Mechanical behaviour of DNA molecules-elasticity and migration

M. Benke, E. Shapiro, D. Drikakis

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

A novel multi-scale simulation method developed to describe mesoscale phenomena occurring in biofluidic devices is presented. The approach combines the macro-scale modelling of the carrier fluid and the micro-scale description of the transported macromolecules or compounds. Application of the approach is demonstrated through mesoscale simulations of DNA molecules. The investigated phenomena include elastic relaxation of dsDNA molecules and migration of ssDNA molecules in a microchannel flow. The results of the first study demonstrate that the elastic behaviour of the DNA molecules can be captured sucessfully. The second study proves that the migration of ssDNA in pressure-driven microchannel flows can be explained by the hydrodynamic interaction with the carrier liquid.
LanguageEnglish
Pages883-886
Number of pages4
JournalMedical Engineering and Physics
Volume33
Issue number7
DOIs
Publication statusPublished - 30 Sep 2011

Fingerprint

Elasticity
DNA
Molecules
Hydrodynamics
Microchannels
Pressure
Equipment and Supplies
Macromolecules
Macros
Fluids
Liquids

Keywords

  • multi-scale modelling
  • DNA migration
  • DNA elasticity
  • microchannel flows
  • hydrodynamic interaction

Cite this

Benke, M. ; Shapiro, E. ; Drikakis, D. / Mechanical behaviour of DNA molecules-elasticity and migration. In: Medical Engineering and Physics . 2011 ; Vol. 33, No. 7. pp. 883-886.
@article{5c8da63876c7448faf99cc21c26fb9cb,
title = "Mechanical behaviour of DNA molecules-elasticity and migration",
abstract = "A novel multi-scale simulation method developed to describe mesoscale phenomena occurring in biofluidic devices is presented. The approach combines the macro-scale modelling of the carrier fluid and the micro-scale description of the transported macromolecules or compounds. Application of the approach is demonstrated through mesoscale simulations of DNA molecules. The investigated phenomena include elastic relaxation of dsDNA molecules and migration of ssDNA molecules in a microchannel flow. The results of the first study demonstrate that the elastic behaviour of the DNA molecules can be captured sucessfully. The second study proves that the migration of ssDNA in pressure-driven microchannel flows can be explained by the hydrodynamic interaction with the carrier liquid.",
keywords = "multi-scale modelling, DNA migration, DNA elasticity, microchannel flows, hydrodynamic interaction",
author = "M. Benke and E. Shapiro and D. Drikakis",
year = "2011",
month = "9",
day = "30",
doi = "10.1016/j.medengphy.2010.08.003",
language = "English",
volume = "33",
pages = "883--886",
journal = "Medical Engineering and Physics",
issn = "1350-4533",
number = "7",

}

Mechanical behaviour of DNA molecules-elasticity and migration. / Benke, M.; Shapiro, E.; Drikakis, D.

In: Medical Engineering and Physics , Vol. 33, No. 7, 30.09.2011, p. 883-886.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Mechanical behaviour of DNA molecules-elasticity and migration

AU - Benke, M.

AU - Shapiro, E.

AU - Drikakis, D.

PY - 2011/9/30

Y1 - 2011/9/30

N2 - A novel multi-scale simulation method developed to describe mesoscale phenomena occurring in biofluidic devices is presented. The approach combines the macro-scale modelling of the carrier fluid and the micro-scale description of the transported macromolecules or compounds. Application of the approach is demonstrated through mesoscale simulations of DNA molecules. The investigated phenomena include elastic relaxation of dsDNA molecules and migration of ssDNA molecules in a microchannel flow. The results of the first study demonstrate that the elastic behaviour of the DNA molecules can be captured sucessfully. The second study proves that the migration of ssDNA in pressure-driven microchannel flows can be explained by the hydrodynamic interaction with the carrier liquid.

AB - A novel multi-scale simulation method developed to describe mesoscale phenomena occurring in biofluidic devices is presented. The approach combines the macro-scale modelling of the carrier fluid and the micro-scale description of the transported macromolecules or compounds. Application of the approach is demonstrated through mesoscale simulations of DNA molecules. The investigated phenomena include elastic relaxation of dsDNA molecules and migration of ssDNA molecules in a microchannel flow. The results of the first study demonstrate that the elastic behaviour of the DNA molecules can be captured sucessfully. The second study proves that the migration of ssDNA in pressure-driven microchannel flows can be explained by the hydrodynamic interaction with the carrier liquid.

KW - multi-scale modelling

KW - DNA migration

KW - DNA elasticity

KW - microchannel flows

KW - hydrodynamic interaction

UR - http://www.scopus.com/inward/record.url?eid=2-s2.0-79961022144&partnerID=40&md5=f5f3ca04e27e1b967fab6b840e898cc0

U2 - 10.1016/j.medengphy.2010.08.003

DO - 10.1016/j.medengphy.2010.08.003

M3 - Article

VL - 33

SP - 883

EP - 886

JO - Medical Engineering and Physics

T2 - Medical Engineering and Physics

JF - Medical Engineering and Physics

SN - 1350-4533

IS - 7

ER -