Live chicken egg embryos as an alternative in vivo tumour model for deep surface enhanced Raman spectroscopy

Samantha M. McCabe; Hannah Gardiner; Calum Mullen; Gregory Q. Wallace; Neil C. Shand; Alexander B. Mullen; Linda Horan; Duncan Graham; Karen Faulds; Marie Boyd

doi:10.1039/d4an00617h

Live chicken egg embryos as an alternative in vivo tumour model for deep surface enhanced Raman spectroscopy

Samantha M. McCabe, Hannah Gardiner, Calum Mullen, Gregory Q. Wallace, Neil C. Shand, Alexander B. Mullen, Linda Horan, Duncan Graham, Karen Faulds^*, Marie Boyd^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

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Abstract

Live chicken egg embryos offer new opportunities for evaluation and continuous monitoring of tumour growth for in vivo studies compared to traditional rodent models. Here, we report the first use of surface enhanced Raman scattering (SERS) mapping and surface enhanced spatially offset Raman scattering (SESORS) for the detection and localisation of targeted gold nanoparticles in live chicken egg embryos bearing a glioblastoma tumour.

Original language	English
Pages (from-to)	3513-3517
Number of pages	5
Journal	Analyst
Volume	149
Issue number	13
Early online date	4 Jun 2024
DOIs	https://doi.org/10.1039/d4an00617h
Publication status	Published - Jul 2024

Funding

We thank the University of Strathclyde and DSTL for the financial support. S. M. M., D. G., and K. F. thank DSTL for the funding that supported this work. D. G., K. F., and G. Q. W. acknowledge support from the Leverhulme Trust, RPG-2020-400. M. B. acknowledges the support from the NC3Rs, NCW001055/1.

Keywords

tumour model
Raman spectroscopy
chicken egg embryos
glioblastoma

Access to Document

10.1039/d4an00617hLicence: CC BY 3.0

McCabe-etal-Analyst-2024-Live-chicken-egg-embryos-as-an-alternative-in-vivo-tumour-modelFinal published version, 2.21 MBLicence: CC BY 3.0

Cite this

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title = "Live chicken egg embryos as an alternative in vivo tumour model for deep surface enhanced Raman spectroscopy",

abstract = "Live chicken egg embryos offer new opportunities for evaluation and continuous monitoring of tumour growth for in vivo studies compared to traditional rodent models. Here, we report the first use of surface enhanced Raman scattering (SERS) mapping and surface enhanced spatially offset Raman scattering (SESORS) for the detection and localisation of targeted gold nanoparticles in live chicken egg embryos bearing a glioblastoma tumour.",

keywords = "tumour model, Raman spectroscopy, chicken egg embryos, glioblastoma",

author = "McCabe, {Samantha M.} and Hannah Gardiner and Calum Mullen and Wallace, {Gregory Q.} and Shand, {Neil C.} and Mullen, {Alexander B.} and Linda Horan and Duncan Graham and Karen Faulds and Marie Boyd",

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AU - McCabe, Samantha M.

AU - Gardiner, Hannah

AU - Mullen, Calum

AU - Wallace, Gregory Q.

AU - Shand, Neil C.

AU - Mullen, Alexander B.

AU - Horan, Linda

AU - Graham, Duncan

AU - Faulds, Karen

AU - Boyd, Marie

PY - 2024/7

Y1 - 2024/7

N2 - Live chicken egg embryos offer new opportunities for evaluation and continuous monitoring of tumour growth for in vivo studies compared to traditional rodent models. Here, we report the first use of surface enhanced Raman scattering (SERS) mapping and surface enhanced spatially offset Raman scattering (SESORS) for the detection and localisation of targeted gold nanoparticles in live chicken egg embryos bearing a glioblastoma tumour.

AB - Live chicken egg embryos offer new opportunities for evaluation and continuous monitoring of tumour growth for in vivo studies compared to traditional rodent models. Here, we report the first use of surface enhanced Raman scattering (SERS) mapping and surface enhanced spatially offset Raman scattering (SESORS) for the detection and localisation of targeted gold nanoparticles in live chicken egg embryos bearing a glioblastoma tumour.

KW - tumour model

KW - Raman spectroscopy

KW - chicken egg embryos

KW - glioblastoma

UR - https://doi.org/10.15129/bd4589d4-3273-4baf-95ac-343693e19252

U2 - 10.1039/d4an00617h

DO - 10.1039/d4an00617h

M3 - Article

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VL - 149

SP - 3513

EP - 3517

JO - Analyst

JF - Analyst

IS - 13

ER -

Live chicken egg embryos as an alternative in vivo tumour model for deep surface enhanced Raman spectroscopy

Abstract

Funding

Keywords

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