Abstract
Mitogen-activated protein kinases are well-known mediators of signal transduction of higher eukaryotes regulating important processes like proliferation, differentiation, stress response and apoptosis. In Leishmania, the typical three-tiered module of MAP kinase signal transduction pathways is present. However, typical activators like cell surface receptors and substrates such as RNA polymerase II transcription factors are missing. Here, I describe the set of 15 putative mitogen-activated protein kinases encoded in the Leishmania genome and discuss their potential function.
| Language | English |
|---|---|
| Pages | 1053-62 |
| Number of pages | 10 |
| Journal | International Journal for Parasitology |
| Volume | 37 |
| Issue number | 10 |
| Early online date | 29 Apr 2007 |
| DOIs | |
| Publication status | Published - Aug 2007 |
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Keywords
- amino acid sequence
- animals
- gene expression regulation
- leishmania
- mitogen-activated protein kinases
- molecular sequence data
- phylogeny
- protozoan proteins
- signal transduction
- deletion analysis
- kinetoplastida
Cite this
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Leishmania MAP kinases-familiar proteins in an unusual context. / Wiese, Martin.
In: International Journal for Parasitology, Vol. 37, No. 10, 08.2007, p. 1053-62.Research output: Contribution to journal › Article
TY - JOUR
T1 - Leishmania MAP kinases-familiar proteins in an unusual context
AU - Wiese, Martin
PY - 2007/8
Y1 - 2007/8
N2 - Mitogen-activated protein kinases are well-known mediators of signal transduction of higher eukaryotes regulating important processes like proliferation, differentiation, stress response and apoptosis. In Leishmania, the typical three-tiered module of MAP kinase signal transduction pathways is present. However, typical activators like cell surface receptors and substrates such as RNA polymerase II transcription factors are missing. Here, I describe the set of 15 putative mitogen-activated protein kinases encoded in the Leishmania genome and discuss their potential function.
AB - Mitogen-activated protein kinases are well-known mediators of signal transduction of higher eukaryotes regulating important processes like proliferation, differentiation, stress response and apoptosis. In Leishmania, the typical three-tiered module of MAP kinase signal transduction pathways is present. However, typical activators like cell surface receptors and substrates such as RNA polymerase II transcription factors are missing. Here, I describe the set of 15 putative mitogen-activated protein kinases encoded in the Leishmania genome and discuss their potential function.
KW - amino acid sequence
KW - animals
KW - gene expression regulation
KW - leishmania
KW - mitogen-activated protein kinases
KW - molecular sequence data
KW - phylogeny
KW - protozoan proteins
KW - signal transduction
KW - deletion analysis
KW - kinetoplastida
UR - http://www.sciencedirect.com/science/journal/00207519
U2 - 10.1016/j.ijpara.2007.04.008
DO - 10.1016/j.ijpara.2007.04.008
M3 - Article
VL - 37
SP - 1053
EP - 1062
JO - International Journal for Parasitology
T2 - International Journal for Parasitology
JF - International Journal for Parasitology
SN - 0020-7519
IS - 10
ER -