Janus-dendrimer supramolecular structures as delivery agents for small molecules, peptides and proteins

Luis Bimbo, Sami Nummelin, Markus Selin, Jarmo Ropponen, Sacha Legrand, Jill Deleu, Ville Liljeström, Antti Nykänen, Jari Koivisto, Manu Lahtinen, Jouni Hirvonen, Leena Peltonen, Tapani Viitala, Jani Seitsonen, Mauri Kostiainen

Research output: Contribution to conferencePoster

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Abstract

Janus-dendrimers are synthetic amphiphiles formed by linking two chemically distinct hydrophilic and hydrophobic dendrons by their core, which can self-assemble as vesicles (dendrimersomes) or fibres in aqueous solutions, as well as in biological media. This research shows that the dendrimersome scan differentially encapsulate drug compounds, are stable for long periods of time, and can be annealed from 22 °C to 70 °C with minimal change (2-5 nm)in their hydrodynamic radius [1].Also, by modulating the hydrophilic branch generation we found that Janus-dendrimers were also able to self-assemble into a variety of other architectures such as fibres, giving rise to supramolecular hydrogels capable of encapsulating and releasing small molecules, peptides, and proteins[2],or even function as colloidal suspensions’ stabilizers [3].Thus, the small library of Janus-dendrimers reported herein expand the scope of dendrimer-based supramolecular drug delivery systems and suggest that these materials can be further used in biomedical sol–gel applications.
Original languageEnglish
Number of pages2
Publication statusPublished - 22 Jul 2019
EventCRS Annual Meeting and Exposition - palacio de Congresos de Valencia, Valencia, Spain
Duration: 21 Jul 201924 Jul 2019
https://2019.controlledreleasesociety.org/

Conference

ConferenceCRS Annual Meeting and Exposition
CountrySpain
CityValencia
Period21/07/1924/07/19
Internet address

Keywords

  • dendrons
  • Janus dendrimers
  • drug delivery
  • hydrogels

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    Bimbo, L., Nummelin, S., Selin, M., Ropponen, J., Legrand, S., Deleu, J., ... Kostiainen, M. (2019). Janus-dendrimer supramolecular structures as delivery agents for small molecules, peptides and proteins. Poster session presented at CRS Annual Meeting and Exposition , Valencia, Spain.