Lipid-based nanoparticles for cancer treatment

Research output: Chapter in Book/Report/Conference proceedingChapter

9 Citations (Scopus)

Abstract

Lipid-based nanoparticles provide a new mode of cancer treatment by delivering drugs to the target site in order to improve the drug pharmacokinetics and/or reduce their toxicities. Several of these nanoparticle-based anticancer therapeutics are currently being investigated in clinical trials, with some already approved for clinical practice. In this chapter, we will highlight the main features of these nanoparticles and describe their types and classes. We will examine some of the approved formulations and some of those currently investigated in clinical trials. In addition, we will discuss the major techniques that are involved in their manufacturing and characterization, along with the major challenges in translating basic research to the clinic. Moreover, we will discuss the use of lipid-based nanoparticles in the delivery of short interfering RNA. These nanoparticles promise innovative and better anticancer medications development for clinical cancer treatment.

Original languageEnglish
Title of host publicationLipid Nanocarriers for Drug Targeting
EditorsAlexandru Mihai Grumezescu
Place of PublicationAmsterdam
PublisherElsevier
Chapter8
Pages313-359
Number of pages47
ISBN (Print)9780128136881, 9780128136874
DOIs
Publication statusPublished - 18 Apr 2018

Keywords

  • cancer treatment
  • drug delivery
  • formulation method
  • lipid-based nanoparticles
  • liposomes
  • micelles
  • niosomes
  • particles characterization

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