Mapping the interactions among biomaterials, adsorbed proteins, and human embryonic stem cells

Ying Mei; Sharon Gerecht; Michael Taylor; Andrew J. Urquhart; Said R. Bogatyrev; Seung-Woo Cho; Martyn C. Davies; Morgan R. Alexander; Robert S. Langer; Daniel G. Anderson

doi:10.1002/adma.200803184

Mapping the interactions among biomaterials, adsorbed proteins, and human embryonic stem cells

Ying Mei, Sharon Gerecht, Michael Taylor, Andrew J. Urquhart, Said R. Bogatyrev, Seung-Woo Cho, Martyn C. Davies, Morgan R. Alexander, Robert S. Langer, Daniel G. Anderson

Strathclyde Institute Of Pharmacy And Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

63 Citations (Scopus)

Abstract

An integrated high-throughput polymer synthesis and rapid material/protein/cell interaction assays were developed to optimize stem cell microenvironments. Microarrayed polymers were synthesized and studied for the ability to support the growth of partially differentiated human embryonic stem cells. In parallel, a programmed laser scanning cytometry system was developed to allow for rapid quantification of cell material interaction.

Original language	English
Pages (from-to)	2781-2786
Number of pages	6
Journal	Advanced Materials
Volume	21
Issue number	27
DOIs	https://doi.org/10.1002/adma.200803184
Publication status	Published - 20 Jul 2009

Keywords

cell adhesion
fibronectin activity
high throughput
human embryonic stem cells
polymer array
cell biology

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10.1002/adma.200803184

Physical Organic Chemistry: Opportunities In Synthesis, Materials And Pharmaceuticals (Science And Innovation Award)
Murphy, J. (Principal Investigator), Coombs, G. (Co-investigator), Ferguson, A. (Co-investigator) & Florence, A. (Co-investigator)
Scottish Funding Council SFC, EPSRC (Engineering and Physical Sciences Research Council)
1/09/07 → 30/10/12
Project: Research

Cite this

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abstract = "An integrated high-throughput polymer synthesis and rapid material/protein/cell interaction assays were developed to optimize stem cell microenvironments. Microarrayed polymers were synthesized and studied for the ability to support the growth of partially differentiated human embryonic stem cells. In parallel, a programmed laser scanning cytometry system was developed to allow for rapid quantification of cell material interaction.",

keywords = "cell adhesion, fibronectin activity, high throughput, human embryonic stem cells, polymer array, cell biology",

author = "Ying Mei and Sharon Gerecht and Michael Taylor and Urquhart, {Andrew J.} and Bogatyrev, {Said R.} and Seung-Woo Cho and Davies, {Martyn C.} and Alexander, {Morgan R.} and Langer, {Robert S.} and Anderson, {Daniel G.}",

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AU - Mei, Ying

AU - Gerecht, Sharon

AU - Taylor, Michael

AU - Urquhart, Andrew J.

AU - Bogatyrev, Said R.

AU - Cho, Seung-Woo

AU - Davies, Martyn C.

AU - Alexander, Morgan R.

AU - Langer, Robert S.

AU - Anderson, Daniel G.

PY - 2009/7/20

Y1 - 2009/7/20

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AB - An integrated high-throughput polymer synthesis and rapid material/protein/cell interaction assays were developed to optimize stem cell microenvironments. Microarrayed polymers were synthesized and studied for the ability to support the growth of partially differentiated human embryonic stem cells. In parallel, a programmed laser scanning cytometry system was developed to allow for rapid quantification of cell material interaction.

KW - cell adhesion

KW - fibronectin activity

KW - high throughput

KW - human embryonic stem cells

KW - polymer array

KW - cell biology

U2 - 10.1002/adma.200803184

DO - 10.1002/adma.200803184

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JO - Advanced Materials

JF - Advanced Materials

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ER -

Mapping the interactions among biomaterials, adsorbed proteins, and human embryonic stem cells

Abstract

Keywords

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Projects

Physical Organic Chemistry: Opportunities In Synthesis, Materials And Pharmaceuticals (Science And Innovation Award)

Cite this