TY - JOUR
T1 - Major depression and the perception of affective instrumental and expressive gestures
T2 - an fMRI investigation
AU - Sijtsma, Mathilde
AU - Marjoram, Dominic
AU - Gallagher, Helen L.
AU - Grealy, Madeleine A.
AU - Brennan, David
AU - Mathias, Christopher
AU - Cavanagh, Jonathan
AU - Pollick, Frank E.
PY - 2023/12/31
Y1 - 2023/12/31
N2 - Major depressive disorder (MDD) is associated with biased perception of human movement. Gesture is important for communication and in this study we investigated neural correlates of gesture perception in MDD. We hypothesised different neural activity between individuals with MDD and typical individuals when viewing instrumental and expressive gestures that were negatively or positively valenced. Differences were expected in brain areas associated with gesture perception, including superior temporal, frontal, and emotion processing regions. We recruited 12 individuals with MDD and 12 typical controls matched on age, gender, and handedness. They viewed gestures displayed by stick figures while functional magnetic resonance imaging (fMRI) was performed. Results of a random effects three-way mixed ANOVA indicated that individuals with MDD had greater activity in the right claustrum compared to controls, regardless of gesture type or valence. Additionally, we observed main effects of gesture type and valence, regardless of group. Perceiving instrumental compared to expressive gestures was associated with greater activity in the left cuneus and left superior temporal gyrus, while perceiving negative compared to positive gestures was associated with greater activity in the right precuneus and right lingual gyrus. We also observed a two-way interaction between gesture type and valence in various brain regions.
AB - Major depressive disorder (MDD) is associated with biased perception of human movement. Gesture is important for communication and in this study we investigated neural correlates of gesture perception in MDD. We hypothesised different neural activity between individuals with MDD and typical individuals when viewing instrumental and expressive gestures that were negatively or positively valenced. Differences were expected in brain areas associated with gesture perception, including superior temporal, frontal, and emotion processing regions. We recruited 12 individuals with MDD and 12 typical controls matched on age, gender, and handedness. They viewed gestures displayed by stick figures while functional magnetic resonance imaging (fMRI) was performed. Results of a random effects three-way mixed ANOVA indicated that individuals with MDD had greater activity in the right claustrum compared to controls, regardless of gesture type or valence. Additionally, we observed main effects of gesture type and valence, regardless of group. Perceiving instrumental compared to expressive gestures was associated with greater activity in the left cuneus and left superior temporal gyrus, while perceiving negative compared to positive gestures was associated with greater activity in the right precuneus and right lingual gyrus. We also observed a two-way interaction between gesture type and valence in various brain regions.
KW - depression
KW - affective disorders
KW - affect
KW - fMRI
KW - biological motion
KW - gesture perception
U2 - 10.1016/j.pscychresns.2023.111728
DO - 10.1016/j.pscychresns.2023.111728
M3 - Article
SN - 0925-4927
VL - 336
JO - Psychiatry Research: Neuroimaging
JF - Psychiatry Research: Neuroimaging
M1 - 111728
ER -