Lessons to be learnt from Leishmania studies

CD Shaw, KC Carter

Research output: Contribution to journalArticle

8 Citations (Scopus)
85 Downloads (Pure)

Abstract

Leishmaniasis is a disease caused by infection with the protozoan parasite Leishmania, which is responsible for three main types of disease: cutaneous leishmaniasis, visceral leishmaniasis and mucocutaneous leishmaniasis based to the site of infection for the particular species. This presents a major challenge to successful drug treatment, as a drug must not only reach antileishmanial concentrations in infected macrophages, the parasites' host cell, but also reach infected cells in locations specific to the type of disease. In this paper we discuss how studies using Leishmania have contributed to our knowledge on how drug delivery systems can be used to improve drug efficacy and delivery.

Original languageEnglish
Pages (from-to)1531-1544
Number of pages14
JournalNanomedicine
Volume9
Issue number10
DOIs
Publication statusPublished - 1 Jul 2014

Keywords

  • Leishmania studies
  • drug delivery
  • drug efficacy

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