Abstract
The biological actions of the lysolipid agonists sphingosine 1-phosphate and lysophosphatidic acid, in addition to other bioactive lipid phosphates such as phosphatidic acid and ceramide 1-phosphate, can be influenced by a family of lipid phosphate phosphatases (LPP), including LPP1, LPP2, LPP3, the Drosophila homologues Wunen (Wun) and Wunen2 (Wun2) and sphingosine 1-phosphate phosphatases 1 and 2 (SPP1, SPP2). This review describes the characteristic of these enzymes and their potential physiological roles in regulating intracellular and extracellular actions and amounts of these lipids in addition to the involvement of these phosphatases in development.
Original language | English |
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Pages (from-to) | 491-501 |
Number of pages | 11 |
Journal | Seminars in Cell and Developmental Biology |
Volume | 15 |
Issue number | 5 |
Early online date | 1 Jul 2004 |
DOIs | |
Publication status | Published - Oct 2004 |
Keywords
- animals
- humans
- lysophospholipids
- membrane proteins
- phosphatidate phosphatase
- phosphoric monoester hydrolases
- protein structure, tertiary
- receptors, G-protein-coupled
- sphingosine