Label-free detection of amyloid growth with microcantilever sensors

T. P J Knowles, Wenmiao Shu, François Huber, Hans Peter Lang, Christoph Gerber, Christopher M. Dobson, Mark E. Welland

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

We present an approach for sensing protein aggregation using microcantilever systems. Results from both single cantilever experiments with internal reference and multicantilever array measurements with dedicated reference cantilevers are discussed. We show that in both cases protein aggregation on the sensor can be detected through associated changes in surface stress.
Original languageEnglish
Article number384007
Number of pages5
JournalNanotechnology
Volume19
Issue number38
DOIs
Publication statusPublished - 1 Sep 2008

Keywords

  • protein aggregation
  • multicantilever array measurements
  • Alzheimer disease
  • Parkinson Disease

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