Mapping the neuroanatomy of functional decline in Alzheimer's disease from basic to advanced activities of daily living

Andrea Slachevsky, Gonzalo Forno, Paulo Barraza, Eneida Mioshi, Carolina Delgado, Patricia Lillo, Fernando Henriquez, Eduardo Bravo, Mauricio Farias, Carlos Muñoz-Neira, Agustín Ibañez, Mario A. Parra, Michael Hornberger

Research output: Contribution to journalReview article

Abstract

Background
Impairments in activities of daily living (ADL) are a criterion for Alzheimer’s disease (AD) dementia. However, ADL gradually decline in AD, impacting on advanced (a-ADL, complex interpersonal or social functioning), instrumental (IADL, maintaining life in community), and finally basic functions (BADL, activities related to physiological and self-maintenance needs). Information and communication technologies (ICT) have become an increasingly important aspect of daily functioning. Yet, the links of ADL, ICT, and neuropathology of AD dementia are poorly understood. Such knowledge is critical as it can provide biomarker evidence of functional decline in AD.
Methods
ADL were evaluated with the Technology–Activities of Daily Living Questionnaire (T-ADLQ) in 33 patients with AD and 30 controls. ADL were divided in BADL, IADL, and a-ADL. The three domain subscores were covaried against gray matter atrophy via Voxel-Based Morphometry.
Results
Our results showed that three domain subscores of ADL correlate with several brain structures, with a varying degree of overlap between them. BADL score correlated mostly with frontal atrophy, IADL with more widespread frontal, temporal and occipital atrophy and a-ADL with occipital and temporal atrophy. Finally, ICT subscale was associated with atrophy in the precuneus.
Conclusions
The association between ADL domains and neurodegeneration in AD follows a traceable neuropathological pathway which involves different neural networks. This the first evidence of ADL phenotypes in AD characterised by specific patterns of functional decline and well-defined neuropathological changes. The identification of such phenotypes can yield functional biomarkers for dementias such as AD.
LanguageEnglish
Pages1310-1322
Number of pages13
JournalJournal of Neurology
Volume266
Issue number6
Early online date4 Apr 2019
DOIs
Publication statusPublished - 30 Jun 2019

Fingerprint

Neuroanatomy
Activities of Daily Living
Alzheimer Disease
Atrophy
Technology
Dementia
Communication
Biomarkers
Phenotype
Parietal Lobe

Keywords

  • Alzheimer disease
  • functional impairment
  • activities of daily living

Cite this

Slachevsky, A., Forno, G., Barraza, P., Mioshi, E., Delgado, C., Lillo, P., ... Hornberger , M. (2019). Mapping the neuroanatomy of functional decline in Alzheimer's disease from basic to advanced activities of daily living. Journal of Neurology, 266(6), 1310-1322. https://doi.org/10.1007/s00415-019-09260-w
Slachevsky, Andrea ; Forno, Gonzalo ; Barraza, Paulo ; Mioshi, Eneida ; Delgado, Carolina ; Lillo, Patricia ; Henriquez, Fernando ; Bravo, Eduardo ; Farias, Mauricio ; Muñoz-Neira, Carlos ; Ibañez, Agustín ; Parra, Mario A. ; Hornberger , Michael. / Mapping the neuroanatomy of functional decline in Alzheimer's disease from basic to advanced activities of daily living. In: Journal of Neurology. 2019 ; Vol. 266, No. 6. pp. 1310-1322.
@article{aac07623cba946a6a86c4f99dff53912,
title = "Mapping the neuroanatomy of functional decline in Alzheimer's disease from basic to advanced activities of daily living",
abstract = "BackgroundImpairments in activities of daily living (ADL) are a criterion for Alzheimer’s disease (AD) dementia. However, ADL gradually decline in AD, impacting on advanced (a-ADL, complex interpersonal or social functioning), instrumental (IADL, maintaining life in community), and finally basic functions (BADL, activities related to physiological and self-maintenance needs). Information and communication technologies (ICT) have become an increasingly important aspect of daily functioning. Yet, the links of ADL, ICT, and neuropathology of AD dementia are poorly understood. Such knowledge is critical as it can provide biomarker evidence of functional decline in AD. MethodsADL were evaluated with the Technology–Activities of Daily Living Questionnaire (T-ADLQ) in 33 patients with AD and 30 controls. ADL were divided in BADL, IADL, and a-ADL. The three domain subscores were covaried against gray matter atrophy via Voxel-Based Morphometry. ResultsOur results showed that three domain subscores of ADL correlate with several brain structures, with a varying degree of overlap between them. BADL score correlated mostly with frontal atrophy, IADL with more widespread frontal, temporal and occipital atrophy and a-ADL with occipital and temporal atrophy. Finally, ICT subscale was associated with atrophy in the precuneus.ConclusionsThe association between ADL domains and neurodegeneration in AD follows a traceable neuropathological pathway which involves different neural networks. This the first evidence of ADL phenotypes in AD characterised by specific patterns of functional decline and well-defined neuropathological changes. The identification of such phenotypes can yield functional biomarkers for dementias such as AD.",
keywords = "Alzheimer disease, functional impairment, activities of daily living",
author = "Andrea Slachevsky and Gonzalo Forno and Paulo Barraza and Eneida Mioshi and Carolina Delgado and Patricia Lillo and Fernando Henriquez and Eduardo Bravo and Mauricio Farias and Carlos Mu{\~n}oz-Neira and Agust{\'i}n Iba{\~n}ez and Parra, {Mario A.} and Michael Hornberger",
year = "2019",
month = "6",
day = "30",
doi = "10.1007/s00415-019-09260-w",
language = "English",
volume = "266",
pages = "1310--1322",
journal = "Journal of Neurology",
issn = "0340-5354",
number = "6",

}

Slachevsky, A, Forno, G, Barraza, P, Mioshi, E, Delgado, C, Lillo, P, Henriquez, F, Bravo, E, Farias, M, Muñoz-Neira, C, Ibañez, A, Parra, MA & Hornberger , M 2019, 'Mapping the neuroanatomy of functional decline in Alzheimer's disease from basic to advanced activities of daily living' Journal of Neurology, vol. 266, no. 6, pp. 1310-1322. https://doi.org/10.1007/s00415-019-09260-w

Mapping the neuroanatomy of functional decline in Alzheimer's disease from basic to advanced activities of daily living. / Slachevsky, Andrea; Forno, Gonzalo; Barraza, Paulo ; Mioshi, Eneida; Delgado, Carolina; Lillo, Patricia ; Henriquez, Fernando ; Bravo, Eduardo ; Farias, Mauricio; Muñoz-Neira, Carlos ; Ibañez, Agustín; Parra, Mario A.; Hornberger , Michael.

In: Journal of Neurology, Vol. 266, No. 6, 30.06.2019, p. 1310-1322.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Mapping the neuroanatomy of functional decline in Alzheimer's disease from basic to advanced activities of daily living

AU - Slachevsky, Andrea

AU - Forno, Gonzalo

AU - Barraza, Paulo

AU - Mioshi, Eneida

AU - Delgado, Carolina

AU - Lillo, Patricia

AU - Henriquez, Fernando

AU - Bravo, Eduardo

AU - Farias, Mauricio

AU - Muñoz-Neira, Carlos

AU - Ibañez, Agustín

AU - Parra, Mario A.

AU - Hornberger , Michael

PY - 2019/6/30

Y1 - 2019/6/30

N2 - BackgroundImpairments in activities of daily living (ADL) are a criterion for Alzheimer’s disease (AD) dementia. However, ADL gradually decline in AD, impacting on advanced (a-ADL, complex interpersonal or social functioning), instrumental (IADL, maintaining life in community), and finally basic functions (BADL, activities related to physiological and self-maintenance needs). Information and communication technologies (ICT) have become an increasingly important aspect of daily functioning. Yet, the links of ADL, ICT, and neuropathology of AD dementia are poorly understood. Such knowledge is critical as it can provide biomarker evidence of functional decline in AD. MethodsADL were evaluated with the Technology–Activities of Daily Living Questionnaire (T-ADLQ) in 33 patients with AD and 30 controls. ADL were divided in BADL, IADL, and a-ADL. The three domain subscores were covaried against gray matter atrophy via Voxel-Based Morphometry. ResultsOur results showed that three domain subscores of ADL correlate with several brain structures, with a varying degree of overlap between them. BADL score correlated mostly with frontal atrophy, IADL with more widespread frontal, temporal and occipital atrophy and a-ADL with occipital and temporal atrophy. Finally, ICT subscale was associated with atrophy in the precuneus.ConclusionsThe association between ADL domains and neurodegeneration in AD follows a traceable neuropathological pathway which involves different neural networks. This the first evidence of ADL phenotypes in AD characterised by specific patterns of functional decline and well-defined neuropathological changes. The identification of such phenotypes can yield functional biomarkers for dementias such as AD.

AB - BackgroundImpairments in activities of daily living (ADL) are a criterion for Alzheimer’s disease (AD) dementia. However, ADL gradually decline in AD, impacting on advanced (a-ADL, complex interpersonal or social functioning), instrumental (IADL, maintaining life in community), and finally basic functions (BADL, activities related to physiological and self-maintenance needs). Information and communication technologies (ICT) have become an increasingly important aspect of daily functioning. Yet, the links of ADL, ICT, and neuropathology of AD dementia are poorly understood. Such knowledge is critical as it can provide biomarker evidence of functional decline in AD. MethodsADL were evaluated with the Technology–Activities of Daily Living Questionnaire (T-ADLQ) in 33 patients with AD and 30 controls. ADL were divided in BADL, IADL, and a-ADL. The three domain subscores were covaried against gray matter atrophy via Voxel-Based Morphometry. ResultsOur results showed that three domain subscores of ADL correlate with several brain structures, with a varying degree of overlap between them. BADL score correlated mostly with frontal atrophy, IADL with more widespread frontal, temporal and occipital atrophy and a-ADL with occipital and temporal atrophy. Finally, ICT subscale was associated with atrophy in the precuneus.ConclusionsThe association between ADL domains and neurodegeneration in AD follows a traceable neuropathological pathway which involves different neural networks. This the first evidence of ADL phenotypes in AD characterised by specific patterns of functional decline and well-defined neuropathological changes. The identification of such phenotypes can yield functional biomarkers for dementias such as AD.

KW - Alzheimer disease

KW - functional impairment

KW - activities of daily living

UR - https://link.springer.com/journal/volumesAndIssues/415

U2 - 10.1007/s00415-019-09260-w

DO - 10.1007/s00415-019-09260-w

M3 - Review article

VL - 266

SP - 1310

EP - 1322

JO - Journal of Neurology

T2 - Journal of Neurology

JF - Journal of Neurology

SN - 0340-5354

IS - 6

ER -