Kahalalide derivatives from the Indian sacoglossan mollusk Elysia grandifolia

Mohamed Ashour, RuAngelie Edrada, Rainer Ebel, Victor Wray, Wim Wätjen, K Padmakumar, Werner E G Müller, Wen Han Lin, Peter Proksch, Ruangelie Edrada-Ebel

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99 Citations (Scopus)

Abstract

Two new cyclic depsipeptide derivatives, kahalalides R (1) and S (2), together with two known congeners, kahalalides F (3) and D (4), were isolated from the Indian sacoglossan mollusk Elysia grandifolia. The structures of the new compounds were unambiguously established on the basis of NMR spectroscopic (1H, 13C, COSY, HMBC) and mass spectrometric (FABMS, ESIMS, MALDI-TOF/PSD) data, which also included Marfey amino acid analyses. The new derivative kahalalide R was found to exert comparable or even higher cytotoxicity than the potential drug candidate kahalalide F toward the MCF7 human mammary carcinoma cell line.

Original languageEnglish
Pages (from-to)1547-1553
Number of pages7
JournalJournal of Natural Products
Volume69
Issue number11
DOIs
Publication statusPublished - Nov 2006

Keywords

  • animals
  • antineoplastic agents
  • cell line, tumor
  • depsipeptides
  • drug screening assays, antitumor
  • Indian Ocean
  • mammary neoplasms
  • molecular structure
  • mollusca
  • nuclear magnetic resonance, Biomolecular

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  • Cite this

    Ashour, M., Edrada, R., Ebel, R., Wray, V., Wätjen, W., Padmakumar, K., Müller, W. E. G., Lin, W. H., Proksch, P., & Edrada-Ebel, R. (2006). Kahalalide derivatives from the Indian sacoglossan mollusk Elysia grandifolia. Journal of Natural Products, 69(11), 1547-1553. https://doi.org/10.1021/np060172v