Lysophosphatidic acid and sphingosine 1-phosphate biology: the role of lipid phosphate phosphatases

Susan Pyne, Kok-Choi Kong, Peter I Darroch

Research output: Contribution to journalArticle

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Abstract

The biological actions of the lysolipid agonists sphingosine 1-phosphate and lysophosphatidic acid, in addition to other bioactive lipid phosphates such as phosphatidic acid and ceramide 1-phosphate, can be influenced by a family of lipid phosphate phosphatases (LPP), including LPP1, LPP2, LPP3, the Drosophila homologues Wunen (Wun) and Wunen2 (Wun2) and sphingosine 1-phosphate phosphatases 1 and 2 (SPP1, SPP2). This review describes the characteristic of these enzymes and their potential physiological roles in regulating intracellular and extracellular actions and amounts of these lipids in addition to the involvement of these phosphatases in development.

LanguageEnglish
Pages491-501
Number of pages11
JournalSeminars in Cell and Developmental Biology
Volume15
Issue number5
Early online date1 Jul 2004
DOIs
Publication statusPublished - Oct 2004

Fingerprint

Lipids
Phosphatidic Acids
Phosphoric Monoester Hydrolases
Drosophila
Phosphates
Enzymes
lysophosphatidic acid
sphingosine 1-phosphate
lipid phosphate phosphatase
sphingosine-1-phosphate phosphatase
ceramide 1-phosphate

Keywords

  • animals
  • humans
  • lysophospholipids
  • membrane proteins
  • phosphatidate phosphatase
  • phosphoric monoester hydrolases
  • protein structure, tertiary
  • receptors, G-protein-coupled
  • sphingosine

Cite this

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Lysophosphatidic acid and sphingosine 1-phosphate biology : the role of lipid phosphate phosphatases. / Pyne, Susan; Kong, Kok-Choi; Darroch, Peter I.

In: Seminars in Cell and Developmental Biology , Vol. 15, No. 5, 10.2004, p. 491-501.

Research output: Contribution to journalArticle

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AB - The biological actions of the lysolipid agonists sphingosine 1-phosphate and lysophosphatidic acid, in addition to other bioactive lipid phosphates such as phosphatidic acid and ceramide 1-phosphate, can be influenced by a family of lipid phosphate phosphatases (LPP), including LPP1, LPP2, LPP3, the Drosophila homologues Wunen (Wun) and Wunen2 (Wun2) and sphingosine 1-phosphate phosphatases 1 and 2 (SPP1, SPP2). This review describes the characteristic of these enzymes and their potential physiological roles in regulating intracellular and extracellular actions and amounts of these lipids in addition to the involvement of these phosphatases in development.

KW - animals

KW - humans

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