Linking moisture induced variations in pharmaceutical primary powders to their tableting performance

R. Shinebaum, I. Gabbott, G. K. Reynolds, Hannah K. Batchelor, Andrew Ingram

Research output: Chapter in Book/Report/Conference proceedingConference contribution book


A drug is only a small proportion of a pharmaceutical tablet. Other excipients, for example binders and disintegrants, make up the bulk volume of the dosage form and therefore the properties they possess are important in determining the final quality and compaction attributes of a tablet. Pharmaceutical formulations are often wet granulated, for example via twin screw granulation (TSG), prior to compaction to ensure homogeneity and to improve their flowability. The tableting properties of pharmaceutical formulations can be characterised by their compressibility and compactibility. Compaction consists of compression and consolidation of a particulate-gas system due to an applied force and such mechanisms have become an important part of pharmaceutical development.
Original languageEnglish
Title of host publication2019 AIChE annual meeting proceedings
Place of Publication[S.I.]
ISBN (Electronic)9780816911127
Publication statusPublished - 14 Nov 2019
Event2019 AIChE Annual Meeting - Orlando, United States
Duration: 10 Nov 201915 Nov 2019

Publication series

NameAIChE Annual Meeting, Conference Proceedings


Conference2019 AIChE Annual Meeting
Country/TerritoryUnited States


  • pharmaceutical powders
  • twin screw granulation
  • microcrystalline cellulose


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