Research Output per year
The marine sponge Haliclona simulans collected from the Irish Sea yielded two new steroids: 24-vinyl-cholest-9-ene-3β,24-diol and 20-methyl-pregn-6-en-3β-ol,5a,8a-epidioxy, along with the widely distributed 24-methylenecholesterol. One of the steroids possesses an unusually short hydrocarbon side chain. The structures were elucidated using nuclear magnetic resonance spectroscopy and confirmed using electron impact- and high resolution electrospray-mass spectrometry. All three steroids possess antitrypanosomal and anti-mycobacterial activity. All the steroids were found to possess low cytotoxicity against Hs27 which was above their detected antitrypanosomal potent concentrations.
- haliclona simulans
- marine sponges
Metabolomics as a tool in the identification and production of new antibiotics from sponges and endosymbiotic bacteriaViegelmann, C. V., Hoe Leong, C., Clements, C., Abdelmohsen, U. R., Hentschel, U., Margassery, L. M., Kennedy, J., Perrocco, D., Dobson, A. D. W. & Edrada-Ebel, R., Feb 2013.
Research output: Contribution to conference › Poster