pure)

Abstract

The aim of this work is to develop a mechanistic model utilising the population balance modelling software gPROMS FormulatedProducts from PSE. The cooling crystallisation kinetics of alpha lactose monohydrate from water have been fitted utilising isothermal seeded desupersaturation experiments under a range of conditions following the method described by Pérez-Calvo, Kadam and Kramer[1]. The development of a robust model that accurately depicting the investigated system allows the model to be used in replacement of copious experiments for optimisation and further investigation into the behaviour of the platform.

Original language	English
Pages	56-56
Number of pages	1
Publication status	Published - 16 May 2022
Event	CMAC Annual Open Day 2022 - Glasgow, United Kingdom Duration: 16 May 2022 → 18 May 2022

Conference

Conference	CMAC Annual Open Day 2022
Country/Territory	United Kingdom
City	Glasgow
Period	16/05/22 → 18/05/22

Keywords

mechanistic model
crystallisation
alpha lactose monohydrate

Access to Document

Johnston-etal-CMAC-2022-Mechanistic-model-development-of-alpha-lactose-monohydrateFinal published version, 1.4 MBLicence: Strath_1

Cite this

@conference{b111f09ada4e4c5cbbd2490f2422db20,

title = "Mechanistic model development of α-lactose monohydrate crystallisation",

abstract = "The aim of this work is to develop a mechanistic model utilising the population balance modelling software gPROMS FormulatedProducts from PSE. The cooling crystallisation kinetics of alpha lactose monohydrate from water have been fitted utilising isothermal seeded desupersaturation experiments under a range of conditions following the method described by P{\'e}rez-Calvo, Kadam and Kramer[1]. The development of a robust model that accurately depicting the investigated system allows the model to be used in replacement of copious experiments for optimisation and further investigation into the behaviour of the platform.",

keywords = "mechanistic model, crystallisation, alpha lactose monohydrate",

author = "Jenna Johnston and Cameron Brown and Alastair Florence",

year = "2022",

month = may,

day = "16",

language = "English",

pages = "56--56",

note = "CMAC Annual Open Day 2022 ; Conference date: 16-05-2022 Through 18-05-2022",

}

TY - CONF

T1 - Mechanistic model development of α-lactose monohydrate crystallisation

AU - Johnston, Jenna

AU - Brown, Cameron

AU - Florence, Alastair

PY - 2022/5/16

Y1 - 2022/5/16

N2 - The aim of this work is to develop a mechanistic model utilising the population balance modelling software gPROMS FormulatedProducts from PSE. The cooling crystallisation kinetics of alpha lactose monohydrate from water have been fitted utilising isothermal seeded desupersaturation experiments under a range of conditions following the method described by Pérez-Calvo, Kadam and Kramer[1]. The development of a robust model that accurately depicting the investigated system allows the model to be used in replacement of copious experiments for optimisation and further investigation into the behaviour of the platform.

AB - The aim of this work is to develop a mechanistic model utilising the population balance modelling software gPROMS FormulatedProducts from PSE. The cooling crystallisation kinetics of alpha lactose monohydrate from water have been fitted utilising isothermal seeded desupersaturation experiments under a range of conditions following the method described by Pérez-Calvo, Kadam and Kramer[1]. The development of a robust model that accurately depicting the investigated system allows the model to be used in replacement of copious experiments for optimisation and further investigation into the behaviour of the platform.

KW - mechanistic model

KW - crystallisation

KW - alpha lactose monohydrate

M3 - Poster

SP - 56

EP - 56

T2 - CMAC Annual Open Day 2022

Y2 - 16 May 2022 through 18 May 2022

ER -

Mechanistic model development of α-lactose monohydrate crystallisation

Abstract

Conference

Keywords

Access to Document

Fingerprint

Cite this