Mapping the interactions among biomaterials, adsorbed proteins, and human embryonic stem cells

Ying Mei, Sharon Gerecht, Michael Taylor, Andrew J. Urquhart, Said R. Bogatyrev, Seung-Woo Cho, Martyn C. Davies, Morgan R. Alexander, Robert S. Langer, Daniel G. Anderson

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

An integrated high-throughput polymer synthesis and rapid material/protein/cell interaction assays were developed to optimize stem cell microenvironments. Microarrayed polymers were synthesized and studied for the ability to support the growth of partially differentiated human embryonic stem cells. In parallel, a programmed laser scanning cytometry system was developed to allow for rapid quantification of cell material interaction.
Original languageEnglish
Pages (from-to)2781-2786
Number of pages6
JournalAdvanced Materials
Volume21
Issue number27
DOIs
Publication statusPublished - 20 Jul 2009

Keywords

  • cell adhesion
  • fibronectin activity
  • high throughput
  • human embryonic stem cells
  • polymer array
  • cell biology

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