Magnesium-mediated arylation of amines via C-F bond activation of fluoroarenes

Leonie J. Bole, Laia Davin, Alan R. Kennedy, Ross McLellan, Eva Hevia

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5 Citations (Scopus)
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A series of new Mg(II) amides featuring a bulky β-diketiminate backstop ligand, has been synthesised. These complexes are demonstrated to be excellent sources of nucleophilic amides that can participate in rapid C–F activation of several fluoroarenes at room temperature or using microwave assistance, leading to the installment of synthetically important C–N bonds via nucleophilic substitution.
Original languageEnglish
Pages (from-to)4339-4342
Number of pages4
JournalChemical Communications
Issue number30
Publication statusPublished - 13 Mar 2019


  • Fluorinated aromatic molecules
  • medicinal chemistry
  • Magnesium-mediated arylation


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