In addition to the previously isolated phenylpropanoid glycosides verbascoside 1, forsythoside B 2, arenarioside 3 and ballotetroside 4, another four compounds were isolated from generative aerial parts of Ballota nigra: three phenylpropanoid glycosides, alyssonoside 5, lavandulifolioside 6 and angoroside A 7 and a non-glycosidic derivative (+)-(E)-caffeoyl-l-malic acid 8.The antibacterial activity of the five major compounds (1–4 and 8) was tested against Gram-positive and Gram-negative bacteria. Three of them (1–3) exhibited a moderate antimicrobial activity against Proteus mirabilis and Staphylococcusaureus including one methicillin-resistant strain.
- Ballota nigra
- antimicrobial activity
- phenylpropanoid glycosidic esters
- phenylpropanoid non-glycosidic ester
Didry, N., Seidel, V., Dubreuil, L., Tillequin, F., & Bailleul, F. (1999). Isolation and antibacterial activity of phenylpropanoid derivatives from Ballota nigra. Journal of Ethnopharmacology, 67(2), 197-202. https://doi.org/10.1016/S0378-8741(99)00019-7