Isolation and structure elucidation of ardisenone: a new, cytotoxic alkenylphenol from Ardisia iwahigensis

F D Horgen; H Guinaudeau; J M Pezzuto; D D Soejarto; N R Farnsworth; F Agcaoili; G de los Reyes; R A Edrada; Ruangelie Edrada-Ebel

doi:10.1021/np970049r

Isolation and structure elucidation of ardisenone: a new, cytotoxic alkenylphenol from Ardisia iwahigensis

F D Horgen, H Guinaudeau, J M Pezzuto, D D Soejarto, N R Farnsworth, F Agcaoili, G de los Reyes, R A Edrada, Ruangelie Edrada-Ebel

Strathclyde Institute Of Pharmacy And Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

26 Citations (Scopus)

Abstract

A methanol extract of leaves and twigs from Ardisia iwahigensis demonstrated toxicity toward brine shrimp as well as LNCaP, ZR-75-1, and Lu1 human cancer cells in culture. A novel alkenylphenol, (Z)-1,16-bis(3-hydroxy-5-methoxyphenyl)-10-hexadecene-1,15-dione (ardisenone) (1), was isolated from the extract by bioassay-directed fractionation. This compound demonstrated moderate cytotoxicity against BC1, Lu1, Col2, KB, KB-V1, and LNCaP cell lines.

Original language	English
Pages (from-to)	533-535
Number of pages	3
Journal	Journal of Natural Products
Volume	60
Issue number	5
Early online date	22 May 1997
DOIs	https://doi.org/10.1021/np970049r
Publication status	Published - May 1997

Keywords

animals
anisoles
antineoplastic agents, phytogenic
artemia
drug screening assays, antitumor
humans
magnetic resonance spectroscopy
plant extracts
plants, Medicinal
spectrophotometry, infrared
tumor cells, cultured

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title = "Isolation and structure elucidation of ardisenone: a new, cytotoxic alkenylphenol from Ardisia iwahigensis",

abstract = "A methanol extract of leaves and twigs from Ardisia iwahigensis demonstrated toxicity toward brine shrimp as well as LNCaP, ZR-75-1, and Lu1 human cancer cells in culture. A novel alkenylphenol, (Z)-1,16-bis(3-hydroxy-5-methoxyphenyl)-10-hexadecene-1,15-dione (ardisenone) (1), was isolated from the extract by bioassay-directed fractionation. This compound demonstrated moderate cytotoxicity against BC1, Lu1, Col2, KB, KB-V1, and LNCaP cell lines.",

keywords = "animals, anisoles, antineoplastic agents, phytogenic, artemia, drug screening assays, antitumor, humans, magnetic resonance spectroscopy, plant extracts, plants, Medicinal, spectrophotometry, infrared, tumor cells, cultured",

author = "Horgen, {F D} and H Guinaudeau and Pezzuto, {J M} and Soejarto, {D D} and Farnsworth, {N R} and F Agcaoili and {de los Reyes}, G and Edrada, {R A} and Ruangelie Edrada-Ebel",

year = "1997",

month = may,

doi = "10.1021/np970049r",

language = "English",

volume = "60",

pages = "533--535",

journal = "Journal of Natural Products",

issn = "0163-3864",

publisher = "American Chemical Society",

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T1 - Isolation and structure elucidation of ardisenone

T2 - a new, cytotoxic alkenylphenol from Ardisia iwahigensis

AU - Horgen, F D

AU - Guinaudeau, H

AU - Pezzuto, J M

AU - Soejarto, D D

AU - Farnsworth, N R

AU - Agcaoili, F

AU - de los Reyes, G

AU - Edrada, R A

AU - Edrada-Ebel, Ruangelie

PY - 1997/5

Y1 - 1997/5

N2 - A methanol extract of leaves and twigs from Ardisia iwahigensis demonstrated toxicity toward brine shrimp as well as LNCaP, ZR-75-1, and Lu1 human cancer cells in culture. A novel alkenylphenol, (Z)-1,16-bis(3-hydroxy-5-methoxyphenyl)-10-hexadecene-1,15-dione (ardisenone) (1), was isolated from the extract by bioassay-directed fractionation. This compound demonstrated moderate cytotoxicity against BC1, Lu1, Col2, KB, KB-V1, and LNCaP cell lines.

AB - A methanol extract of leaves and twigs from Ardisia iwahigensis demonstrated toxicity toward brine shrimp as well as LNCaP, ZR-75-1, and Lu1 human cancer cells in culture. A novel alkenylphenol, (Z)-1,16-bis(3-hydroxy-5-methoxyphenyl)-10-hexadecene-1,15-dione (ardisenone) (1), was isolated from the extract by bioassay-directed fractionation. This compound demonstrated moderate cytotoxicity against BC1, Lu1, Col2, KB, KB-V1, and LNCaP cell lines.

KW - animals

KW - anisoles

KW - antineoplastic agents, phytogenic

KW - artemia

KW - drug screening assays, antitumor

KW - humans

KW - magnetic resonance spectroscopy

KW - plant extracts

KW - plants, Medicinal

KW - spectrophotometry, infrared

KW - tumor cells, cultured

U2 - 10.1021/np970049r

DO - 10.1021/np970049r

M3 - Article

C2 - 9170297

SN - 0163-3864

VL - 60

SP - 533

EP - 535

JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 5

ER -

Isolation and structure elucidation of ardisenone: a new, cytotoxic alkenylphenol from Ardisia iwahigensis

Abstract

Keywords

UN SDGs

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