Measuring induction times and crystal nucleation rates

Clément Brandel, Joop H. ter Horst

Research output: Contribution to journalArticle

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Abstract

A large variation is observed in induction times measured under equal conditions in 1 ml solutions. Ruling out experimental errors, this variation originates from the nucleation process. The induction time distribution is explained by the stochastic nature of nucleation if the number of nuclei formed is approaching 1 per vial. Accurate heterogeneous crystal nucleation rates were determined from the induction time distributions on a 1 ml scale for racemic diprophylline in two solvents. The difference in nucleation behaviour in the two solvents originates from the energy barrier for nucleation, which is much higher in the solvent in which induction times are much longer. In addition the pre-exponential factor for the crystal nucleation rate in both solvents is rather low compared to predictions using Classical Nucleation Theory. Unfortunately, concentration and surface characteristics of the effective heterogeneous particles are not known which clouds a further molecular interpretation.

Original languageEnglish
Pages (from-to)199-214
Number of pages16
JournalFaraday Discussions
Volume179
Early online date27 Jan 2015
DOIs
Publication statusPublished - 2015
EventFaraday Discussion: Nucleation - a Transition State to the Directed Assembly of Materials - Leeds Becket University , Leeds, United Kingdom
Duration: 30 Mar 20151 Apr 2015

Keywords

  • crystal nucleation
  • nucleation process

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  • Activities

    • 1 Key-note speaker and plenary lectures at conferences

    Faraday Discussion: Nucleation - a Transition State to the Directed Assembly of Materials

    Joop Ter Horst (Keynote/plenary speaker)

    31 Mar 2015

    Activity: Participating in or organising an event typesKey-note speaker and plenary lectures at conferences

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