Projects per year
Abstract
Ligand domin(o)ated: In contrast to the straightforward deprotonation of benzothiazole using Grignard reagents, treatment of benzothiazole with 1 leads to a novel type of activation. The initial magnesiation initiates an unstoppable domino reaction of CC coupling, ring opening, nucleophilic addition, and deprotonation to give 2. THF=tetrahydrofuran.
Original language | English |
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Pages (from-to) | 9857-9860 |
Number of pages | 4 |
Journal | Angewandte Chemie |
Volume | 50 |
Issue number | 42 |
DOIs | |
Publication status | Published - 10 Oct 2011 |
Keywords
- cascade reactions
- heterocylces
- magnesium
- metalation
- mixed-metal chemistry
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Dive into the research topics of 'Magnesium-mediated benzothiazole activation: a room temperature cascade of C-H deprotonation, C-C coupling, ring-opening and nucleophilic addition reactions'. Together they form a unique fingerprint.Projects
- 1 Finished
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Physical Organic Chemistry: Opportunities In Synthesis, Materials And Pharmaceuticals (Science And Innovation Award)
Murphy, J. (Principal Investigator), Coombs, G. (Co-investigator), Ferguson, A. (Co-investigator) & Florence, A. (Co-investigator)
Scottish Funding Council SFC, EPSRC (Engineering and Physical Sciences Research Council)
1/09/07 → 30/10/12
Project: Research