Janus-dendrimer supramolecular structures as delivery agents for small molecules, peptides and proteins

Luis Bimbo, Sami Nummelin, Markus Selin, Jarmo Ropponen, Sacha Legrand, Jill Deleu, Ville Liljeström, Antti Nykänen, Jari Koivisto, Manu Lahtinen, Jouni Hirvonen, Leena Peltonen, Tapani Viitala, Jani Seitsonen, Mauri Kostiainen

Research output: Contribution to conferencePoster

Abstract

Janus-dendrimers are synthetic amphiphiles formed by linking two chemically distinct hydrophilic and hydrophobic dendrons by their core, which can self-assemble as vesicles (dendrimersomes) or fibres in aqueous solutions, as well as in biological media. This research shows that the dendrimersome scan differentially encapsulate drug compounds, are stable for long periods of time, and can be annealed from 22 °C to 70 °C with minimal change (2-5 nm)in their hydrodynamic radius [1].Also, by modulating the hydrophilic branch generation we found that Janus-dendrimers were also able to self-assemble into a variety of other architectures such as fibres, giving rise to supramolecular hydrogels capable of encapsulating and releasing small molecules, peptides, and proteins[2],or even function as colloidal suspensions’ stabilizers [3].Thus, the small library of Janus-dendrimers reported herein expand the scope of dendrimer-based supramolecular drug delivery systems and suggest that these materials can be further used in biomedical sol–gel applications.

Conference

ConferenceCRS Annual Meeting and Exposition
CountrySpain
CityValencia
Period21/07/1924/07/19
Internet address

Fingerprint

Dendrimers
Peptides
Proteins
Hydrogels
Polymethyl Methacrylate
Hydrodynamics
Drug Delivery Systems
Libraries
Suspensions
Gels
Research
Pharmaceutical Preparations

Keywords

  • dendrons
  • Janus dendrimers
  • drug delivery
  • hydrogels

Cite this

Bimbo, L., Nummelin, S., Selin, M., Ropponen, J., Legrand, S., Deleu, J., ... Kostiainen, M. (2019). Janus-dendrimer supramolecular structures as delivery agents for small molecules, peptides and proteins. Poster session presented at CRS Annual Meeting and Exposition , Valencia, Spain.
Bimbo, Luis ; Nummelin, Sami ; Selin, Markus ; Ropponen, Jarmo ; Legrand, Sacha ; Deleu, Jill ; Liljeström, Ville ; Nykänen, Antti ; Koivisto, Jari ; Lahtinen, Manu ; Hirvonen, Jouni ; Peltonen, Leena ; Viitala, Tapani ; Seitsonen, Jani ; Kostiainen, Mauri. / Janus-dendrimer supramolecular structures as delivery agents for small molecules, peptides and proteins. Poster session presented at CRS Annual Meeting and Exposition , Valencia, Spain.2 p.
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title = "Janus-dendrimer supramolecular structures as delivery agents for small molecules, peptides and proteins",
abstract = "Janus-dendrimers are synthetic amphiphiles formed by linking two chemically distinct hydrophilic and hydrophobic dendrons by their core, which can self-assemble as vesicles (dendrimersomes) or fibres in aqueous solutions, as well as in biological media. This research shows that the dendrimersome scan differentially encapsulate drug compounds, are stable for long periods of time, and can be annealed from 22 °C to 70 °C with minimal change (2-5 nm)in their hydrodynamic radius [1].Also, by modulating the hydrophilic branch generation we found that Janus-dendrimers were also able to self-assemble into a variety of other architectures such as fibres, giving rise to supramolecular hydrogels capable of encapsulating and releasing small molecules, peptides, and proteins[2],or even function as colloidal suspensions’ stabilizers [3].Thus, the small library of Janus-dendrimers reported herein expand the scope of dendrimer-based supramolecular drug delivery systems and suggest that these materials can be further used in biomedical sol–gel applications.",
keywords = "dendrons, Janus dendrimers, drug delivery, hydrogels",
author = "Luis Bimbo and Sami Nummelin and Markus Selin and Jarmo Ropponen and Sacha Legrand and Jill Deleu and Ville Liljestr{\"o}m and Antti Nyk{\"a}nen and Jari Koivisto and Manu Lahtinen and Jouni Hirvonen and Leena Peltonen and Tapani Viitala and Jani Seitsonen and Mauri Kostiainen",
year = "2019",
month = "7",
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language = "English",
note = "CRS Annual Meeting and Exposition ; Conference date: 21-07-2019 Through 24-07-2019",
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Bimbo, L, Nummelin, S, Selin, M, Ropponen, J, Legrand, S, Deleu, J, Liljeström, V, Nykänen, A, Koivisto, J, Lahtinen, M, Hirvonen, J, Peltonen, L, Viitala, T, Seitsonen, J & Kostiainen, M 2019, 'Janus-dendrimer supramolecular structures as delivery agents for small molecules, peptides and proteins' CRS Annual Meeting and Exposition , Valencia, Spain, 21/07/19 - 24/07/19, .

Janus-dendrimer supramolecular structures as delivery agents for small molecules, peptides and proteins. / Bimbo, Luis; Nummelin, Sami; Selin, Markus; Ropponen, Jarmo; Legrand, Sacha; Deleu, Jill; Liljeström, Ville; Nykänen, Antti; Koivisto, Jari; Lahtinen, Manu ; Hirvonen, Jouni; Peltonen, Leena; Viitala, Tapani; Seitsonen, Jani; Kostiainen, Mauri.

2019. Poster session presented at CRS Annual Meeting and Exposition , Valencia, Spain.

Research output: Contribution to conferencePoster

TY - CONF

T1 - Janus-dendrimer supramolecular structures as delivery agents for small molecules, peptides and proteins

AU - Bimbo, Luis

AU - Nummelin, Sami

AU - Selin, Markus

AU - Ropponen, Jarmo

AU - Legrand, Sacha

AU - Deleu, Jill

AU - Liljeström, Ville

AU - Nykänen, Antti

AU - Koivisto, Jari

AU - Lahtinen, Manu

AU - Hirvonen, Jouni

AU - Peltonen, Leena

AU - Viitala, Tapani

AU - Seitsonen, Jani

AU - Kostiainen, Mauri

PY - 2019/7/22

Y1 - 2019/7/22

N2 - Janus-dendrimers are synthetic amphiphiles formed by linking two chemically distinct hydrophilic and hydrophobic dendrons by their core, which can self-assemble as vesicles (dendrimersomes) or fibres in aqueous solutions, as well as in biological media. This research shows that the dendrimersome scan differentially encapsulate drug compounds, are stable for long periods of time, and can be annealed from 22 °C to 70 °C with minimal change (2-5 nm)in their hydrodynamic radius [1].Also, by modulating the hydrophilic branch generation we found that Janus-dendrimers were also able to self-assemble into a variety of other architectures such as fibres, giving rise to supramolecular hydrogels capable of encapsulating and releasing small molecules, peptides, and proteins[2],or even function as colloidal suspensions’ stabilizers [3].Thus, the small library of Janus-dendrimers reported herein expand the scope of dendrimer-based supramolecular drug delivery systems and suggest that these materials can be further used in biomedical sol–gel applications.

AB - Janus-dendrimers are synthetic amphiphiles formed by linking two chemically distinct hydrophilic and hydrophobic dendrons by their core, which can self-assemble as vesicles (dendrimersomes) or fibres in aqueous solutions, as well as in biological media. This research shows that the dendrimersome scan differentially encapsulate drug compounds, are stable for long periods of time, and can be annealed from 22 °C to 70 °C with minimal change (2-5 nm)in their hydrodynamic radius [1].Also, by modulating the hydrophilic branch generation we found that Janus-dendrimers were also able to self-assemble into a variety of other architectures such as fibres, giving rise to supramolecular hydrogels capable of encapsulating and releasing small molecules, peptides, and proteins[2],or even function as colloidal suspensions’ stabilizers [3].Thus, the small library of Janus-dendrimers reported herein expand the scope of dendrimer-based supramolecular drug delivery systems and suggest that these materials can be further used in biomedical sol–gel applications.

KW - dendrons

KW - Janus dendrimers

KW - drug delivery

KW - hydrogels

UR - https://2019.controlledreleasesociety.org/

M3 - Poster

ER -

Bimbo L, Nummelin S, Selin M, Ropponen J, Legrand S, Deleu J et al. Janus-dendrimer supramolecular structures as delivery agents for small molecules, peptides and proteins. 2019. Poster session presented at CRS Annual Meeting and Exposition , Valencia, Spain.