In a chemical screening of fungal strains endophytic to Nigerian plants, Diaporthe phaseolorum, the endophyte of Bryophyllum pinnatum, gave cytochalasin D and (3R,4R)-3,4,5-trihydroxy-1-tetralone, Neurospora discreta from Morinda lucida yielded multiforisin I and 4-hydroxyphenylacetic acid, while Aspergillus japonicus from Jatropha gossypiifolia gave (+)-eupenoxide and microsphaerone C, a new 4-pyridone derivative. When tested for cytotoxic activity, cytochalasin D displayed strong, activity towards the mouse lymphoma cell line L5178Y, while the remaining compounds, except 4-hydroxyphenylacetic acid, were found to be moderately active.
|Number of pages||5|
|Journal||Natural Product Communications|
|Publication status||Published - 2008|
- endophytic fungi
- Diaporthe phaseolorum
- neurospora discreta
- aspergillus japonicus
- microsphaerone C
Sowemimo, A. A., Edrada-Ebel, R., Ebel, R., Proksch, P., Omobuwajo, O. R., & Adesanya, S. A. (2008). Major constituents of the predominant endophytic fungi from the nigerian plants bryophyllum pinnatum, morinda lucida and jathropha gossypiifolia. Natural Product Communications, 3(8), 1217-1222.