Magnesium-mediated arylation of amines via C-F bond activation of fluoroarenes

Leonie J. Bole, Laia Davin, Alan R. Kennedy, Ross McLellan, Eva Hevia

Research output: Contribution to journalArticle

Abstract

A series of new Mg(II) amides featuring a bulky β-diketiminate backstop ligand, has been synthesised. These complexes are demonstrated to be excellent sources of nucleophilic amides that can participate in rapid C–F activation of several fluoroarenes at room temperature or using microwave assistance, leading to the installment of synthetically important C–N bonds via nucleophilic substitution.
Original languageEnglish
Pages (from-to)4339-4342
Number of pages4
JournalChemical Communications
Volume55
Issue number30
DOIs
Publication statusPublished - 13 Mar 2019

Fingerprint

Amides
Magnesium
amides
Amines
magnesium
amines
Chemical activation
activation
Substitution reactions
Ligands
Microwaves
substitutes
microwaves
ligands
room temperature
Temperature

Keywords

  • Fluorinated aromatic molecules
  • medicinal chemistry
  • Magnesium-mediated arylation

Cite this

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Magnesium-mediated arylation of amines via C-F bond activation of fluoroarenes. / Bole, Leonie J.; Davin, Laia; Kennedy, Alan R.; McLellan, Ross; Hevia, Eva.

In: Chemical Communications, Vol. 55, No. 30, 13.03.2019, p. 4339-4342.

Research output: Contribution to journalArticle

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T1 - Magnesium-mediated arylation of amines via C-F bond activation of fluoroarenes

AU - Bole, Leonie J.

AU - Davin, Laia

AU - Kennedy, Alan R.

AU - McLellan, Ross

AU - Hevia, Eva

PY - 2019/3/13

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AB - A series of new Mg(II) amides featuring a bulky β-diketiminate backstop ligand, has been synthesised. These complexes are demonstrated to be excellent sources of nucleophilic amides that can participate in rapid C–F activation of several fluoroarenes at room temperature or using microwave assistance, leading to the installment of synthetically important C–N bonds via nucleophilic substitution.

KW - Fluorinated aromatic molecules

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KW - Magnesium-mediated arylation

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