Ligand-induced reactivity of β-diketiminate magnesium complexes for regioselective functionalization of fluoroarenes via C-H or C-F bond activations

Laia Davin Cardona, Ross McLellan, Alan R. Kennedy, Eva Hevia

Research output: Contribution to journalArticle

21 Citations (Scopus)
26 Downloads (Pure)

Abstract

Using β-diketiminate Mg(II) complexes containing either alkyl, aryl or amide groups, the regioselective functionalization of a wide range of fluoroarenes is accomplished but in uniquely different ways. Overcoming common limitations of traditional s-block bases, kinetically activated [(DippNacnac)Mg(TMP)] (1) deprotonates these molecules at room temperature, trapping sensitive fluoroaryl anions that can then engage in Negishi cross-coupling; whereas [(DippNacnac)Mg(R)THF] (R = nBu, Ph, benzofuryl) have proved to be effective reagents for C–F bond alkylation/arylation via pyridine directed C–F bond cleavage.
Original languageEnglish
Pages (from-to)11650-11653
Number of pages4
JournalChemical Communications
Issue number85
Early online date29 Sep 2017
DOIs
Publication statusPublished - 4 Nov 2017

Keywords

  • fluoroarene
  • ligand-ligand cooperation
  • metallation

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