Isolation of diterpenes and flavonoids from a new type of propolis from Saudi Arabia

Sultan Almutairi; Ruangelie Edrada-Ebel; James Fearnley; John O. Igoli; Waqas Alotaibi; Carol J. Clements; Alexander I. Gray; David G. Watson

doi:10.1016/j.phytol.2014.08.022

Isolation of diterpenes and flavonoids from a new type of propolis from Saudi Arabia

Sultan Almutairi, Ruangelie Edrada-Ebel, James Fearnley, John O. Igoli, Waqas Alotaibi, Carol J. Clements, Alexander I. Gray, David G. Watson^*

^*Corresponding author for this work

Strathclyde Institute Of Pharmacy And Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

27 Citations (Scopus)

Abstract

The chemical composition and biological activity of a sample of Saudi Arabian propolis were investigated. A new diterpene propsiadin ((ent)-2-oxo-kaur-16-en-6,18-diol) (3) along with the flavonoids 3,4-dihydro-2-(3,4-dihydroxyphenyl)-2H-chromene-3,7-diol (1), psiadiarabin (2) and the diterpene psiadin (4) were isolated from a Saudi Arabian propolis. Their structures were determined by HR-ESI-MS, 1D and 2D NMR. Compound 1 was inactive against Trypanosoma brucei and Mycobacterium marinum while compounds 2-4 had MICs of 30.9, 78.1 and 78.1 μM against T. brucei respectively and 312.1, 312.1 and 69.1 μM against M. marinum. The likely sources of the propolis are Psiadia arabica and Psiadia punctulata and it represents a new type of propolis not described before.

Original language	English
Pages (from-to)	160-163
Number of pages	4
Journal	Phytochemistry Letters
Volume	10
Early online date	16 Sept 2014
DOIs	https://doi.org/10.1016/j.phytol.2014.08.022
Publication status	Published - 31 Dec 2014

Keywords

antitrypanosomal activity
diterpenes
flavonoids
propolis
psiadia arabica
Saudi Arabia

Access to Document

10.1016/j.phytol.2014.08.022

Cite this

@article{115ded9c15da4ba6aa2745b15aff6b89,

title = "Isolation of diterpenes and flavonoids from a new type of propolis from Saudi Arabia",

abstract = "The chemical composition and biological activity of a sample of Saudi Arabian propolis were investigated. A new diterpene propsiadin ((ent)-2-oxo-kaur-16-en-6,18-diol) (3) along with the flavonoids 3,4-dihydro-2-(3,4-dihydroxyphenyl)-2H-chromene-3,7-diol (1), psiadiarabin (2) and the diterpene psiadin (4) were isolated from a Saudi Arabian propolis. Their structures were determined by HR-ESI-MS, 1D and 2D NMR. Compound 1 was inactive against Trypanosoma brucei and Mycobacterium marinum while compounds 2-4 had MICs of 30.9, 78.1 and 78.1 μM against T. brucei respectively and 312.1, 312.1 and 69.1 μM against M. marinum. The likely sources of the propolis are Psiadia arabica and Psiadia punctulata and it represents a new type of propolis not described before.",

keywords = "antitrypanosomal activity, diterpenes, flavonoids, propolis, psiadia arabica, Saudi Arabia",

author = "Sultan Almutairi and Ruangelie Edrada-Ebel and James Fearnley and Igoli, {John O.} and Waqas Alotaibi and Clements, {Carol J.} and Gray, {Alexander I.} and Watson, {David G.}",

year = "2014",

month = dec,

day = "31",

doi = "10.1016/j.phytol.2014.08.022",

language = "English",

volume = "10",

pages = "160--163",

journal = "Phytochemistry Letters",

issn = "1874-3900",

}

TY - JOUR

T1 - Isolation of diterpenes and flavonoids from a new type of propolis from Saudi Arabia

AU - Almutairi, Sultan

AU - Edrada-Ebel, Ruangelie

AU - Fearnley, James

AU - Igoli, John O.

AU - Alotaibi, Waqas

AU - Clements, Carol J.

AU - Gray, Alexander I.

AU - Watson, David G.

PY - 2014/12/31

Y1 - 2014/12/31

N2 - The chemical composition and biological activity of a sample of Saudi Arabian propolis were investigated. A new diterpene propsiadin ((ent)-2-oxo-kaur-16-en-6,18-diol) (3) along with the flavonoids 3,4-dihydro-2-(3,4-dihydroxyphenyl)-2H-chromene-3,7-diol (1), psiadiarabin (2) and the diterpene psiadin (4) were isolated from a Saudi Arabian propolis. Their structures were determined by HR-ESI-MS, 1D and 2D NMR. Compound 1 was inactive against Trypanosoma brucei and Mycobacterium marinum while compounds 2-4 had MICs of 30.9, 78.1 and 78.1 μM against T. brucei respectively and 312.1, 312.1 and 69.1 μM against M. marinum. The likely sources of the propolis are Psiadia arabica and Psiadia punctulata and it represents a new type of propolis not described before.

AB - The chemical composition and biological activity of a sample of Saudi Arabian propolis were investigated. A new diterpene propsiadin ((ent)-2-oxo-kaur-16-en-6,18-diol) (3) along with the flavonoids 3,4-dihydro-2-(3,4-dihydroxyphenyl)-2H-chromene-3,7-diol (1), psiadiarabin (2) and the diterpene psiadin (4) were isolated from a Saudi Arabian propolis. Their structures were determined by HR-ESI-MS, 1D and 2D NMR. Compound 1 was inactive against Trypanosoma brucei and Mycobacterium marinum while compounds 2-4 had MICs of 30.9, 78.1 and 78.1 μM against T. brucei respectively and 312.1, 312.1 and 69.1 μM against M. marinum. The likely sources of the propolis are Psiadia arabica and Psiadia punctulata and it represents a new type of propolis not described before.

KW - antitrypanosomal activity

KW - diterpenes

KW - flavonoids

KW - propolis

KW - psiadia arabica

KW - Saudi Arabia

UR - http://www.scopus.com/inward/record.url?scp=84907788985&partnerID=8YFLogxK

U2 - 10.1016/j.phytol.2014.08.022

DO - 10.1016/j.phytol.2014.08.022

M3 - Article

AN - SCOPUS:84907788985

SN - 1874-3900

VL - 10

SP - 160

EP - 163

JO - Phytochemistry Letters

JF - Phytochemistry Letters

ER -

Isolation of diterpenes and flavonoids from a new type of propolis from Saudi Arabia

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Libyan propolis raw data

Cite this

Isolation of diterpenes and flavonoids from a new type of propolis from Saudi Arabia

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Datasets

Libyan propolis raw data

Cite this