Lactate concentration in breast cancer using advanced magnetic resonance spectroscopy

Sai Man Cheung, Ehab Husain, Yazan Masannat, Iain D. Miller, Klaus Wahle, Steven D. Heys, Jiabao He

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Abstract

Background: Precision medicine in breast cancer demands markers sensitive to early treatment response. Aerobic glycolysis (AG) upregulates lactate dehydrogenase A (LDH-A) with elevated lactate production; however, existing approaches for lactate quantification are either invasive or impractical clinically. Methods: Thirty female patients (age 39–78 years, 15 grade II and 15 grade III) with invasive ductal carcinoma were enrolled. Lactate concentration was quantified from freshly excised whole tumours with double quantum filtered (DQF) magnetic resonance spectroscopy (MRS), and Nottingham Prognostic Index (NPI), LDH-A and proliferative marker Ki-67 were assessed histologically. Results: There was a significantly higher lactate concentration (t = 2.2224, p = 0.0349) in grade III (7.7 ± 2.9 mM) than in grade II (5.5 ± 2.4 mM). Lactate concentration was correlated with NPI (ρ = 0.3618, p = 0.0495), but not with Ki-67 (ρ = 0.3041, p = 0.1023) or tumour size (r = 0.1716, p = 0.3645). Lactate concentration was negatively correlated with LDH-A (ρ = −0.3734, p = 0.0421). Conclusion: Our results showed that lactate concentration in whole breast tumour from DQF MRS is sensitive to tumour grades and patient prognosis.

Original languageEnglish
Pages (from-to)261-267
Number of pages7
JournalBritish Journal of Cancer
Volume123
Issue number2
Early online date19 May 2020
DOIs
Publication statusPublished - 21 Jul 2020

Keywords

  • lactate concentration
  • breast cancer
  • breast tumour
  • ductal carcinoma

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