Lipid-based nanoparticles for delivery of vaccine adjuvants and antigens: toward multicomponent vaccines

Despo Chatzikleanthous, Derek T O'Hagan, Roberto Adamo

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Abstract

Despite the many advances that have occurred in the field of vaccine adjuvants, there are still unmet needs that may enable the development of vaccines suitable for more challenging pathogens (e.g., HIV and tuberculosis) and for cancer vaccines. Liposomes have already been shown to be highly effective as adjuvant/delivery systems due to their versatility and likely will find further uses in this space. The broad potential of lipid-based delivery systems is highlighted by the recent approval of COVID-19 vaccines comprising lipid nanoparticles with encapsulated mRNA. This review provides an overview of the different approaches that can be evaluated for the design of lipid-based vaccine adjuvant/delivery systems for protein, carbohydrate, and nucleic acid-based antigens and how these strategies might be combined to develop multicomponent vaccines.
Original languageEnglish
Pages (from-to)2867-2888
Number of pages22
JournalMolecular Pharmaceutics
Volume18
Issue number8
Early online date15 Jul 2021
DOIs
Publication statusPublished - 2 Aug 2021

Keywords

  • COVID-19
  • adjuvants
  • delivery systems
  • lipid nanoparticles
  • vaccines

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