Isatin thiosemicarbazones promote honeycomb structure formation in spin-coated polymer films: concentration effect and release studies

Veronica García Fernández-Luna, D. Mallinson, P. Alexiou, I. Khadra, A. B. Mullen, M. Pelecanou, M. Sagnou, D. A. Lamprou

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Formation of ordered porous polymer films is one of the techniques currently under investigation for its potential for the manufacturing of coatings with biomedical applications. Aiming for films with improved characteristics against bacterial colonization, poly(methyl methacrylate) (PMMA) and polyurethane (PU) films were formed via the spin coating method on silica wafer (SW) substrates, in the absence or presence of four isatin thiosemicarbazone derivatives (ITSCs) in various concentrations. The resulting films exhibited high hydrophobicity based on contact angle goniometry measurements ranging from minimum water contact angle values of 84.0° ± 4.0 for PMMA and 85.0° ± 0.2 for PU, alone, to a maximum of 129.3° ± 2.6 and 102.1° ± 1.4, respectively, after the addition of an ITSC. Atomic force microscopy revealed rough polymer surfaces with honeycomb structures which are affected by ITSC type and concentration. PMMA films presented a higher density of pores with a smaller pore diameter (280 ± 20 nm) compared to PU films (647 ± 54 nm). A 24 h dissolution study showed a gradual release of ITSC from the PMMA film, in a pH dependent manner, reaching almost completion, while PU showed no detectable release. Overall, PMMA films blended with ITSCs present favourable characteristics for biomedical coating applications.
LanguageEnglish
Pages12945 - 12952
JournalRSC Advances
Volume7
DOIs
Publication statusPublished - 24 Feb 2017

Fingerprint

Isatin
Thiosemicarbazones
Honeycomb structures
Polymer films
Polymethyl Methacrylate
Polymethyl methacrylates
Polyurethanes
Contact angle
Coatings
Spin coating
Hydrophobicity
Angle measurement
Silicon Dioxide
Atomic force microscopy
Polymers
Dissolution
Silica
Derivatives
Water
Substrates

Keywords

  • isatin thiosemicarbazones
  • honeycomb
  • spin-coated polymer films
  • concentration
  • release studies
  • porous polymer films
  • coatings
  • biomedical applications

Cite this

García Fernández-Luna, Veronica ; Mallinson, D. ; Alexiou, P. ; Khadra, I. ; Mullen, A. B. ; Pelecanou, M. ; Sagnou, M. ; Lamprou, D. A. / Isatin thiosemicarbazones promote honeycomb structure formation in spin-coated polymer films : concentration effect and release studies. In: RSC Advances. 2017 ; Vol. 7. pp. 12945 - 12952.
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abstract = "Formation of ordered porous polymer films is one of the techniques currently under investigation for its potential for the manufacturing of coatings with biomedical applications. Aiming for films with improved characteristics against bacterial colonization, poly(methyl methacrylate) (PMMA) and polyurethane (PU) films were formed via the spin coating method on silica wafer (SW) substrates, in the absence or presence of four isatin thiosemicarbazone derivatives (ITSCs) in various concentrations. The resulting films exhibited high hydrophobicity based on contact angle goniometry measurements ranging from minimum water contact angle values of 84.0° ± 4.0 for PMMA and 85.0° ± 0.2 for PU, alone, to a maximum of 129.3° ± 2.6 and 102.1° ± 1.4, respectively, after the addition of an ITSC. Atomic force microscopy revealed rough polymer surfaces with honeycomb structures which are affected by ITSC type and concentration. PMMA films presented a higher density of pores with a smaller pore diameter (280 ± 20 nm) compared to PU films (647 ± 54 nm). A 24 h dissolution study showed a gradual release of ITSC from the PMMA film, in a pH dependent manner, reaching almost completion, while PU showed no detectable release. Overall, PMMA films blended with ITSCs present favourable characteristics for biomedical coating applications.",
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Isatin thiosemicarbazones promote honeycomb structure formation in spin-coated polymer films : concentration effect and release studies. / García Fernández-Luna, Veronica; Mallinson, D.; Alexiou, P.; Khadra, I.; Mullen, A. B.; Pelecanou, M.; Sagnou, M.; Lamprou, D. A.

In: RSC Advances, Vol. 7, 24.02.2017, p. 12945 - 12952.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Isatin thiosemicarbazones promote honeycomb structure formation in spin-coated polymer films

T2 - RSC Advances

AU - García Fernández-Luna, Veronica

AU - Mallinson, D.

AU - Alexiou, P.

AU - Khadra, I.

AU - Mullen, A. B.

AU - Pelecanou, M.

AU - Sagnou, M.

AU - Lamprou, D. A.

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Y1 - 2017/2/24

N2 - Formation of ordered porous polymer films is one of the techniques currently under investigation for its potential for the manufacturing of coatings with biomedical applications. Aiming for films with improved characteristics against bacterial colonization, poly(methyl methacrylate) (PMMA) and polyurethane (PU) films were formed via the spin coating method on silica wafer (SW) substrates, in the absence or presence of four isatin thiosemicarbazone derivatives (ITSCs) in various concentrations. The resulting films exhibited high hydrophobicity based on contact angle goniometry measurements ranging from minimum water contact angle values of 84.0° ± 4.0 for PMMA and 85.0° ± 0.2 for PU, alone, to a maximum of 129.3° ± 2.6 and 102.1° ± 1.4, respectively, after the addition of an ITSC. Atomic force microscopy revealed rough polymer surfaces with honeycomb structures which are affected by ITSC type and concentration. PMMA films presented a higher density of pores with a smaller pore diameter (280 ± 20 nm) compared to PU films (647 ± 54 nm). A 24 h dissolution study showed a gradual release of ITSC from the PMMA film, in a pH dependent manner, reaching almost completion, while PU showed no detectable release. Overall, PMMA films blended with ITSCs present favourable characteristics for biomedical coating applications.

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