Mast cells and vascular diseases

Simon Kennedy, Junxi Wu, Roger Wadsworth, Catherine Lawrence, Pasquale Maffia

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Mast cells are increasingly being recognized as effector cells in many cardiovascular conditions. Many mast-cell-derived products such as tryptase and chymase can, through their enzymic action, have detrimental effects on blood vessel structure while mast cell-derived mediators such as cytokines and chemokines can perpetuate vascular inflammation. Mice lacking mast cells have been developed and these are providing an insight into how mast cells are involved in cardiovascular diseases and, as knowledge increase, mast cells may become a viable therapeutic target to slow progression of cardiovascular disease
Original languageEnglish
Pages (from-to)53-65
Number of pages13
JournalPharmacology and Therapeutics
Volume138
Issue number1
Early online date16 Jan 2013
DOIs
Publication statusPublished - Apr 2013

Keywords

  • mast cell
  • atherosclerosis
  • restenosis
  • aneurysm
  • vein graft
  • vascular remodeling

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