Locally advanced and metastatic prostate cancer treated with intermittent androgen monotherapy or maximal androgen blockade: results from a randomised phase 3 study by the South European uroncological group

Fernando Calais da Silva, Fernando Manuel Calais da Silva, Frederico Gonçalves, Américo Santos, Jan Kliment, Peter Whelan, Tim Oliver, Nicos Antoniou, Spiro Pastidis, Anton Marques Queimadelos, Chris Robertson

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Abstract

Background: Few randomised studieshave compared antiandrogen intermittent hormonal therapy (IHT) with continuousmaximal androgen blockade (MAB) therapy for advanced prostate cancer (PCa).

Objective: To determine whetheroverall survival (OS) on IHT (cyproterone acetate; CPA) is noninferior to OS oncontinuous MAB.

Design, setting, and participants:This phase 3 randomised trial compared IHT and continuous MAB in patients withlocally advanced or metastatic PCa.

Intervention: During induction,patients received CPA 200 mg/d for 2 wk and then monthly depot injections of aluteinising hormone-releasing hormone (LHRH; triptoreline 11.25 mg) analogueplus CPA 200 mg/d. Patients whose prostate-specific antigen (PSA) was <4ng/ml after 3 mo of induction treatment were randomised to the IHT arm (stoppedtreatment and restarted on CPA 300 mg/d monotherapy if PSA rose to ≥20 ng/ml orthey were symptomatic) or the continuous arm (CPA 200 mg/d plus monthly LHRHanalogue).

Outcome measurements and statistical analysis: Primary outcome measurement was OS. Secondary outcomesincluded cause-specific survival, time to subjective or objective progression,and quality of life. Time off therapy in the intermittent arm was recorded.

Results and limitations: Werecruited 1045 patients, of which 918 responded to induction therapy and wererandomised (462 to IHT and 456 to continuous MAB). OS was similar betweengroups (p=0.25), and noninferiority of IHT was demonstrated (hazard ratio [HR]:0.90; 95% confidence interval [CI], 0.76-1.07). There was a trend for aninteraction between PSA and treatment (p=0.05), favouring IHT over continuoustherapy in patients with PSA ≤1 ng/ml (HR: 0.79; 95% CI, 0.61-1.02). Men treatedwith IHT reported better sexual function. Among the 462 patients on IHT, 50%and 28% of patients were off therapy for ≥2.5 yr or >5 yr, respectively,after randomisation. The main limitation is that the length of time for thetrial to mature means that other therapies are now available. A secondlimitation is that T3 patients may now profit from watchful waiting instead ofandrogen-deprivation therapy.

Conclusions: Noninferiority of IHTin terms of survival and its association with better sexual activity thancontinuous therapy suggest that IHT should be considered for use in routineclinical practice.

Original languageEnglish
Pages (from-to)232-239
Number of pages8
JournalEuropean Urology
Volume66
Issue number2
Early online date4 Apr 2013
DOIs
Publication statusPublished - Aug 2014

Keywords

  • maximal androgen blockade
  • intermittent antiandrogen therapy
  • prostate cancer
  • cyproterone acetate
  • prostate specific antigen
  • triptorelin

Cite this

Calais da Silva, F., Calais da Silva, F. M., Gonçalves, F., Santos, A., Kliment, J., Whelan, P., Oliver, T., Antoniou, N., Pastidis, S., Marques Queimadelos, A., & Robertson, C. (2014). Locally advanced and metastatic prostate cancer treated with intermittent androgen monotherapy or maximal androgen blockade: results from a randomised phase 3 study by the South European uroncological group. European Urology, 66(2), 232-239. https://doi.org/10.1016/j.eururo.2013.03.055