Learning from data to predict future symptoms of oncology patients

Nikolaos Papachristou, Daniel Puschmann, Payam Barnaghi, Bruce Cooper, Xiao Hu, Roma Maguire, Kathi Apostolidis, Yvette P. Conley, Marilyn Hammer, Stylianos Katsaragakis, Kord M. Kober, Jon D. Levine, Lisa McCann, Elisabeth Patiraki, Eileen P. Furlong, Patricia A. Fox, Steven M. Paul, Emma Ream, Fay Wright, Christine Miaskowski

Research output: Contribution to journalArticle

3 Citations (Scopus)
20 Downloads (Pure)

Abstract

Effective symptom management is a critical component of cancer treatment. Computational tools that predict the course and severity of these symptoms have the potential to assist oncology clinicians to personalize the patient's treatment regimen more efficiently and provide more aggressive and timely interventions. Three common and inter-related symptoms in cancer patients are depression, anxiety, and sleep disturbance. In this paper, we elaborate on the efficiency of Support Vector Regression (SVR) and Non-linear Canonical Correlation Analysis by Neural Networks (n-CCA) to predict the severity of the aforementioned symptoms between two different time points during a cycle of chemotherapy (CTX). Our results demonstrate that these two methods produced equivalent results for all three symptoms. These types of predictive models can be used to identify high risk patients, educate patients about their symptom experience, and improve the timing of pre-emptive and personalized symptom management interventions.
Original languageEnglish
Article numbere0208808
Number of pages17
JournalPLoS ONE
Volume13
Issue number12
DOIs
Publication statusPublished - 31 Dec 2018

Keywords

  • symptom management
  • cancer treatment research
  • oncology patients
  • chemotherapy

Fingerprint Dive into the research topics of 'Learning from data to predict future symptoms of oncology patients'. Together they form a unique fingerprint.

  • Cite this

    Papachristou, N., Puschmann, D., Barnaghi, P., Cooper, B., Hu, X., Maguire, R., Apostolidis, K., Conley, Y. P., Hammer, M., Katsaragakis, S., Kober, K. M., Levine, J. D., McCann, L., Patiraki, E., Furlong, E. P., Fox, P. A., Paul, S. M., Ream, E., Wright, F., & Miaskowski, C. (2018). Learning from data to predict future symptoms of oncology patients. PLoS ONE, 13(12), [e0208808]. https://doi.org/10.1371/journal.pone.0208808