TY - JOUR
T1 - Lanthanide luminescence from supramolecular hydrogels consisting of bio-conjugated picolinic-acid-based guanosine quadruplexes
AU - Kotova, Oxana
AU - O'Reilly, Ciaran
AU - Barwich, Sebastian T.
AU - MacKenzie, Lewis E.
AU - Lynes, Amy D.
AU - Savyasachi, Aramballi J.
AU - Ruether, Manuel
AU - Pal, Robert
AU - Möbius, Matthias E.
AU - Gunnlaugsson, Thorfinnur
PY - 2022/5/12
Y1 - 2022/5/12
N2 - The formation of bio-inspired healable lanthanide luminescent hydrogels is detailed. These materials are composed of K(I)-stabilized guanosine quadruplexes (G4) that were bio-conjugated to mannose-derived picolinic acid ligand 1 using boric acid chemistry (G4-1). The supramolecular self-assembly between G4-1 and europium (Eu(III)) was confirmed, including the use of time-gated luminescence spectroscopy. The most stable hydrogel was formed when the ratio between 1 and Eu(III) was 1:1, and this gel was found to retain a helical column. The obtained gel samples were further characterized using techniques, such as scanning electron microscopy (SEM), circular dichroism (CD), and luminescence spectroscopy. We demonstrate that a Eu(III)-centered circularly polarized luminescence (CPL) signal from guanosine hydrogels can be observed even via long-range interaction, whereas the rheology of these gels exhibits their healable properties.
AB - The formation of bio-inspired healable lanthanide luminescent hydrogels is detailed. These materials are composed of K(I)-stabilized guanosine quadruplexes (G4) that were bio-conjugated to mannose-derived picolinic acid ligand 1 using boric acid chemistry (G4-1). The supramolecular self-assembly between G4-1 and europium (Eu(III)) was confirmed, including the use of time-gated luminescence spectroscopy. The most stable hydrogel was formed when the ratio between 1 and Eu(III) was 1:1, and this gel was found to retain a helical column. The obtained gel samples were further characterized using techniques, such as scanning electron microscopy (SEM), circular dichroism (CD), and luminescence spectroscopy. We demonstrate that a Eu(III)-centered circularly polarized luminescence (CPL) signal from guanosine hydrogels can be observed even via long-range interaction, whereas the rheology of these gels exhibits their healable properties.
KW - lanthanide luminescence
KW - self-assembly
KW - circularly polarized luminescence
KW - supramolecular hydrogels
KW - guanosine quadruplex
KW - picolinic acid ligands
KW - rheology
KW - self-healing
U2 - 10.1016/j.chempr.2022.01.015
DO - 10.1016/j.chempr.2022.01.015
M3 - Article
SN - 2451-9294
VL - 8
SP - 1395
EP - 1414
JO - Chem
JF - Chem
IS - 5
ER -