Mast cell production of IL-4 and TNF may be required for protective and pathological responses in gastrointestinal helminth infection

Michelle X. Ierna, Hannah E. Scales, K.L. Saunders, Catherine E. Lawrence

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Expulsion of the gastrointestinal nematode Trichinella spiralis is associated with Th2 responses and intestinal inflammation, which correlate with a marked mast cell (MC) response. To address the role of MC-derived cytokines in the induction of protective responses, WBB6F1-KitW/KitW-v (W/Wv) mice were reconstituted with wild-type, tumor necrosis factor (TNF)--/-, or interleukin (IL)-4-/- bone marrow (BM) prior to infection with T. spiralis. W/Wv mice reconstituted with TNF--/- or IL-4-/- BM expelled the parasite less efficiently and showed diminished enteropathy, whereas protective responses were normal in W/Wv mice reconstituted with wild-type BM and were accompanied by intestinal pathology. MC responses were reduced in W/Wv mice reconstituted with IL-4-/- BM and to a lesser extent when reconstituted with TNF--/-. These results suggest that MC-derived IL-4 and TNF may regulate the induction of protective Th2 responses and intestinal inflammation associated with the expulsion of T. spiralis. Significantly, these studies suggest a role for MC-derived cytokines as autocrine growth factors.
LanguageEnglish
Pages147-155
Number of pages9
JournalMucosal Immunology
Volume1
DOIs
Publication statusPublished - Jan 2008

Fingerprint

Helminths
Mast Cells
Interleukin-4
Trichinella spiralis
Tumor Necrosis Factor-alpha
Bone Marrow
Infection
Cytokines
Inflammation
Intercellular Signaling Peptides and Proteins
Parasites
Pathology

Keywords

  • mast cells
  • gastrointestinal helminth infection
  • pharmacology
  • biomedical sciences

Cite this

@article{c4917757aa4d476d9b2e8a3752b6c3a8,
title = "Mast cell production of IL-4 and TNF may be required for protective and pathological responses in gastrointestinal helminth infection",
abstract = "Expulsion of the gastrointestinal nematode Trichinella spiralis is associated with Th2 responses and intestinal inflammation, which correlate with a marked mast cell (MC) response. To address the role of MC-derived cytokines in the induction of protective responses, WBB6F1-KitW/KitW-v (W/Wv) mice were reconstituted with wild-type, tumor necrosis factor (TNF)--/-, or interleukin (IL)-4-/- bone marrow (BM) prior to infection with T. spiralis. W/Wv mice reconstituted with TNF--/- or IL-4-/- BM expelled the parasite less efficiently and showed diminished enteropathy, whereas protective responses were normal in W/Wv mice reconstituted with wild-type BM and were accompanied by intestinal pathology. MC responses were reduced in W/Wv mice reconstituted with IL-4-/- BM and to a lesser extent when reconstituted with TNF--/-. These results suggest that MC-derived IL-4 and TNF may regulate the induction of protective Th2 responses and intestinal inflammation associated with the expulsion of T. spiralis. Significantly, these studies suggest a role for MC-derived cytokines as autocrine growth factors.",
keywords = "mast cells, gastrointestinal helminth infection, pharmacology, biomedical sciences",
author = "Ierna, {Michelle X.} and Scales, {Hannah E.} and K.L. Saunders and Lawrence, {Catherine E.}",
year = "2008",
month = "1",
doi = "10.1038/mi.2007.16",
language = "English",
volume = "1",
pages = "147--155",
journal = "Mucosal Immunology",
issn = "1933-0219",

}

Mast cell production of IL-4 and TNF may be required for protective and pathological responses in gastrointestinal helminth infection. / Ierna, Michelle X.; Scales, Hannah E.; Saunders, K.L.; Lawrence, Catherine E.

In: Mucosal Immunology, Vol. 1, 01.2008, p. 147-155.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Mast cell production of IL-4 and TNF may be required for protective and pathological responses in gastrointestinal helminth infection

AU - Ierna, Michelle X.

AU - Scales, Hannah E.

AU - Saunders, K.L.

AU - Lawrence, Catherine E.

PY - 2008/1

Y1 - 2008/1

N2 - Expulsion of the gastrointestinal nematode Trichinella spiralis is associated with Th2 responses and intestinal inflammation, which correlate with a marked mast cell (MC) response. To address the role of MC-derived cytokines in the induction of protective responses, WBB6F1-KitW/KitW-v (W/Wv) mice were reconstituted with wild-type, tumor necrosis factor (TNF)--/-, or interleukin (IL)-4-/- bone marrow (BM) prior to infection with T. spiralis. W/Wv mice reconstituted with TNF--/- or IL-4-/- BM expelled the parasite less efficiently and showed diminished enteropathy, whereas protective responses were normal in W/Wv mice reconstituted with wild-type BM and were accompanied by intestinal pathology. MC responses were reduced in W/Wv mice reconstituted with IL-4-/- BM and to a lesser extent when reconstituted with TNF--/-. These results suggest that MC-derived IL-4 and TNF may regulate the induction of protective Th2 responses and intestinal inflammation associated with the expulsion of T. spiralis. Significantly, these studies suggest a role for MC-derived cytokines as autocrine growth factors.

AB - Expulsion of the gastrointestinal nematode Trichinella spiralis is associated with Th2 responses and intestinal inflammation, which correlate with a marked mast cell (MC) response. To address the role of MC-derived cytokines in the induction of protective responses, WBB6F1-KitW/KitW-v (W/Wv) mice were reconstituted with wild-type, tumor necrosis factor (TNF)--/-, or interleukin (IL)-4-/- bone marrow (BM) prior to infection with T. spiralis. W/Wv mice reconstituted with TNF--/- or IL-4-/- BM expelled the parasite less efficiently and showed diminished enteropathy, whereas protective responses were normal in W/Wv mice reconstituted with wild-type BM and were accompanied by intestinal pathology. MC responses were reduced in W/Wv mice reconstituted with IL-4-/- BM and to a lesser extent when reconstituted with TNF--/-. These results suggest that MC-derived IL-4 and TNF may regulate the induction of protective Th2 responses and intestinal inflammation associated with the expulsion of T. spiralis. Significantly, these studies suggest a role for MC-derived cytokines as autocrine growth factors.

KW - mast cells

KW - gastrointestinal helminth infection

KW - pharmacology

KW - biomedical sciences

U2 - 10.1038/mi.2007.16

DO - 10.1038/mi.2007.16

M3 - Article

VL - 1

SP - 147

EP - 155

JO - Mucosal Immunology

T2 - Mucosal Immunology

JF - Mucosal Immunology

SN - 1933-0219

ER -