Mathematical insight of methanol toxicity management using charcoal and folinic acid

Sanju Sardar, Priti Kumar Roy, Subhankar Kushary, David Greenhalgh*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contribution book

Abstract

Methanol poisoning is a relatively uncommon yet highly perilous form of intoxication, leading to central nervous system depression, vision impairment, metabolic disruption, and even more deadly consequences if not quickly and effectively addressed. Keeping this in mind, this work primarily studies activated charcoal as first aid for methanolintoxicated persons. In this research article, we initially develop a mathematical model for methanol-enzyme interaction, along with the effects of folate therapy. We consider a unique form of the Dubinin-Astakhov (DA) equation that characterizes the adsorption of methanol on activated charcoal. The impulsive differential equation which we formulate, based on the DA equation, examines the efficacy of activated charcoal in treating methanol toxicity. We also verify all our analytical results using numerical simulations.
Original languageEnglish
Title of host publicationMathematical Analysis and Applications in Biological Phenomena through Modelling
Subtitle of host publicationICMAAM-2023, Kolkata, India, October 9–11
EditorsPriti Kumar Roy, Xianbing Cao, Xue-Zhi Li, Arindam Bhattacharya
Place of PublicationCham
PublisherSpringer
Number of pages11
ISBN (Electronic)9789819791941
ISBN (Print)9789819791934, 9789819791965
Publication statusPublished - 3 Feb 2025
Event2nd International Conference on Mathematical Analysis and Applications in Modelling - Jadavpur University, Kolkata, India
Duration: 9 Oct 202313 Oct 2023
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Conference

Conference2nd International Conference on Mathematical Analysis and Applications in Modelling
Abbreviated titleICAAM2023
Country/TerritoryIndia
CityKolkata
Period9/10/2313/10/23
Internet address

Keywords

  • methanol poisoning
  • activated charcoal
  • folinic acid
  • impulsive differential equation

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