Matriptase is a novel initiator of cartilage matrix degradation in osteoarthritis

Jennifer M Milner, Amit Patel, Rose K Davidson, Tracey E Swingler, Antoine Desilets, David A Young, Elizabeth B Kelso, Simon T Donell, Tim E Cawston, Ian M Clark, William R Ferrell, Robin Plevin, John C Lockhart, Richard Leduc, Andrew D Rowan

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Increasing evidence implicates serine proteinases in pathologic tissue turnover. The aim of this study was to assess the role of the transmembrane serine proteinase matriptase in cartilage destruction in osteoarthritis (OA).
LanguageEnglish
Pages1955-1966
Number of pages12
JournalArthritis and Rheumatism
Volume62
Issue number7
DOIs
Publication statusPublished - Jul 2010

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Serine Proteases
Osteoarthritis
Cartilage
matriptase

Keywords

  • animals
  • cartilage, articular
  • cattle
  • chondrocytes
  • extracellular matrix
  • femoral neck fractures
  • gene expression regulation, enzymologic
  • humans
  • matrix metalloproteinases
  • mice
  • mice, inbred C57BL
  • mice, knockout
  • osteoarthritis, hip
  • proteinase inhibitory proteins, secretory
  • receptor, PAR-2
  • serine endopeptidases

Cite this

Milner, J. M., Patel, A., Davidson, R. K., Swingler, T. E., Desilets, A., Young, D. A., ... Rowan, A. D. (2010). Matriptase is a novel initiator of cartilage matrix degradation in osteoarthritis. Arthritis and Rheumatism, 62(7), 1955-1966. https://doi.org/10.1002/art.27476
Milner, Jennifer M ; Patel, Amit ; Davidson, Rose K ; Swingler, Tracey E ; Desilets, Antoine ; Young, David A ; Kelso, Elizabeth B ; Donell, Simon T ; Cawston, Tim E ; Clark, Ian M ; Ferrell, William R ; Plevin, Robin ; Lockhart, John C ; Leduc, Richard ; Rowan, Andrew D. / Matriptase is a novel initiator of cartilage matrix degradation in osteoarthritis. In: Arthritis and Rheumatism. 2010 ; Vol. 62, No. 7. pp. 1955-1966.
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Milner, JM, Patel, A, Davidson, RK, Swingler, TE, Desilets, A, Young, DA, Kelso, EB, Donell, ST, Cawston, TE, Clark, IM, Ferrell, WR, Plevin, R, Lockhart, JC, Leduc, R & Rowan, AD 2010, 'Matriptase is a novel initiator of cartilage matrix degradation in osteoarthritis' Arthritis and Rheumatism, vol. 62, no. 7, pp. 1955-1966. https://doi.org/10.1002/art.27476

Matriptase is a novel initiator of cartilage matrix degradation in osteoarthritis. / Milner, Jennifer M; Patel, Amit; Davidson, Rose K; Swingler, Tracey E; Desilets, Antoine; Young, David A; Kelso, Elizabeth B; Donell, Simon T; Cawston, Tim E; Clark, Ian M; Ferrell, William R; Plevin, Robin; Lockhart, John C; Leduc, Richard; Rowan, Andrew D.

In: Arthritis and Rheumatism, Vol. 62, No. 7, 07.2010, p. 1955-1966.

Research output: Contribution to journalArticle

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AU - Young, David A

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AU - Donell, Simon T

AU - Cawston, Tim E

AU - Clark, Ian M

AU - Ferrell, William R

AU - Plevin, Robin

AU - Lockhart, John C

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KW - humans

KW - matrix metalloproteinases

KW - mice

KW - mice, inbred C57BL

KW - mice, knockout

KW - osteoarthritis, hip

KW - proteinase inhibitory proteins, secretory

KW - receptor, PAR-2

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