Abstract
Two new cyclic depsipeptide derivatives, kahalalides R (1) and S (2), together with two known congeners, kahalalides F (3) and D (4), were isolated from the Indian sacoglossan mollusk Elysia grandifolia. The structures of the new compounds were unambiguously established on the basis of NMR spectroscopic (1H, 13C, COSY, HMBC) and mass spectrometric (FABMS, ESIMS, MALDI-TOF/PSD) data, which also included Marfey amino acid analyses. The new derivative kahalalide R was found to exert comparable or even higher cytotoxicity than the potential drug candidate kahalalide F toward the MCF7 human mammary carcinoma cell line.
Original language | English |
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Pages (from-to) | 1547-1553 |
Number of pages | 7 |
Journal | Journal of Natural Products |
Volume | 69 |
Issue number | 11 |
DOIs | |
Publication status | Published - Nov 2006 |
Keywords
- animals
- antineoplastic agents
- cell line, tumor
- depsipeptides
- drug screening assays, antitumor
- Indian Ocean
- mammary neoplasms
- molecular structure
- mollusca
- nuclear magnetic resonance, Biomolecular