Measuring induction times and crystal nucleation rates

Clément Brandel, Joop H. ter Horst

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

A large variation is observed in induction times measured under equal conditions in 1 ml solutions. Ruling out experimental errors, this variation originates from the nucleation process. The induction time distribution is explained by the stochastic nature of nucleation if the number of nuclei formed is approaching 1 per vial. Accurate heterogeneous crystal nucleation rates were determined from the induction time distributions on a 1 ml scale for racemic diprophylline in two solvents. The difference in nucleation behaviour in the two solvents originates from the energy barrier for nucleation, which is much higher in the solvent in which induction times are much longer. In addition the pre-exponential factor for the crystal nucleation rate in both solvents is rather low compared to predictions using Classical Nucleation Theory. Unfortunately, concentration and surface characteristics of the effective heterogeneous particles are not known which clouds a further molecular interpretation.

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induction
Nucleation
nucleation
Crystals
crystals
Dyphylline
Energy barriers
nuclei
predictions
energy

Keywords

  • crystal nucleation
  • nucleation process

Cite this

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title = "Measuring induction times and crystal nucleation rates",
abstract = "A large variation is observed in induction times measured under equal conditions in 1 ml solutions. Ruling out experimental errors, this variation originates from the nucleation process. The induction time distribution is explained by the stochastic nature of nucleation if the number of nuclei formed is approaching 1 per vial. Accurate heterogeneous crystal nucleation rates were determined from the induction time distributions on a 1 ml scale for racemic diprophylline in two solvents. The difference in nucleation behaviour in the two solvents originates from the energy barrier for nucleation, which is much higher in the solvent in which induction times are much longer. In addition the pre-exponential factor for the crystal nucleation rate in both solvents is rather low compared to predictions using Classical Nucleation Theory. Unfortunately, concentration and surface characteristics of the effective heterogeneous particles are not known which clouds a further molecular interpretation.",
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author = "Cl{\'e}ment Brandel and {ter Horst}, {Joop H.}",
year = "2015",
doi = "10.1039/c4fd00230j",
language = "English",
volume = "179",
pages = "199--214",
journal = "Faraday Discussions",
issn = "1359-6640",

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Measuring induction times and crystal nucleation rates. / Brandel, Clément; ter Horst, Joop H.

In: Faraday Discussions, Vol. 179, 2015, p. 199-214.

Research output: Contribution to journalArticle

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T1 - Measuring induction times and crystal nucleation rates

AU - Brandel, Clément

AU - ter Horst, Joop H.

PY - 2015

Y1 - 2015

N2 - A large variation is observed in induction times measured under equal conditions in 1 ml solutions. Ruling out experimental errors, this variation originates from the nucleation process. The induction time distribution is explained by the stochastic nature of nucleation if the number of nuclei formed is approaching 1 per vial. Accurate heterogeneous crystal nucleation rates were determined from the induction time distributions on a 1 ml scale for racemic diprophylline in two solvents. The difference in nucleation behaviour in the two solvents originates from the energy barrier for nucleation, which is much higher in the solvent in which induction times are much longer. In addition the pre-exponential factor for the crystal nucleation rate in both solvents is rather low compared to predictions using Classical Nucleation Theory. Unfortunately, concentration and surface characteristics of the effective heterogeneous particles are not known which clouds a further molecular interpretation.

AB - A large variation is observed in induction times measured under equal conditions in 1 ml solutions. Ruling out experimental errors, this variation originates from the nucleation process. The induction time distribution is explained by the stochastic nature of nucleation if the number of nuclei formed is approaching 1 per vial. Accurate heterogeneous crystal nucleation rates were determined from the induction time distributions on a 1 ml scale for racemic diprophylline in two solvents. The difference in nucleation behaviour in the two solvents originates from the energy barrier for nucleation, which is much higher in the solvent in which induction times are much longer. In addition the pre-exponential factor for the crystal nucleation rate in both solvents is rather low compared to predictions using Classical Nucleation Theory. Unfortunately, concentration and surface characteristics of the effective heterogeneous particles are not known which clouds a further molecular interpretation.

KW - crystal nucleation

KW - nucleation process

U2 - 10.1039/c4fd00230j

DO - 10.1039/c4fd00230j

M3 - Article

VL - 179

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EP - 214

JO - Faraday Discussions

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SN - 1359-6640

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