Laser-wakefield accelerators for medical phase contrast imaging: Monte Carlo simulations and experimental studies

S. Cipiccia; D. Reboredo; F. A. Vittoria; G. H. Welsh; P. Grant; D. W. Grant; E. Brunetti; S. M. Wiggins; A. Olivo; D. A. Jaroszynski

doi:10.1117/12.2178837

Laser-wakefield accelerators for medical phase contrast imaging: Monte Carlo simulations and experimental studies

S. Cipiccia, D. Reboredo, F. A. Vittoria, G. H. Welsh, P. Grant, D. W. Grant, E. Brunetti, S. M. Wiggins, A. Olivo, D. A. Jaroszynski

Physics

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution book

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Abstract

X-ray phase contrast imaging (X-PCi) is a very promising method of dramatically enhancing the contrast of X-ray images of microscopic weakly absorbing objects and soft tissue, which may lead to significant advancement in medical imaging with high-resolution and low-dose. The interest in X-PCi is giving rise to a demand for effective simulation methods. Monte Carlo codes have been proved a valuable tool for studying X-PCi including coherent effects. The laser-plasma wakefield accelerators (LWFA) is a very compact particle accelerator that uses plasma as an accelerating medium. Accelerating gradient in excess of 1 GV/cm can be obtained, which makes them over a thousand times more compact than conventional accelerators. LWFA are also sources of brilliant betatron radiation, which are promising for applications including medical imaging. We present a study that explores the potential of LWFA-based betatron sources for medical X-PCi and investigate its resolution limit using numerical simulations based on the FLUKA Monte Carlo code, and present preliminary experimental results

Original language	English
Title of host publication	Proceedings of SPIE
Subtitle of host publication	Laser Acceleration of Electrons, Protons, and Ions III; and Medical Applications of Laser-Generated Beams of Particles III
Editors	Kenneth W. D. Ledingham, Eric Esarey, Klaus Spohr, Carl B. Schroeder, Paul McKenna, Florian J. Grüner, Paul R. Bolton
Number of pages	5
Volume	9514
DOIs	https://doi.org/10.1117/12.2178837
Publication status	Published - 13 Apr 2015

Keywords

lasers
phase contrast
simulations
plasmas
medical imaging
X-raya
numerical simulation
partical accelerators
radiation
tissues

Access to Document

10.1117/12.2178837

Cipiccia-etal-SPIE-2015-Laser-wakefield-accelerators-for-medical-phase-contrast-imagingAccepted author manuscript, 622 KB

University Of Strathclyde - Equipment Account
Gachagan, A. (Principal Investigator), He, W. (Principal Investigator), Jaroszynski, D. (Principal Investigator), Martin, R. (Principal Investigator), McArthur, S. (Principal Investigator), McArthur, S. (Principal Investigator), Connolly, P. (Co-investigator), Edwards, P. (Co-investigator), Faulds, K. (Co-investigator), Florence, A. (Co-investigator), Graham, D. (Co-investigator), Leithead, B. (Co-investigator), Sefcik, J. (Co-investigator), Ter Horst, J. (Co-investigator), Trager-Cowan, C. (Co-investigator), Uttamchandani, D. (Co-investigator) & Wark, A. (Co-investigator)
EPSRC (Engineering and Physical Sciences Research Council)
1/08/13 → 28/02/23
Project: Research
EUCARD2
Jaroszynski, D. (Principal Investigator)
European Commission - FP7 - Cooperation only
1/05/13 → 30/04/17
Project: Research
LASERLAB-EUROPE
Jaroszynski, D. (Principal Investigator)
European Commission - FP7 - Cooperation only
1/06/12 → 30/11/15
Project: Research

ARCHIE-WeSt (UOSHPC)
Martin, R. (Manager)
University Of Strathclyde
Facility/equipment: Facility

Cite this

Cipiccia, S., Reboredo, D., Vittoria, F. A., Welsh, G. H., Grant, P., Grant, D. W., Brunetti, E., Wiggins, S. M., Olivo, A., & Jaroszynski, D. A. (2015). Laser-wakefield accelerators for medical phase contrast imaging: Monte Carlo simulations and experimental studies. In K. W. D. Ledingham, E. Esarey, K. Spohr, C. B. Schroeder, P. McKenna, F. J. Grüner, & P. R. Bolton (Eds.), Proceedings of SPIE: Laser Acceleration of Electrons, Protons, and Ions III; and Medical Applications of Laser-Generated Beams of Particles III (Vol. 9514). Article 951417 https://doi.org/10.1117/12.2178837

Cipiccia, S. ; Reboredo, D. ; Vittoria, F. A. et al. / Laser-wakefield accelerators for medical phase contrast imaging : Monte Carlo simulations and experimental studies. Proceedings of SPIE: Laser Acceleration of Electrons, Protons, and Ions III; and Medical Applications of Laser-Generated Beams of Particles III. editor / Kenneth W. D. Ledingham ; Eric Esarey ; Klaus Spohr ; Carl B. Schroeder ; Paul McKenna ; Florian J. Grüner ; Paul R. Bolton. Vol. 9514 2015.

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abstract = "X-ray phase contrast imaging (X-PCi) is a very promising method of dramatically enhancing the contrast of X-ray images of microscopic weakly absorbing objects and soft tissue, which may lead to significant advancement in medical imaging with high-resolution and low-dose. The interest in X-PCi is giving rise to a demand for effective simulation methods. Monte Carlo codes have been proved a valuable tool for studying X-PCi including coherent effects. The laser-plasma wakefield accelerators (LWFA) is a very compact particle accelerator that uses plasma as an accelerating medium. Accelerating gradient in excess of 1 GV/cm can be obtained, which makes them over a thousand times more compact than conventional accelerators. LWFA are also sources of brilliant betatron radiation, which are promising for applications including medical imaging. We present a study that explores the potential of LWFA-based betatron sources for medical X-PCi and investigate its resolution limit using numerical simulations based on the FLUKA Monte Carlo code, and present preliminary experimental results",

keywords = "lasers, phase contrast, simulations, plasmas, medical imaging, X-raya, numerical simulation, partical accelerators, radiation, tissues",

author = "S. Cipiccia and D. Reboredo and Vittoria, {F. A.} and Welsh, {G. H.} and P. Grant and Grant, {D. W.} and E. Brunetti and Wiggins, {S. M.} and A. Olivo and Jaroszynski, {D. A.}",

note = "Copyright 2015 Society of Photo-Optical Instrumentation Engineers. One print or electronic copy may be made for personal use only. Systematic reproduction and distribution, duplication of any materi al in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited. ",

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language = "English",

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Cipiccia, S, Reboredo, D, Vittoria, FA, Welsh, GH, Grant, P, Grant, DW, Brunetti, E , Wiggins, SM, Olivo, A & Jaroszynski, DA 2015, Laser-wakefield accelerators for medical phase contrast imaging: Monte Carlo simulations and experimental studies. in KWD Ledingham, E Esarey, K Spohr, CB Schroeder, P McKenna, FJ Grüner & PR Bolton (eds), Proceedings of SPIE: Laser Acceleration of Electrons, Protons, and Ions III; and Medical Applications of Laser-Generated Beams of Particles III. vol. 9514, 951417. https://doi.org/10.1117/12.2178837

Laser-wakefield accelerators for medical phase contrast imaging: Monte Carlo simulations and experimental studies. / Cipiccia, S.; Reboredo, D.; Vittoria, F. A. et al.
Proceedings of SPIE: Laser Acceleration of Electrons, Protons, and Ions III; and Medical Applications of Laser-Generated Beams of Particles III. ed. / Kenneth W. D. Ledingham; Eric Esarey; Klaus Spohr; Carl B. Schroeder; Paul McKenna; Florian J. Grüner; Paul R. Bolton. Vol. 9514 2015. 951417.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution book

TY - GEN

T1 - Laser-wakefield accelerators for medical phase contrast imaging

T2 - Monte Carlo simulations and experimental studies

AU - Cipiccia, S.

AU - Reboredo, D.

AU - Vittoria, F. A.

AU - Welsh, G. H.

AU - Grant, P.

AU - Grant, D. W.

AU - Brunetti, E.

AU - Wiggins, S. M.

AU - Olivo, A.

AU - Jaroszynski, D. A.

N1 - Copyright 2015 Society of Photo-Optical Instrumentation Engineers. One print or electronic copy may be made for personal use only. Systematic reproduction and distribution, duplication of any materi al in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited.

PY - 2015/4/13

Y1 - 2015/4/13

N2 - X-ray phase contrast imaging (X-PCi) is a very promising method of dramatically enhancing the contrast of X-ray images of microscopic weakly absorbing objects and soft tissue, which may lead to significant advancement in medical imaging with high-resolution and low-dose. The interest in X-PCi is giving rise to a demand for effective simulation methods. Monte Carlo codes have been proved a valuable tool for studying X-PCi including coherent effects. The laser-plasma wakefield accelerators (LWFA) is a very compact particle accelerator that uses plasma as an accelerating medium. Accelerating gradient in excess of 1 GV/cm can be obtained, which makes them over a thousand times more compact than conventional accelerators. LWFA are also sources of brilliant betatron radiation, which are promising for applications including medical imaging. We present a study that explores the potential of LWFA-based betatron sources for medical X-PCi and investigate its resolution limit using numerical simulations based on the FLUKA Monte Carlo code, and present preliminary experimental results

AB - X-ray phase contrast imaging (X-PCi) is a very promising method of dramatically enhancing the contrast of X-ray images of microscopic weakly absorbing objects and soft tissue, which may lead to significant advancement in medical imaging with high-resolution and low-dose. The interest in X-PCi is giving rise to a demand for effective simulation methods. Monte Carlo codes have been proved a valuable tool for studying X-PCi including coherent effects. The laser-plasma wakefield accelerators (LWFA) is a very compact particle accelerator that uses plasma as an accelerating medium. Accelerating gradient in excess of 1 GV/cm can be obtained, which makes them over a thousand times more compact than conventional accelerators. LWFA are also sources of brilliant betatron radiation, which are promising for applications including medical imaging. We present a study that explores the potential of LWFA-based betatron sources for medical X-PCi and investigate its resolution limit using numerical simulations based on the FLUKA Monte Carlo code, and present preliminary experimental results

KW - lasers

KW - phase contrast

KW - simulations

KW - plasmas

KW - medical imaging

KW - X-raya

KW - numerical simulation

KW - partical accelerators

KW - radiation

KW - tissues

U2 - 10.1117/12.2178837

DO - 10.1117/12.2178837

M3 - Conference contribution book

SN - 9781628416350

VL - 9514

BT - Proceedings of SPIE

A2 - Ledingham, Kenneth W. D.

A2 - Esarey, Eric

A2 - Spohr, Klaus

A2 - Schroeder, Carl B.

A2 - McKenna, Paul

A2 - Grüner, Florian J.

A2 - Bolton, Paul R.

ER -

Cipiccia S, Reboredo D, Vittoria FA, Welsh GH, Grant P, Grant DW et al. Laser-wakefield accelerators for medical phase contrast imaging: Monte Carlo simulations and experimental studies. In Ledingham KWD, Esarey E, Spohr K, Schroeder CB, McKenna P, Grüner FJ, Bolton PR, editors, Proceedings of SPIE: Laser Acceleration of Electrons, Protons, and Ions III; and Medical Applications of Laser-Generated Beams of Particles III. Vol. 9514. 2015. 951417 doi: 10.1117/12.2178837

Laser-wakefield accelerators for medical phase contrast imaging: Monte Carlo simulations and experimental studies

Abstract

Keywords

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Projects

University Of Strathclyde - Equipment Account

EUCARD2

LASERLAB-EUROPE

Equipment

ARCHIE-WeSt (UOSHPC)

Cite this