Abstract
| Language | English |
|---|---|
| Number of pages | 2 |
| Publication status | Published - 22 Jul 2019 |
| Event | CRS Annual Meeting and Exposition - palacio de Congresos de Valencia, Valencia, Spain Duration: 21 Jul 2019 → 24 Jul 2019 https://2019.controlledreleasesociety.org/ |
Conference
| Conference | CRS Annual Meeting and Exposition |
|---|---|
| Country | Spain |
| City | Valencia |
| Period | 21/07/19 → 24/07/19 |
| Internet address |
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Keywords
- dendrons
- Janus dendrimers
- drug delivery
- hydrogels
Cite this
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Janus-dendrimer supramolecular structures as delivery agents for small molecules, peptides and proteins. / Bimbo, Luis; Nummelin, Sami; Selin, Markus; Ropponen, Jarmo; Legrand, Sacha; Deleu, Jill; Liljeström, Ville; Nykänen, Antti; Koivisto, Jari; Lahtinen, Manu ; Hirvonen, Jouni; Peltonen, Leena; Viitala, Tapani; Seitsonen, Jani; Kostiainen, Mauri.
2019. Poster session presented at CRS Annual Meeting and Exposition , Valencia, Spain.Research output: Contribution to conference › Poster
TY - CONF
T1 - Janus-dendrimer supramolecular structures as delivery agents for small molecules, peptides and proteins
AU - Bimbo, Luis
AU - Nummelin, Sami
AU - Selin, Markus
AU - Ropponen, Jarmo
AU - Legrand, Sacha
AU - Deleu, Jill
AU - Liljeström, Ville
AU - Nykänen, Antti
AU - Koivisto, Jari
AU - Lahtinen, Manu
AU - Hirvonen, Jouni
AU - Peltonen, Leena
AU - Viitala, Tapani
AU - Seitsonen, Jani
AU - Kostiainen, Mauri
PY - 2019/7/22
Y1 - 2019/7/22
N2 - Janus-dendrimers are synthetic amphiphiles formed by linking two chemically distinct hydrophilic and hydrophobic dendrons by their core, which can self-assemble as vesicles (dendrimersomes) or fibres in aqueous solutions, as well as in biological media. This research shows that the dendrimersome scan differentially encapsulate drug compounds, are stable for long periods of time, and can be annealed from 22 °C to 70 °C with minimal change (2-5 nm)in their hydrodynamic radius [1].Also, by modulating the hydrophilic branch generation we found that Janus-dendrimers were also able to self-assemble into a variety of other architectures such as fibres, giving rise to supramolecular hydrogels capable of encapsulating and releasing small molecules, peptides, and proteins[2],or even function as colloidal suspensions’ stabilizers [3].Thus, the small library of Janus-dendrimers reported herein expand the scope of dendrimer-based supramolecular drug delivery systems and suggest that these materials can be further used in biomedical sol–gel applications.
AB - Janus-dendrimers are synthetic amphiphiles formed by linking two chemically distinct hydrophilic and hydrophobic dendrons by their core, which can self-assemble as vesicles (dendrimersomes) or fibres in aqueous solutions, as well as in biological media. This research shows that the dendrimersome scan differentially encapsulate drug compounds, are stable for long periods of time, and can be annealed from 22 °C to 70 °C with minimal change (2-5 nm)in their hydrodynamic radius [1].Also, by modulating the hydrophilic branch generation we found that Janus-dendrimers were also able to self-assemble into a variety of other architectures such as fibres, giving rise to supramolecular hydrogels capable of encapsulating and releasing small molecules, peptides, and proteins[2],or even function as colloidal suspensions’ stabilizers [3].Thus, the small library of Janus-dendrimers reported herein expand the scope of dendrimer-based supramolecular drug delivery systems and suggest that these materials can be further used in biomedical sol–gel applications.
KW - dendrons
KW - Janus dendrimers
KW - drug delivery
KW - hydrogels
UR - https://2019.controlledreleasesociety.org/
M3 - Poster
ER -