Lack of replication for the myosin-18B association with mathematical ability in independent cohorts

K. A. Pettigrew, S. F. Fajutrao Valles, K. Moll, K. Northstone, S. Ring, C. Pennell, C. Wang, R. Leavett, M. E. Hayiou-Thomas, P. Thompson, N. H. Simpson, S. E. Fisher, A. J O Whitehouse, M. J. Snowling, D. F. Newbury, S. Paracchini, R. Nudel, A. P. Monaco, C. Francks, G. Baird & 20 others V. Slonims, K. Dworzynski, P. F. Bolton, E. Simonoff, A. O'Hare, J. Seckl, H. Cowie, A. Clark, J. Watson, J. Nasir, W. Cohen, A. Everitt, E. R. Hennessy, D. Shaw, P. J. Helms, Z. Simkin, G. Conti, D. Ramsden, D. V M Bishop, A. Pickles

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Twin studies indicate that dyscalculia (or mathematical disability) is caused partly by a genetic component, which is yet to be understood at the molecular level. Recently, a coding variant (rs133885) in the myosin-18B gene was shown to be associated with mathematical abilities with a specific effect among children with dyslexia. This association represents one of the most significant genetic associations reported to date for mathematical abilities and the only one reaching genome-wide statistical significance. We conducted a replication study in different cohorts to assess the effect of rs133885 maths-related measures. The study was conducted primarily using the Avon Longitudinal Study of Parents and Children (ALSPAC), (N=3819). We tested additional cohorts including the York Cohort, the Specific Language Impairment Consortium (SLIC) cohort and the Raine Cohort, and stratified them for a definition of dyslexia whenever possible. We did not observe any associations between rs133885 in myosin-18B and mathematical abilities among individuals with dyslexia or in the general population. Our results suggest that the myosin-18B variant is unlikely to be a main factor contributing to mathematical abilities. We could not replicate the association of the myosin-18B gene with mathematical ability.

LanguageEnglish
Pages369-376
Number of pages8
JournalGenes, Brain and Behavior
Volume14
Issue number4
DOIs
Publication statusPublished - 1 Apr 2015

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Aptitude
Myosins
Dyslexia
Dyscalculia
Twin Studies
Genes
Longitudinal Studies
Language
Parents
Genome
Population

Keywords

  • ALSPAC
  • cognitive abilities
  • dyscalculia
  • dyslexia
  • genetic association
  • neurodevelopmental disorders

Cite this

Pettigrew, K. A., Fajutrao Valles, S. F., Moll, K., Northstone, K., Ring, S., Pennell, C., ... Pickles, A. (2015). Lack of replication for the myosin-18B association with mathematical ability in independent cohorts. Genes, Brain and Behavior , 14(4), 369-376. https://doi.org/10.1111/gbb.12213
Pettigrew, K. A. ; Fajutrao Valles, S. F. ; Moll, K. ; Northstone, K. ; Ring, S. ; Pennell, C. ; Wang, C. ; Leavett, R. ; Hayiou-Thomas, M. E. ; Thompson, P. ; Simpson, N. H. ; Fisher, S. E. ; Whitehouse, A. J O ; Snowling, M. J. ; Newbury, D. F. ; Paracchini, S. ; Nudel, R. ; Monaco, A. P. ; Francks, C. ; Baird, G. ; Slonims, V. ; Dworzynski, K. ; Bolton, P. F. ; Simonoff, E. ; O'Hare, A. ; Seckl, J. ; Cowie, H. ; Clark, A. ; Watson, J. ; Nasir, J. ; Cohen, W. ; Everitt, A. ; Hennessy, E. R. ; Shaw, D. ; Helms, P. J. ; Simkin, Z. ; Conti, G. ; Ramsden, D. ; Bishop, D. V M ; Pickles, A. / Lack of replication for the myosin-18B association with mathematical ability in independent cohorts. In: Genes, Brain and Behavior . 2015 ; Vol. 14, No. 4. pp. 369-376.
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Pettigrew, KA, Fajutrao Valles, SF, Moll, K, Northstone, K, Ring, S, Pennell, C, Wang, C, Leavett, R, Hayiou-Thomas, ME, Thompson, P, Simpson, NH, Fisher, SE, Whitehouse, AJO, Snowling, MJ, Newbury, DF, Paracchini, S, Nudel, R, Monaco, AP, Francks, C, Baird, G, Slonims, V, Dworzynski, K, Bolton, PF, Simonoff, E, O'Hare, A, Seckl, J, Cowie, H, Clark, A, Watson, J, Nasir, J, Cohen, W, Everitt, A, Hennessy, ER, Shaw, D, Helms, PJ, Simkin, Z, Conti, G, Ramsden, D, Bishop, DVM & Pickles, A 2015, 'Lack of replication for the myosin-18B association with mathematical ability in independent cohorts' Genes, Brain and Behavior , vol. 14, no. 4, pp. 369-376. https://doi.org/10.1111/gbb.12213

Lack of replication for the myosin-18B association with mathematical ability in independent cohorts. / Pettigrew, K. A.; Fajutrao Valles, S. F.; Moll, K.; Northstone, K.; Ring, S.; Pennell, C.; Wang, C.; Leavett, R.; Hayiou-Thomas, M. E.; Thompson, P.; Simpson, N. H.; Fisher, S. E.; Whitehouse, A. J O; Snowling, M. J.; Newbury, D. F.; Paracchini, S.; Nudel, R.; Monaco, A. P.; Francks, C.; Baird, G.; Slonims, V.; Dworzynski, K.; Bolton, P. F.; Simonoff, E.; O'Hare, A.; Seckl, J.; Cowie, H.; Clark, A.; Watson, J.; Nasir, J.; Cohen, W.; Everitt, A.; Hennessy, E. R.; Shaw, D.; Helms, P. J.; Simkin, Z.; Conti, G.; Ramsden, D.; Bishop, D. V M; Pickles, A.

In: Genes, Brain and Behavior , Vol. 14, No. 4, 01.04.2015, p. 369-376.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Lack of replication for the myosin-18B association with mathematical ability in independent cohorts

AU - Pettigrew, K. A.

AU - Fajutrao Valles, S. F.

AU - Moll, K.

AU - Northstone, K.

AU - Ring, S.

AU - Pennell, C.

AU - Wang, C.

AU - Leavett, R.

AU - Hayiou-Thomas, M. E.

AU - Thompson, P.

AU - Simpson, N. H.

AU - Fisher, S. E.

AU - Whitehouse, A. J O

AU - Snowling, M. J.

AU - Newbury, D. F.

AU - Paracchini, S.

AU - Nudel, R.

AU - Monaco, A. P.

AU - Francks, C.

AU - Baird, G.

AU - Slonims, V.

AU - Dworzynski, K.

AU - Bolton, P. F.

AU - Simonoff, E.

AU - O'Hare, A.

AU - Seckl, J.

AU - Cowie, H.

AU - Clark, A.

AU - Watson, J.

AU - Nasir, J.

AU - Cohen, W.

AU - Everitt, A.

AU - Hennessy, E. R.

AU - Shaw, D.

AU - Helms, P. J.

AU - Simkin, Z.

AU - Conti, G.

AU - Ramsden, D.

AU - Bishop, D. V M

AU - Pickles, A.

PY - 2015/4/1

Y1 - 2015/4/1

N2 - Twin studies indicate that dyscalculia (or mathematical disability) is caused partly by a genetic component, which is yet to be understood at the molecular level. Recently, a coding variant (rs133885) in the myosin-18B gene was shown to be associated with mathematical abilities with a specific effect among children with dyslexia. This association represents one of the most significant genetic associations reported to date for mathematical abilities and the only one reaching genome-wide statistical significance. We conducted a replication study in different cohorts to assess the effect of rs133885 maths-related measures. The study was conducted primarily using the Avon Longitudinal Study of Parents and Children (ALSPAC), (N=3819). We tested additional cohorts including the York Cohort, the Specific Language Impairment Consortium (SLIC) cohort and the Raine Cohort, and stratified them for a definition of dyslexia whenever possible. We did not observe any associations between rs133885 in myosin-18B and mathematical abilities among individuals with dyslexia or in the general population. Our results suggest that the myosin-18B variant is unlikely to be a main factor contributing to mathematical abilities. We could not replicate the association of the myosin-18B gene with mathematical ability.

AB - Twin studies indicate that dyscalculia (or mathematical disability) is caused partly by a genetic component, which is yet to be understood at the molecular level. Recently, a coding variant (rs133885) in the myosin-18B gene was shown to be associated with mathematical abilities with a specific effect among children with dyslexia. This association represents one of the most significant genetic associations reported to date for mathematical abilities and the only one reaching genome-wide statistical significance. We conducted a replication study in different cohorts to assess the effect of rs133885 maths-related measures. The study was conducted primarily using the Avon Longitudinal Study of Parents and Children (ALSPAC), (N=3819). We tested additional cohorts including the York Cohort, the Specific Language Impairment Consortium (SLIC) cohort and the Raine Cohort, and stratified them for a definition of dyslexia whenever possible. We did not observe any associations between rs133885 in myosin-18B and mathematical abilities among individuals with dyslexia or in the general population. Our results suggest that the myosin-18B variant is unlikely to be a main factor contributing to mathematical abilities. We could not replicate the association of the myosin-18B gene with mathematical ability.

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KW - cognitive abilities

KW - dyscalculia

KW - dyslexia

KW - genetic association

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Pettigrew KA, Fajutrao Valles SF, Moll K, Northstone K, Ring S, Pennell C et al. Lack of replication for the myosin-18B association with mathematical ability in independent cohorts. Genes, Brain and Behavior . 2015 Apr 1;14(4):369-376. https://doi.org/10.1111/gbb.12213