Lifetime exposure to ambient ultraviolet radiation and the risk for cataract extraction and age-related macular degeneration: the Alienor Study

Cécile Delcourt, Audrey Cougnard-Grégoire, Mathieu Boniol, Isabelle Carrière, Jean-François Doré, Marie-Noëlle Delyfer, Marie-Bénédicte Rougier, Mélanie Le Goff, Jean-François Dartigues, Pascale Barberger-Gateau, Jean-François Korobelnik

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Abstract

While exposure to ultraviolet radiation (UVR) is a recognized risk factor for cataract, its association is more controversial with age-related macular degeneration (AMD). We report the associations of lifetime exposure to ambient UVR with cataract extraction and AMD. The Alienor Study is a population-based study of 963 residents of Bordeaux (France), aged 73 years or more. Lifetime exposure to ambient UVR was estimated from residential history and Eurosun satellite-based estimations of ground UVR. It was divided in three groups (lower quartile, intermediate quartiles, upper quartile), using the intermediate quartiles as the reference. Early and late AMD was classified from retinal color photographs. Cataract extraction was defined as absence of the natural lens at slit-lamp. After multivariate adjustment, subjects in the upper quartile of lifetime ambient UVR exposure were at increased risk for cataract extraction (odds ratio [OR] = 1.53; 95% confidence interval [CI], 1.04-2.26; P = 0.03) and for early AMD (OR = 1.59; 95% CI, 1.04-2.44; P = 0.03), by comparison with subjects in the intermediate quartiles. Subjects in the lower quartile of UVR exposure also were at increased risk for early AMD (OR = 1.69; 95% CI, 1.06-2.69; P = 0.03), by comparison with those with medium exposure. Associations of late AMD with UVR exposure was not statistically significant. This study further confirms the increased risk for cataract extraction in subjects exposed to high ambient UVR. Moreover, it suggests that risk for early AMD is increased in subjects exposed to high UVR, but also to low UVR, by comparison with medium exposures.
LanguageEnglish
Pages7619-7627
Number of pages9
JournalInvestigative Ophthalmology and Visual Science
Volume55
Issue number11
DOIs
Publication statusPublished - 1 Nov 2014

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Cataract Extraction
Macular Degeneration
Radiation
Odds Ratio
Confidence Intervals
Cataract
Lenses
France
Color
History
Population
Radiation Exposure

Keywords

  • aged
  • cataract
  • cataract extraction
  • confidence intervals
  • environmental exposure
  • female
  • follow-up studies
  • France
  • humans
  • incidence
  • crystalline lens
  • macular degeneration
  • male
  • prognosis
  • retina
  • retrospective studies
  • risk assessment
  • risk factors
  • time factors
  • ultraviolet rays

Cite this

Delcourt, Cécile ; Cougnard-Grégoire, Audrey ; Boniol, Mathieu ; Carrière, Isabelle ; Doré, Jean-François ; Delyfer, Marie-Noëlle ; Rougier, Marie-Bénédicte ; Le Goff, Mélanie ; Dartigues, Jean-François ; Barberger-Gateau, Pascale ; Korobelnik, Jean-François. / Lifetime exposure to ambient ultraviolet radiation and the risk for cataract extraction and age-related macular degeneration : the Alienor Study. In: Investigative Ophthalmology and Visual Science. 2014 ; Vol. 55, No. 11. pp. 7619-7627.
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abstract = "While exposure to ultraviolet radiation (UVR) is a recognized risk factor for cataract, its association is more controversial with age-related macular degeneration (AMD). We report the associations of lifetime exposure to ambient UVR with cataract extraction and AMD. The Alienor Study is a population-based study of 963 residents of Bordeaux (France), aged 73 years or more. Lifetime exposure to ambient UVR was estimated from residential history and Eurosun satellite-based estimations of ground UVR. It was divided in three groups (lower quartile, intermediate quartiles, upper quartile), using the intermediate quartiles as the reference. Early and late AMD was classified from retinal color photographs. Cataract extraction was defined as absence of the natural lens at slit-lamp. After multivariate adjustment, subjects in the upper quartile of lifetime ambient UVR exposure were at increased risk for cataract extraction (odds ratio [OR] = 1.53; 95{\%} confidence interval [CI], 1.04-2.26; P = 0.03) and for early AMD (OR = 1.59; 95{\%} CI, 1.04-2.44; P = 0.03), by comparison with subjects in the intermediate quartiles. Subjects in the lower quartile of UVR exposure also were at increased risk for early AMD (OR = 1.69; 95{\%} CI, 1.06-2.69; P = 0.03), by comparison with those with medium exposure. Associations of late AMD with UVR exposure was not statistically significant. This study further confirms the increased risk for cataract extraction in subjects exposed to high ambient UVR. Moreover, it suggests that risk for early AMD is increased in subjects exposed to high UVR, but also to low UVR, by comparison with medium exposures.",
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Delcourt, C, Cougnard-Grégoire, A, Boniol, M, Carrière, I, Doré, J-F, Delyfer, M-N, Rougier, M-B, Le Goff, M, Dartigues, J-F, Barberger-Gateau, P & Korobelnik, J-F 2014, 'Lifetime exposure to ambient ultraviolet radiation and the risk for cataract extraction and age-related macular degeneration: the Alienor Study' Investigative Ophthalmology and Visual Science, vol. 55, no. 11, pp. 7619-7627. https://doi.org/10.1167/iovs.14-14471

Lifetime exposure to ambient ultraviolet radiation and the risk for cataract extraction and age-related macular degeneration : the Alienor Study. / Delcourt, Cécile; Cougnard-Grégoire, Audrey; Boniol, Mathieu; Carrière, Isabelle; Doré, Jean-François; Delyfer, Marie-Noëlle; Rougier, Marie-Bénédicte; Le Goff, Mélanie; Dartigues, Jean-François; Barberger-Gateau, Pascale; Korobelnik, Jean-François.

In: Investigative Ophthalmology and Visual Science, Vol. 55, No. 11, 01.11.2014, p. 7619-7627.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Lifetime exposure to ambient ultraviolet radiation and the risk for cataract extraction and age-related macular degeneration

T2 - Investigative Ophthalmology and Visual Science

AU - Delcourt, Cécile

AU - Cougnard-Grégoire, Audrey

AU - Boniol, Mathieu

AU - Carrière, Isabelle

AU - Doré, Jean-François

AU - Delyfer, Marie-Noëlle

AU - Rougier, Marie-Bénédicte

AU - Le Goff, Mélanie

AU - Dartigues, Jean-François

AU - Barberger-Gateau, Pascale

AU - Korobelnik, Jean-François

N1 - Copyright 2014 The Association for Research in Vision and Ophthalmology, Inc.

PY - 2014/11/1

Y1 - 2014/11/1

N2 - While exposure to ultraviolet radiation (UVR) is a recognized risk factor for cataract, its association is more controversial with age-related macular degeneration (AMD). We report the associations of lifetime exposure to ambient UVR with cataract extraction and AMD. The Alienor Study is a population-based study of 963 residents of Bordeaux (France), aged 73 years or more. Lifetime exposure to ambient UVR was estimated from residential history and Eurosun satellite-based estimations of ground UVR. It was divided in three groups (lower quartile, intermediate quartiles, upper quartile), using the intermediate quartiles as the reference. Early and late AMD was classified from retinal color photographs. Cataract extraction was defined as absence of the natural lens at slit-lamp. After multivariate adjustment, subjects in the upper quartile of lifetime ambient UVR exposure were at increased risk for cataract extraction (odds ratio [OR] = 1.53; 95% confidence interval [CI], 1.04-2.26; P = 0.03) and for early AMD (OR = 1.59; 95% CI, 1.04-2.44; P = 0.03), by comparison with subjects in the intermediate quartiles. Subjects in the lower quartile of UVR exposure also were at increased risk for early AMD (OR = 1.69; 95% CI, 1.06-2.69; P = 0.03), by comparison with those with medium exposure. Associations of late AMD with UVR exposure was not statistically significant. This study further confirms the increased risk for cataract extraction in subjects exposed to high ambient UVR. Moreover, it suggests that risk for early AMD is increased in subjects exposed to high UVR, but also to low UVR, by comparison with medium exposures.

AB - While exposure to ultraviolet radiation (UVR) is a recognized risk factor for cataract, its association is more controversial with age-related macular degeneration (AMD). We report the associations of lifetime exposure to ambient UVR with cataract extraction and AMD. The Alienor Study is a population-based study of 963 residents of Bordeaux (France), aged 73 years or more. Lifetime exposure to ambient UVR was estimated from residential history and Eurosun satellite-based estimations of ground UVR. It was divided in three groups (lower quartile, intermediate quartiles, upper quartile), using the intermediate quartiles as the reference. Early and late AMD was classified from retinal color photographs. Cataract extraction was defined as absence of the natural lens at slit-lamp. After multivariate adjustment, subjects in the upper quartile of lifetime ambient UVR exposure were at increased risk for cataract extraction (odds ratio [OR] = 1.53; 95% confidence interval [CI], 1.04-2.26; P = 0.03) and for early AMD (OR = 1.59; 95% CI, 1.04-2.44; P = 0.03), by comparison with subjects in the intermediate quartiles. Subjects in the lower quartile of UVR exposure also were at increased risk for early AMD (OR = 1.69; 95% CI, 1.06-2.69; P = 0.03), by comparison with those with medium exposure. Associations of late AMD with UVR exposure was not statistically significant. This study further confirms the increased risk for cataract extraction in subjects exposed to high ambient UVR. Moreover, it suggests that risk for early AMD is increased in subjects exposed to high UVR, but also to low UVR, by comparison with medium exposures.

KW - aged

KW - cataract

KW - cataract extraction

KW - confidence intervals

KW - environmental exposure

KW - female

KW - follow-up studies

KW - France

KW - humans

KW - incidence

KW - crystalline lens

KW - macular degeneration

KW - male

KW - prognosis

KW - retina

KW - retrospective studies

KW - risk assessment

KW - risk factors

KW - time factors

KW - ultraviolet rays

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U2 - 10.1167/iovs.14-14471

DO - 10.1167/iovs.14-14471

M3 - Article

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SP - 7619

EP - 7627

JO - Investigative Ophthalmology and Visual Science

JF - Investigative Ophthalmology and Visual Science

SN - 0146-0404

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ER -