Isolation and identification of antitrypanosomal and antimycobacterial active steroids from the sponge haliclona simulans

Christina Viegelmann, Jennifer Parker, Thengtheng Ooi, Carol Clements, Gráinne Abbott, Louise Young, Jonathan Kennedy, Alan D W Dobson, RuAngelie Edrada-Ebel

Research output: Contribution to journalArticle

25 Citations (Scopus)
71 Downloads (Pure)

Abstract

The marine sponge Haliclona simulans collected from the Irish Sea yielded two new steroids: 24-vinyl-cholest-9-ene-3β,24-diol and 20-methyl-pregn-6-en-3β-ol,5a,8a-epidioxy, along with the widely distributed 24-methylenecholesterol. One of the steroids possesses an unusually short hydrocarbon side chain. The structures were elucidated using nuclear magnetic resonance spectroscopy and confirmed using electron impact- and high resolution electrospray-mass spectrometry. All three steroids possess antitrypanosomal and anti-mycobacterial activity. All the steroids were found to possess low cytotoxicity against Hs27 which was above their detected antitrypanosomal potent concentrations.

Original languageEnglish
Pages (from-to)2937-2952
Number of pages16
JournalMarine Drugs
Volume12
Issue number5
DOIs
Publication statusPublished - 16 May 2014

Keywords

  • haliclona simulans
  • marine sponges
  • steroids
  • antitrypanosomal
  • anti-mycobacterial

Research Output

  • 25 Citations
  • 1 Poster

Metabolomics as a tool in the identification and production of new antibiotics from sponges and endosymbiotic bacteria

Viegelmann, C. V., Hoe Leong, C., Clements, C., Abdelmohsen, U. R., Hentschel, U., Margassery, L. M., Kennedy, J., Perrocco, D., Dobson, A. D. W. & Edrada-Ebel, R., Feb 2013.

Research output: Contribution to conferencePoster

Activities

  • 1 Hosting an academic visitor

Burkhardt Flemer

Ruangelie Edrada-Ebel (Host)

1 Aug 201121 Aug 2011

Activity: Hosting a visitor typesHosting an academic visitor

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