Matriptase is a novel initiator of cartilage matrix degradation in osteoarthritis

Jennifer M Milner, Amit Patel, Rose K Davidson, Tracey E Swingler, Antoine Desilets, David A Young, Elizabeth B Kelso, Simon T Donell, Tim E Cawston, Ian M Clark, William R Ferrell, Robin Plevin, John C Lockhart, Richard Leduc, Andrew D Rowan

Research output: Contribution to journalArticlepeer-review

74 Citations (Scopus)


Increasing evidence implicates serine proteinases in pathologic tissue turnover. The aim of this study was to assess the role of the transmembrane serine proteinase matriptase in cartilage destruction in osteoarthritis (OA).
Original languageEnglish
Pages (from-to)1955-1966
Number of pages12
JournalArthritis and Rheumatism
Issue number7
Publication statusPublished - Jul 2010


  • animals
  • cartilage, articular
  • cattle
  • chondrocytes
  • extracellular matrix
  • femoral neck fractures
  • gene expression regulation, enzymologic
  • humans
  • matrix metalloproteinases
  • mice
  • mice, inbred C57BL
  • mice, knockout
  • osteoarthritis, hip
  • proteinase inhibitory proteins, secretory
  • receptor, PAR-2
  • serine endopeptidases


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