Abstract
Mitogen-activated protein kinases are well-known mediators of signal transduction of higher eukaryotes regulating important processes like proliferation, differentiation, stress response and apoptosis. In Leishmania, the typical three-tiered module of MAP kinase signal transduction pathways is present. However, typical activators like cell surface receptors and substrates such as RNA polymerase II transcription factors are missing. Here, I describe the set of 15 putative mitogen-activated protein kinases encoded in the Leishmania genome and discuss their potential function.
| Original language | English |
|---|---|
| Pages (from-to) | 1053-62 |
| Number of pages | 10 |
| Journal | International Journal for Parasitology |
| Volume | 37 |
| Issue number | 10 |
| Early online date | 29 Apr 2007 |
| DOIs | |
| Publication status | Published - Aug 2007 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- amino acid sequence
- animals
- gene expression regulation
- leishmania
- mitogen-activated protein kinases
- molecular sequence data
- phylogeny
- protozoan proteins
- signal transduction
- deletion analysis
- kinetoplastida
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