Abstract
Lipid-based nanoparticles provide a new mode of cancer treatment by delivering drugs to the target site in order to improve the drug pharmacokinetics and/or reduce their toxicities. Several of these nanoparticle-based anticancer therapeutics are currently being investigated in clinical trials, with some already approved for clinical practice. In this chapter, we will highlight the main features of these nanoparticles and describe their types and classes. We will examine some of the approved formulations and some of those currently investigated in clinical trials. In addition, we will discuss the major techniques that are involved in their manufacturing and characterization, along with the major challenges in translating basic research to the clinic. Moreover, we will discuss the use of lipid-based nanoparticles in the delivery of short interfering RNA. These nanoparticles promise innovative and better anticancer medications development for clinical cancer treatment.
| Original language | English |
|---|---|
| Title of host publication | Lipid Nanocarriers for Drug Targeting |
| Editors | Alexandru Mihai Grumezescu |
| Place of Publication | Amsterdam |
| Publisher | Elsevier |
| Chapter | 8 |
| Pages | 313-359 |
| Number of pages | 47 |
| ISBN (Print) | 9780128136881, 9780128136874 |
| DOIs | |
| Publication status | Published - 18 Apr 2018 |
Keywords
- cancer treatment
- drug delivery
- formulation method
- lipid-based nanoparticles
- liposomes
- micelles
- niosomes
- particles characterization