Lysophosphatidic acid and sphingosine 1-phosphate biology: the role of lipid phosphate phosphatases

Susan Pyne, Kok-Choi Kong, Peter I Darroch

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The biological actions of the lysolipid agonists sphingosine 1-phosphate and lysophosphatidic acid, in addition to other bioactive lipid phosphates such as phosphatidic acid and ceramide 1-phosphate, can be influenced by a family of lipid phosphate phosphatases (LPP), including LPP1, LPP2, LPP3, the Drosophila homologues Wunen (Wun) and Wunen2 (Wun2) and sphingosine 1-phosphate phosphatases 1 and 2 (SPP1, SPP2). This review describes the characteristic of these enzymes and their potential physiological roles in regulating intracellular and extracellular actions and amounts of these lipids in addition to the involvement of these phosphatases in development.

Original languageEnglish
Pages (from-to)491-501
Number of pages11
JournalSeminars in Cell and Developmental Biology
Issue number5
Early online date1 Jul 2004
Publication statusPublished - Oct 2004


  • animals
  • humans
  • lysophospholipids
  • membrane proteins
  • phosphatidate phosphatase
  • phosphoric monoester hydrolases
  • protein structure, tertiary
  • receptors, G-protein-coupled
  • sphingosine

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