Isolation and identification of antitrypanosomal and antimycobacterial active steroids from the sponge haliclona simulans

Christina Viegelmann, Jennifer Parker, Thengtheng Ooi, Carol Clements, Gráinne Abbott, Louise Young, Jonathan Kennedy, Alan D W Dobson, RuAngelie Edrada-Ebel

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

The marine sponge Haliclona simulans collected from the Irish Sea yielded two new steroids: 24-vinyl-cholest-9-ene-3β,24-diol and 20-methyl-pregn-6-en-3β-ol,5a,8a-epidioxy, along with the widely distributed 24-methylenecholesterol. One of the steroids possesses an unusually short hydrocarbon side chain. The structures were elucidated using nuclear magnetic resonance spectroscopy and confirmed using electron impact- and high resolution electrospray-mass spectrometry. All three steroids possess antitrypanosomal and anti-mycobacterial activity. All the steroids were found to possess low cytotoxicity against Hs27 which was above their detected antitrypanosomal potent concentrations.

LanguageEnglish
Pages2937-2952
Number of pages16
JournalMarine Drugs
Volume12
Issue number5
DOIs
Publication statusPublished - 16 May 2014

Fingerprint

Haliclona
Porifera
Steroids
Hydrocarbons
Oceans and Seas
Mass Spectrometry
Magnetic Resonance Spectroscopy
Electrons

Keywords

  • haliclona simulans
  • marine sponges
  • steroids
  • antitrypanosomal
  • anti-mycobacterial

Cite this

Viegelmann, Christina ; Parker, Jennifer ; Ooi, Thengtheng ; Clements, Carol ; Abbott, Gráinne ; Young, Louise ; Kennedy, Jonathan ; Dobson, Alan D W ; Edrada-Ebel, RuAngelie. / Isolation and identification of antitrypanosomal and antimycobacterial active steroids from the sponge haliclona simulans. In: Marine Drugs. 2014 ; Vol. 12, No. 5. pp. 2937-2952.
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Isolation and identification of antitrypanosomal and antimycobacterial active steroids from the sponge haliclona simulans. / Viegelmann, Christina; Parker, Jennifer; Ooi, Thengtheng; Clements, Carol; Abbott, Gráinne; Young, Louise; Kennedy, Jonathan; Dobson, Alan D W; Edrada-Ebel, RuAngelie.

In: Marine Drugs, Vol. 12, No. 5, 16.05.2014, p. 2937-2952.

Research output: Contribution to journalArticle

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AU - Viegelmann, Christina

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AU - Abbott, Gráinne

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AU - Dobson, Alan D W

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