Major constituents of the predominant endophytic fungi from the nigerian plants bryophyllum pinnatum, morinda lucida and jathropha gossypiifolia

A.A. Sowemimo, R. Edrada-Ebel, R. Ebel, P. Proksch, O.R. Omobuwajo, S.A. Adesanya

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In a chemical screening of fungal strains endophytic to Nigerian plants, Diaporthe phaseolorum, the endophyte of Bryophyllum pinnatum, gave cytochalasin D and (3R,4R)-3,4,5-trihydroxy-1-tetralone, Neurospora discreta from Morinda lucida yielded multiforisin I and 4-hydroxyphenylacetic acid, while Aspergillus japonicus from Jatropha gossypiifolia gave (+)-eupenoxide and microsphaerone C, a new 4-pyridone derivative. When tested for cytotoxic activity, cytochalasin D displayed strong, activity towards the mouse lymphoma cell line L5178Y, while the remaining compounds, except 4-hydroxyphenylacetic acid, were found to be moderately active.
Original languageEnglish
Pages (from-to)1217-1222
Number of pages5
JournalNatural Product Communications
Issue number8
Publication statusPublished - 2008


  • endophytic fungi
  • Diaporthe phaseolorum
  • neurospora discreta
  • aspergillus japonicus
  • microsphaerone C
  • cytotoxicity

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