Parasympathetic nerves innervate the detrusor muscle of the urinary bladder, but a non-cholinergic component ofneurotransmission was recognised over 100 years ago (Langley & Anderson, 1895). Subsequently, ATP was identified asthe cotransmitter with acetylcholine (Kasakov & Burnstock, 1983). Here we have determined the effects of P2X receptorantagonists on the non-cholinergic component of neurotransmission.
|Publication status||Published - May 2008|
- P2 receptors
- P2X1 subtype
- urinary bladder