Lack of effect of proteinase-activated receptor 2 (PAR2) deletion on the pathophysiological changes produced by lipopolysaccharide in the mouse:comparison with dexamethasone

H. Kazerani, R.J. Plevin, J. Kawagoe, T. Kanke, B.L. Furman

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Four pentacyclic tritepenes were isolated from Combretum imberbe Engl. & Diels, of which two are novel glycosidic derivatives of 1α,3β,23-trihydroxyolean-12-en-29-oic acid (hydroxyimberbic acid). Terminalia stuhlmannii Engl. & Diels stem bark yielded two glycosides of hydroxyimberbic acid, one of which is reported for the first time. The structures of the isolated compounds were elucidated by spectroscopic methods. Several of the compounds had antibacterial activity, imberbic acid showing particularly potent activity against Mycobacterium fortuitum and Staphylococcus aureus.
LanguageEnglish
Pages1015-20
Number of pages6
JournalJournal of Pharmacy and Pharmacology
Volume56
Issue number8
DOIs
Publication statusPublished - 2004

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PAR-2 Receptor
Dexamethasone
Lipopolysaccharides
Acids
Combretum
Mycobacterium fortuitum
Terminalia
Glycosides
Staphylococcus aureus

Keywords

  • proteinase-activated receptor-2
  • lipopolysaccharide
  • dexamethasone

Cite this

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title = "Lack of effect of proteinase-activated receptor 2 (PAR2) deletion on the pathophysiological changes produced by lipopolysaccharide in the mouse:comparison with dexamethasone",
abstract = "Four pentacyclic tritepenes were isolated from Combretum imberbe Engl. & Diels, of which two are novel glycosidic derivatives of 1α,3β,23-trihydroxyolean-12-en-29-oic acid (hydroxyimberbic acid). Terminalia stuhlmannii Engl. & Diels stem bark yielded two glycosides of hydroxyimberbic acid, one of which is reported for the first time. The structures of the isolated compounds were elucidated by spectroscopic methods. Several of the compounds had antibacterial activity, imberbic acid showing particularly potent activity against Mycobacterium fortuitum and Staphylococcus aureus.",
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T1 - Lack of effect of proteinase-activated receptor 2 (PAR2) deletion on the pathophysiological changes produced by lipopolysaccharide in the mouse:comparison with dexamethasone

AU - Kazerani, H.

AU - Plevin, R.J.

AU - Kawagoe, J.

AU - Kanke, T.

AU - Furman, B.L.

PY - 2004

Y1 - 2004

N2 - Four pentacyclic tritepenes were isolated from Combretum imberbe Engl. & Diels, of which two are novel glycosidic derivatives of 1α,3β,23-trihydroxyolean-12-en-29-oic acid (hydroxyimberbic acid). Terminalia stuhlmannii Engl. & Diels stem bark yielded two glycosides of hydroxyimberbic acid, one of which is reported for the first time. The structures of the isolated compounds were elucidated by spectroscopic methods. Several of the compounds had antibacterial activity, imberbic acid showing particularly potent activity against Mycobacterium fortuitum and Staphylococcus aureus.

AB - Four pentacyclic tritepenes were isolated from Combretum imberbe Engl. & Diels, of which two are novel glycosidic derivatives of 1α,3β,23-trihydroxyolean-12-en-29-oic acid (hydroxyimberbic acid). Terminalia stuhlmannii Engl. & Diels stem bark yielded two glycosides of hydroxyimberbic acid, one of which is reported for the first time. The structures of the isolated compounds were elucidated by spectroscopic methods. Several of the compounds had antibacterial activity, imberbic acid showing particularly potent activity against Mycobacterium fortuitum and Staphylococcus aureus.

KW - proteinase-activated receptor-2

KW - lipopolysaccharide

KW - dexamethasone

U2 - 10.1211/0022357043923

DO - 10.1211/0022357043923

M3 - Article

VL - 56

SP - 1015

EP - 1020

JO - Journal of Pharmacy and Pharmacology

T2 - Journal of Pharmacy and Pharmacology

JF - Journal of Pharmacy and Pharmacology

SN - 0022-3573

IS - 8

ER -