Mechanical behaviour of DNA molecules-elasticity and migration

M. Benke, E. Shapiro, D. Drikakis

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

A novel multi-scale simulation method developed to describe mesoscale phenomena occurring in biofluidic devices is presented. The approach combines the macro-scale modelling of the carrier fluid and the micro-scale description of the transported macromolecules or compounds. Application of the approach is demonstrated through mesoscale simulations of DNA molecules. The investigated phenomena include elastic relaxation of dsDNA molecules and migration of ssDNA molecules in a microchannel flow. The results of the first study demonstrate that the elastic behaviour of the DNA molecules can be captured sucessfully. The second study proves that the migration of ssDNA in pressure-driven microchannel flows can be explained by the hydrodynamic interaction with the carrier liquid.
Original languageEnglish
Pages (from-to)883-886
Number of pages4
JournalMedical Engineering and Physics
Volume33
Issue number7
DOIs
Publication statusPublished - 30 Sep 2011

Keywords

  • multi-scale modelling
  • DNA migration
  • DNA elasticity
  • microchannel flows
  • hydrodynamic interaction

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