Liquid-filled hard gelatin capsules: excipient/capsule compatibility studies

M. Kreiner, N. Thayne, D. Harkins, K. Rae, G. W. Halbert

Research output: Contribution to conferencePoster

Abstract

Encapsulation of pharmaceutical formulations as liquids or semisolids, within hard gelatin capsules, presents an important oral dosage strategy for poorly water-soluble drugs, resulting in good bioavailability and reproducible drug absorption. In addition, this technology offers an inherently safer process than powder filled capsules and tablets for highly potent or cytotoxic drugs by avoiding dust generation. Here we present a compatibility study of hard gelatin capsules with common excipients in absence of active pharmaceutical.

Conference

Conference7th APS International PharmSci Conference
CountryUnited Kingdom
CityGlasgow
Period5/09/167/09/16
Internet address

Fingerprint

Excipients
Gelatin
Capsules
Pharmaceutical Preparations
Drug Compounding
Dust
Powders
Biological Availability
Tablets
Technology
Water

Keywords

  • encapsulation
  • gelatin capsules
  • drug absorption

Cite this

Kreiner, M., Thayne, N., Harkins, D., Rae, K., & Halbert, G. W. (2016). Liquid-filled hard gelatin capsules: excipient/capsule compatibility studies. Poster session presented at 7th APS International PharmSci Conference, Glasgow, United Kingdom.
Kreiner, M. ; Thayne, N. ; Harkins, D. ; Rae, K. ; Halbert, G. W. / Liquid-filled hard gelatin capsules : excipient/capsule compatibility studies. Poster session presented at 7th APS International PharmSci Conference, Glasgow, United Kingdom.1 p.
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Kreiner, M, Thayne, N, Harkins, D, Rae, K & Halbert, GW 2016, 'Liquid-filled hard gelatin capsules: excipient/capsule compatibility studies' 7th APS International PharmSci Conference, Glasgow, United Kingdom, 5/09/16 - 7/09/16, .

Liquid-filled hard gelatin capsules : excipient/capsule compatibility studies. / Kreiner, M.; Thayne, N.; Harkins, D.; Rae, K.; Halbert, G. W.

2016. Poster session presented at 7th APS International PharmSci Conference, Glasgow, United Kingdom.

Research output: Contribution to conferencePoster

TY - CONF

T1 - Liquid-filled hard gelatin capsules

T2 - excipient/capsule compatibility studies

AU - Kreiner, M.

AU - Thayne, N.

AU - Harkins, D.

AU - Rae, K.

AU - Halbert, G. W.

PY - 2016/9/6

Y1 - 2016/9/6

N2 - Encapsulation of pharmaceutical formulations as liquids or semisolids, within hard gelatin capsules, presents an important oral dosage strategy for poorly water-soluble drugs, resulting in good bioavailability and reproducible drug absorption. In addition, this technology offers an inherently safer process than powder filled capsules and tablets for highly potent or cytotoxic drugs by avoiding dust generation. Here we present a compatibility study of hard gelatin capsules with common excipients in absence of active pharmaceutical.

AB - Encapsulation of pharmaceutical formulations as liquids or semisolids, within hard gelatin capsules, presents an important oral dosage strategy for poorly water-soluble drugs, resulting in good bioavailability and reproducible drug absorption. In addition, this technology offers an inherently safer process than powder filled capsules and tablets for highly potent or cytotoxic drugs by avoiding dust generation. Here we present a compatibility study of hard gelatin capsules with common excipients in absence of active pharmaceutical.

KW - encapsulation

KW - gelatin capsules

KW - drug absorption

UR - https://www.ukpharmsci.org/

M3 - Poster

ER -

Kreiner M, Thayne N, Harkins D, Rae K, Halbert GW. Liquid-filled hard gelatin capsules: excipient/capsule compatibility studies. 2016. Poster session presented at 7th APS International PharmSci Conference, Glasgow, United Kingdom.