Laser-wakefield accelerators for medical phase contrast imaging: Monte Carlo simulations and experimental studies

S. Cipiccia, D. Reboredo, F. A. Vittoria, G. H. Welsh, P. Grant, D. W. Grant, E. Brunetti, S. M. Wiggins, A. Olivo, D. A. Jaroszynski

Research output: Chapter in Book/Report/Conference proceedingConference contribution book

Abstract

X-ray phase contrast imaging (X-PCi) is a very promising method of dramatically enhancing the contrast of X-ray images of microscopic weakly absorbing objects and soft tissue, which may lead to significant advancement in medical imaging with high-resolution and low-dose. The interest in X-PCi is giving rise to a demand for effective simulation methods. Monte Carlo codes have been proved a valuable tool for studying X-PCi including coherent effects. The laser-plasma wakefield accelerators (LWFA) is a very compact particle accelerator that uses plasma as an accelerating medium. Accelerating gradient in excess of 1 GV/cm can be obtained, which makes them over a thousand times more compact than conventional accelerators. LWFA are also sources of brilliant betatron radiation, which are promising for applications including medical imaging. We present a study that explores the potential of LWFA-based betatron sources for medical X-PCi and investigate its resolution limit using numerical simulations based on the FLUKA Monte Carlo code, and present preliminary experimental results
LanguageEnglish
Title of host publicationProceedings of SPIE
Subtitle of host publicationLaser Acceleration of Electrons, Protons, and Ions III; and Medical Applications of Laser-Generated Beams of Particles III
EditorsKenneth W. D. Ledingham, Eric Esarey, Klaus Spohr, Carl B. Schroeder, Paul McKenna, Florian J. Grüner, Paul R. Bolton
Number of pages5
Volume9514
DOIs
Publication statusPublished - 13 Apr 2015

Fingerprint

phase contrast
accelerators
plasma accelerators
laser plasmas
betatrons
lasers
x rays
simulation
particle accelerators
dosage
gradients
high resolution
radiation

Keywords

  • lasers
  • phase contrast
  • simulations
  • plasmas
  • medical imaging
  • X-raya
  • numerical simulation
  • partical accelerators
  • radiation
  • tissues

Cite this

Cipiccia, S., Reboredo, D., Vittoria, F. A., Welsh, G. H., Grant, P., Grant, D. W., ... Jaroszynski, D. A. (2015). Laser-wakefield accelerators for medical phase contrast imaging: Monte Carlo simulations and experimental studies. In K. W. D. Ledingham, E. Esarey, K. Spohr, C. B. Schroeder, P. McKenna, F. J. Grüner, & P. R. Bolton (Eds.), Proceedings of SPIE: Laser Acceleration of Electrons, Protons, and Ions III; and Medical Applications of Laser-Generated Beams of Particles III (Vol. 9514). [951417] https://doi.org/10.1117/12.2178837
Cipiccia, S. ; Reboredo, D. ; Vittoria, F. A. ; Welsh, G. H. ; Grant, P. ; Grant, D. W. ; Brunetti, E. ; Wiggins, S. M. ; Olivo, A. ; Jaroszynski, D. A. / Laser-wakefield accelerators for medical phase contrast imaging : Monte Carlo simulations and experimental studies. Proceedings of SPIE: Laser Acceleration of Electrons, Protons, and Ions III; and Medical Applications of Laser-Generated Beams of Particles III. editor / Kenneth W. D. Ledingham ; Eric Esarey ; Klaus Spohr ; Carl B. Schroeder ; Paul McKenna ; Florian J. Grüner ; Paul R. Bolton. Vol. 9514 2015.
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abstract = "X-ray phase contrast imaging (X-PCi) is a very promising method of dramatically enhancing the contrast of X-ray images of microscopic weakly absorbing objects and soft tissue, which may lead to significant advancement in medical imaging with high-resolution and low-dose. The interest in X-PCi is giving rise to a demand for effective simulation methods. Monte Carlo codes have been proved a valuable tool for studying X-PCi including coherent effects. The laser-plasma wakefield accelerators (LWFA) is a very compact particle accelerator that uses plasma as an accelerating medium. Accelerating gradient in excess of 1 GV/cm can be obtained, which makes them over a thousand times more compact than conventional accelerators. LWFA are also sources of brilliant betatron radiation, which are promising for applications including medical imaging. We present a study that explores the potential of LWFA-based betatron sources for medical X-PCi and investigate its resolution limit using numerical simulations based on the FLUKA Monte Carlo code, and present preliminary experimental results",
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note = "Copyright 2015 Society of Photo-Optical Instrumentation Engineers. One print or electronic copy may be made for personal use only. Systematic reproduction and distribution, duplication of any materi al in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited.",
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Cipiccia, S, Reboredo, D, Vittoria, FA, Welsh, GH, Grant, P, Grant, DW, Brunetti, E, Wiggins, SM, Olivo, A & Jaroszynski, DA 2015, Laser-wakefield accelerators for medical phase contrast imaging: Monte Carlo simulations and experimental studies. in KWD Ledingham, E Esarey, K Spohr, CB Schroeder, P McKenna, FJ Grüner & PR Bolton (eds), Proceedings of SPIE: Laser Acceleration of Electrons, Protons, and Ions III; and Medical Applications of Laser-Generated Beams of Particles III. vol. 9514, 951417. https://doi.org/10.1117/12.2178837

Laser-wakefield accelerators for medical phase contrast imaging : Monte Carlo simulations and experimental studies. / Cipiccia, S.; Reboredo, D.; Vittoria, F. A.; Welsh, G. H.; Grant, P.; Grant, D. W.; Brunetti, E.; Wiggins, S. M.; Olivo, A.; Jaroszynski, D. A.

Proceedings of SPIE: Laser Acceleration of Electrons, Protons, and Ions III; and Medical Applications of Laser-Generated Beams of Particles III. ed. / Kenneth W. D. Ledingham; Eric Esarey; Klaus Spohr; Carl B. Schroeder; Paul McKenna; Florian J. Grüner; Paul R. Bolton. Vol. 9514 2015. 951417.

Research output: Chapter in Book/Report/Conference proceedingConference contribution book

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AU - Cipiccia, S.

AU - Reboredo, D.

AU - Vittoria, F. A.

AU - Welsh, G. H.

AU - Grant, P.

AU - Grant, D. W.

AU - Brunetti, E.

AU - Wiggins, S. M.

AU - Olivo, A.

AU - Jaroszynski, D. A.

N1 - Copyright 2015 Society of Photo-Optical Instrumentation Engineers. One print or electronic copy may be made for personal use only. Systematic reproduction and distribution, duplication of any materi al in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited.

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N2 - X-ray phase contrast imaging (X-PCi) is a very promising method of dramatically enhancing the contrast of X-ray images of microscopic weakly absorbing objects and soft tissue, which may lead to significant advancement in medical imaging with high-resolution and low-dose. The interest in X-PCi is giving rise to a demand for effective simulation methods. Monte Carlo codes have been proved a valuable tool for studying X-PCi including coherent effects. The laser-plasma wakefield accelerators (LWFA) is a very compact particle accelerator that uses plasma as an accelerating medium. Accelerating gradient in excess of 1 GV/cm can be obtained, which makes them over a thousand times more compact than conventional accelerators. LWFA are also sources of brilliant betatron radiation, which are promising for applications including medical imaging. We present a study that explores the potential of LWFA-based betatron sources for medical X-PCi and investigate its resolution limit using numerical simulations based on the FLUKA Monte Carlo code, and present preliminary experimental results

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KW - lasers

KW - phase contrast

KW - simulations

KW - plasmas

KW - medical imaging

KW - X-raya

KW - numerical simulation

KW - partical accelerators

KW - radiation

KW - tissues

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DO - 10.1117/12.2178837

M3 - Conference contribution book

SN - 9781628416350

VL - 9514

BT - Proceedings of SPIE

A2 - Ledingham, Kenneth W. D.

A2 - Esarey, Eric

A2 - Spohr, Klaus

A2 - Schroeder, Carl B.

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A2 - Bolton, Paul R.

ER -

Cipiccia S, Reboredo D, Vittoria FA, Welsh GH, Grant P, Grant DW et al. Laser-wakefield accelerators for medical phase contrast imaging: Monte Carlo simulations and experimental studies. In Ledingham KWD, Esarey E, Spohr K, Schroeder CB, McKenna P, Grüner FJ, Bolton PR, editors, Proceedings of SPIE: Laser Acceleration of Electrons, Protons, and Ions III; and Medical Applications of Laser-Generated Beams of Particles III. Vol. 9514. 2015. 951417 https://doi.org/10.1117/12.2178837