Isotopic labelling of functionalised arenes catalysed by Ir(I) species of the [(COD)Ir(NHC)(py)]PF6 complex class

William Kerr, Laura Paterson, John Herbert, Alan McNeill, Paul Cross

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Ir(I) complexes of the type [(COD)Ir(NHC)(Py)]PF6 have been exposed as efficient catalysts in the area of hydrogen isotope exchange. More specifically, via an ortho-directed C-H activation process, high levels of deuterium incorporation have been achieved using low levels of catalyst over a range of functionalised aromatic compounds. Additionally, the developed protocol has been extended to include a selected pharmacological target, where chemoselective labelling is observed within such a multifunctional substrate.
LanguageEnglish
Pages111-115
Number of pages4
JournalSynlett
Volume27
Issue number1
Early online date28 Oct 2015
DOIs
Publication statusE-pub ahead of print - 28 Oct 2015

Fingerprint

Labeling
Catalysts
Aromatic compounds
Deuterium
Isotopes
Hydrogen
Chemical activation
Substrates

Keywords

  • iridium
  • C-H activation
  • hydrogen isotope exchange
  • deuteration

Cite this

Kerr, William ; Paterson, Laura ; Herbert, John ; McNeill, Alan ; Cross, Paul. / Isotopic labelling of functionalised arenes catalysed by Ir(I) species of the [(COD)Ir(NHC)(py)]PF6 complex class. In: Synlett. 2015 ; Vol. 27, No. 1. pp. 111-115.
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Isotopic labelling of functionalised arenes catalysed by Ir(I) species of the [(COD)Ir(NHC)(py)]PF6 complex class. / Kerr, William; Paterson, Laura; Herbert, John; McNeill, Alan; Cross, Paul.

In: Synlett, Vol. 27, No. 1, 28.10.2015, p. 111-115.

Research output: Contribution to journalArticle

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