Matriptase is a novel initiator of cartilage matrix degradation in osteoarthritis

Jennifer M Milner; Amit Patel; Rose K Davidson; Tracey E Swingler; Antoine Desilets; David A Young; Elizabeth B Kelso; Simon T Donell; Tim E Cawston; Ian M Clark; William R Ferrell; Robin Plevin; John C Lockhart; Richard Leduc; Andrew D Rowan

doi:10.1002/art.27476

Matriptase is a novel initiator of cartilage matrix degradation in osteoarthritis

Jennifer M Milner, Amit Patel, Rose K Davidson, Tracey E Swingler, Antoine Desilets, David A Young, Elizabeth B Kelso, Simon T Donell, Tim E Cawston, Ian M Clark, William R Ferrell, Robin Plevin, John C Lockhart, Richard Leduc, Andrew D Rowan

Research output: Contribution to journal › Article › peer-review

74 Citations (Scopus)

Abstract

Increasing evidence implicates serine proteinases in pathologic tissue turnover. The aim of this study was to assess the role of the transmembrane serine proteinase matriptase in cartilage destruction in osteoarthritis (OA).

Original language	English
Pages (from-to)	1955-1966
Number of pages	12
Journal	Arthritis and Rheumatism
Volume	62
Issue number	7
DOIs	https://doi.org/10.1002/art.27476
Publication status	Published - Jul 2010

Keywords

animals
cartilage, articular
cattle
chondrocytes
extracellular matrix
femoral neck fractures
gene expression regulation, enzymologic
humans
matrix metalloproteinases
mice
mice, inbred C57BL
mice, knockout
osteoarthritis, hip
proteinase inhibitory proteins, secretory
receptor, PAR-2
serine endopeptidases

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Milner, J. M., Patel, A., Davidson, R. K., Swingler, T. E., Desilets, A., Young, D. A., Kelso, E. B., Donell, S. T., Cawston, T. E., Clark, I. M., Ferrell, W. R., Plevin, R., Lockhart, J. C., Leduc, R., & Rowan, A. D. (2010). Matriptase is a novel initiator of cartilage matrix degradation in osteoarthritis. Arthritis and Rheumatism, 62(7), 1955-1966. https://doi.org/10.1002/art.27476

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title = "Matriptase is a novel initiator of cartilage matrix degradation in osteoarthritis",

abstract = "Increasing evidence implicates serine proteinases in pathologic tissue turnover. The aim of this study was to assess the role of the transmembrane serine proteinase matriptase in cartilage destruction in osteoarthritis (OA).",

keywords = "animals, cartilage, articular, cattle, chondrocytes, extracellular matrix, femoral neck fractures, gene expression regulation, enzymologic, humans , matrix metalloproteinases, mice, mice, inbred C57BL, mice, knockout, osteoarthritis, hip, proteinase inhibitory proteins, secretory, receptor, PAR-2, serine endopeptidases",

author = "Milner, {Jennifer M} and Amit Patel and Davidson, {Rose K} and Swingler, {Tracey E} and Antoine Desilets and Young, {David A} and Kelso, {Elizabeth B} and Donell, {Simon T} and Cawston, {Tim E} and Clark, {Ian M} and Ferrell, {William R} and Robin Plevin and Lockhart, {John C} and Richard Leduc and Rowan, {Andrew D}",

year = "2010",

month = jul,

doi = "10.1002/art.27476",

language = "English",

volume = "62",

pages = "1955--1966",

journal = "Arthritis and Rheumatism",

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T1 - Matriptase is a novel initiator of cartilage matrix degradation in osteoarthritis

AU - Milner, Jennifer M

AU - Patel, Amit

AU - Davidson, Rose K

AU - Swingler, Tracey E

AU - Desilets, Antoine

AU - Young, David A

AU - Kelso, Elizabeth B

AU - Donell, Simon T

AU - Cawston, Tim E

AU - Clark, Ian M

AU - Ferrell, William R

AU - Plevin, Robin

AU - Lockhart, John C

AU - Leduc, Richard

AU - Rowan, Andrew D

PY - 2010/7

Y1 - 2010/7

N2 - Increasing evidence implicates serine proteinases in pathologic tissue turnover. The aim of this study was to assess the role of the transmembrane serine proteinase matriptase in cartilage destruction in osteoarthritis (OA).

AB - Increasing evidence implicates serine proteinases in pathologic tissue turnover. The aim of this study was to assess the role of the transmembrane serine proteinase matriptase in cartilage destruction in osteoarthritis (OA).

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KW - cartilage, articular

KW - cattle

KW - chondrocytes

KW - extracellular matrix

KW - femoral neck fractures

KW - gene expression regulation, enzymologic

KW - humans

KW - matrix metalloproteinases

KW - mice

KW - mice, inbred C57BL

KW - mice, knockout

KW - osteoarthritis, hip

KW - proteinase inhibitory proteins, secretory

KW - receptor, PAR-2

KW - serine endopeptidases

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DO - 10.1002/art.27476

M3 - Article

C2 - 20506309

VL - 62

SP - 1955

EP - 1966

JO - Arthritis and Rheumatism

JF - Arthritis and Rheumatism

IS - 7

ER -

Matriptase is a novel initiator of cartilage matrix degradation in osteoarthritis

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Keywords

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