Long-range surface plasmon resonance imaging for bioaffinity sensing

A.W. Wark, H.J. Lee, R.M. Corn

Research output: Contribution to journalArticle

191 Citations (Scopus)

Abstract

A novel bioaffinity sensor based on surface plasmon resonance (SPR) imaging measurements of a multiple-layered structure that supports the generation of long-range surface plasmons (LRSPs) at the water−metal interface is reported. LRSPs possess longer surface propagation lengths, higher electric field strengths, and sharper angular resonance curves than conventional surface plasmons. LRSPR imaging is a version of SPR imaging that requires a symmetric dielectric arrangement around the gold thin film. This arrangement is created using an SF10 prism/Cytop/gold/water multilayer film structure where Cytop is an amorphous fluoropolymer with a refractive index very close to that of water. LRSPR imaging experiments are performed at a fixed incident angle and lead to an enhanced response for the detection of surface binding interactions. As an example, the hybridization adsorption of a 16-mer single-stranded DNA (ssDNA) onto a two-component ssDNA array was monitored with LRSPR imaging. The ssDNA array was created using a new fabrication technology appropriate for the LRSPR multilayers.
LanguageEnglish
Pages3904-3907
Number of pages4
JournalAnalytical Chemistry
Volume77
Issue number13
Early online date7 May 2005
DOIs
Publication statusPublished - 2005

Fingerprint

Surface plasmon resonance
Plasmons
Single-Stranded DNA
Imaging techniques
Gold
Water
Fluorine containing polymers
Multilayer films
Prisms
Refractive index
Multilayers
Metals
Electric fields
Adsorption
Fabrication
Thin films
Sensors
Experiments

Keywords

  • surface plasmon resonance
  • long-range surface plasmons
  • LRSPs
  • imaging
  • bioaffinity sensors

Cite this

Wark, A.W. ; Lee, H.J. ; Corn, R.M. / Long-range surface plasmon resonance imaging for bioaffinity sensing. In: Analytical Chemistry. 2005 ; Vol. 77, No. 13. pp. 3904-3907.
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Long-range surface plasmon resonance imaging for bioaffinity sensing. / Wark, A.W.; Lee, H.J.; Corn, R.M.

In: Analytical Chemistry, Vol. 77, No. 13, 2005, p. 3904-3907.

Research output: Contribution to journalArticle

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AU - Corn, R.M.

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AB - A novel bioaffinity sensor based on surface plasmon resonance (SPR) imaging measurements of a multiple-layered structure that supports the generation of long-range surface plasmons (LRSPs) at the water−metal interface is reported. LRSPs possess longer surface propagation lengths, higher electric field strengths, and sharper angular resonance curves than conventional surface plasmons. LRSPR imaging is a version of SPR imaging that requires a symmetric dielectric arrangement around the gold thin film. This arrangement is created using an SF10 prism/Cytop/gold/water multilayer film structure where Cytop is an amorphous fluoropolymer with a refractive index very close to that of water. LRSPR imaging experiments are performed at a fixed incident angle and lead to an enhanced response for the detection of surface binding interactions. As an example, the hybridization adsorption of a 16-mer single-stranded DNA (ssDNA) onto a two-component ssDNA array was monitored with LRSPR imaging. The ssDNA array was created using a new fabrication technology appropriate for the LRSPR multilayers.

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