Leishmania MAP kinases-familiar proteins in an unusual context

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Abstract

Mitogen-activated protein kinases are well-known mediators of signal transduction of higher eukaryotes regulating important processes like proliferation, differentiation, stress response and apoptosis. In Leishmania, the typical three-tiered module of MAP kinase signal transduction pathways is present. However, typical activators like cell surface receptors and substrates such as RNA polymerase II transcription factors are missing. Here, I describe the set of 15 putative mitogen-activated protein kinases encoded in the Leishmania genome and discuss their potential function.

Original languageEnglish
Pages (from-to)1053-62
Number of pages10
JournalInternational Journal for Parasitology
Volume37
Issue number10
Early online date29 Apr 2007
DOIs
Publication statusPublished - Aug 2007

Keywords

  • amino acid sequence
  • animals
  • gene expression regulation
  • leishmania
  • mitogen-activated protein kinases
  • molecular sequence data
  • phylogeny
  • protozoan proteins
  • signal transduction
  • deletion analysis
  • kinetoplastida

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