Isotopic labelling of functionalised arenes catalysed by Ir(I) species of the [(COD)Ir(NHC)(py)]PF6 complex class

William Kerr, Laura Paterson, John Herbert, Alan McNeill, Paul Cross

Research output: Contribution to journalArticle

14 Citations (Scopus)
65 Downloads (Pure)

Abstract

Ir(I) complexes of the type [(COD)Ir(NHC)(Py)]PF6 have been exposed as efficient catalysts in the area of hydrogen isotope exchange. More specifically, via an ortho-directed C-H activation process, high levels of deuterium incorporation have been achieved using low levels of catalyst over a range of functionalised aromatic compounds. Additionally, the developed protocol has been extended to include a selected pharmacological target, where chemoselective labelling is observed within such a multifunctional substrate.
Original languageEnglish
Pages (from-to)111-115
Number of pages4
JournalSynlett
Volume27
Issue number1
Early online date28 Oct 2015
DOIs
Publication statusE-pub ahead of print - 28 Oct 2015

Keywords

  • iridium
  • C-H activation
  • hydrogen isotope exchange
  • deuteration

Fingerprint Dive into the research topics of 'Isotopic labelling of functionalised arenes catalysed by Ir(I) species of the [(COD)Ir(NHC)(py)]PF6 complex class'. Together they form a unique fingerprint.

  • Cite this