Leishmania MAP kinases-familiar proteins in an unusual context

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

Mitogen-activated protein kinases are well-known mediators of signal transduction of higher eukaryotes regulating important processes like proliferation, differentiation, stress response and apoptosis. In Leishmania, the typical three-tiered module of MAP kinase signal transduction pathways is present. However, typical activators like cell surface receptors and substrates such as RNA polymerase II transcription factors are missing. Here, I describe the set of 15 putative mitogen-activated protein kinases encoded in the Leishmania genome and discuss their potential function.

LanguageEnglish
Pages1053-62
Number of pages10
JournalInternational Journal for Parasitology
Volume37
Issue number10
Early online date29 Apr 2007
DOIs
Publication statusPublished - Aug 2007

Fingerprint

Leishmania
Mitogen-Activated Protein Kinases
Protein Kinases
Signal Transduction
MAP Kinase Signaling System
RNA Polymerase II
Cell Surface Receptors
Eukaryota
Transcription Factors
Genome
Apoptosis

Keywords

  • amino acid sequence
  • animals
  • gene expression regulation
  • leishmania
  • mitogen-activated protein kinases
  • molecular sequence data
  • phylogeny
  • protozoan proteins
  • signal transduction
  • deletion analysis
  • kinetoplastida

Cite this

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abstract = "Mitogen-activated protein kinases are well-known mediators of signal transduction of higher eukaryotes regulating important processes like proliferation, differentiation, stress response and apoptosis. In Leishmania, the typical three-tiered module of MAP kinase signal transduction pathways is present. However, typical activators like cell surface receptors and substrates such as RNA polymerase II transcription factors are missing. Here, I describe the set of 15 putative mitogen-activated protein kinases encoded in the Leishmania genome and discuss their potential function.",
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Leishmania MAP kinases-familiar proteins in an unusual context. / Wiese, Martin.

In: International Journal for Parasitology, Vol. 37, No. 10, 08.2007, p. 1053-62.

Research output: Contribution to journalArticle

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