Laser-driven very high energy electron/photon beam radiation therapy in conjunction with a robotic system

Kazuhisa Nakajima, Jianjun Yuan, Liming Chen, Zhengming Sheng

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

We present a new external-beam radiation therapy system using very-high-energy (VHE) electron/photon beams generated by a centimeter-scale laser plasma accelerator built in a robotic system. Most types of external-beam radiation therapy are delivered using a machine called a medical linear accelerator driven by radio frequency (RF) power amplifiers, producing electron beams with an energy range of 6-20 MeV, in conjunction with modern radiation therapy technologies for effective shaping of three-dimensional dose distributions and spatially accurate dose delivery with imaging verification. However, the limited penetration depth and low quality of the transverse penumbra at such electron beams delivered from the present RF linear accelerators prevent the implementation of advanced modalities in current cancer treatments. These drawbacks can be overcome if the electron energy is increased to above 50 MeV. To overcome the disadvantages of the present RF-based medical accelerators, harnessing recent advancement of laser-driven plasma accelerators capable of producing 1-GeV electron beams in a 1-cm gas cell, we propose a new embodiment of the external-beam radiation therapy robotic system delivering very high-energy electron/photon beams with an energy of 50-250 MeV; it is more compact, less expensive, and has a simpler operation and higher performance in comparison with the current radiation therapy system.

LanguageEnglish
Pages1-20
Number of pages20
JournalApplied Sciences
Volume5
Issue number1
Early online date29 Dec 2014
DOIs
Publication statusPublished - 31 Mar 2015

Fingerprint

photon beams
Radiotherapy
robotics
high energy electrons
radiation therapy
Robotics
Photons
electron beams
Plasma accelerators
Electrons
Lasers
plasma accelerators
Electron beams
radio frequencies
Linear accelerators
lasers
linear accelerators
Radio frequency amplifiers
penumbras
dosage

Keywords

  • external-beam radiation therapy
  • laser plasma accelerators
  • robotic system
  • very-high-energy electron beam cancer therapy

Cite this

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abstract = "We present a new external-beam radiation therapy system using very-high-energy (VHE) electron/photon beams generated by a centimeter-scale laser plasma accelerator built in a robotic system. Most types of external-beam radiation therapy are delivered using a machine called a medical linear accelerator driven by radio frequency (RF) power amplifiers, producing electron beams with an energy range of 6-20 MeV, in conjunction with modern radiation therapy technologies for effective shaping of three-dimensional dose distributions and spatially accurate dose delivery with imaging verification. However, the limited penetration depth and low quality of the transverse penumbra at such electron beams delivered from the present RF linear accelerators prevent the implementation of advanced modalities in current cancer treatments. These drawbacks can be overcome if the electron energy is increased to above 50 MeV. To overcome the disadvantages of the present RF-based medical accelerators, harnessing recent advancement of laser-driven plasma accelerators capable of producing 1-GeV electron beams in a 1-cm gas cell, we propose a new embodiment of the external-beam radiation therapy robotic system delivering very high-energy electron/photon beams with an energy of 50-250 MeV; it is more compact, less expensive, and has a simpler operation and higher performance in comparison with the current radiation therapy system.",
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Laser-driven very high energy electron/photon beam radiation therapy in conjunction with a robotic system. / Nakajima, Kazuhisa; Yuan, Jianjun; Chen, Liming; Sheng, Zhengming.

In: Applied Sciences, Vol. 5, No. 1, 31.03.2015, p. 1-20.

Research output: Contribution to journalArticle

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