Is there a role for P2 receptors other than the P2X1 subtype in parasympathetic cotransmission in the urinary bladder?

C. Kennedy

Is there a role for P2 receptors other than the P2X1 subtype in parasympathetic cotransmission in the urinary bladder?

Strathclyde Institute Of Pharmacy And Biomedical Sciences

Research output: Contribution to journal › Conference Contribution › peer-review

Abstract

Parasympathetic nerves innervate the detrusor muscle of the urinary bladder, but a non-cholinergic component ofneurotransmission was recognised over 100 years ago (Langley & Anderson, 1895). Subsequently, ATP was identified asthe cotransmitter with acetylcholine (Kasakov & Burnstock, 1983). Here we have determined the effects of P2X receptorantagonists on the non-cholinergic component of neurotransmission.

Original language	English
Pages (from-to)	S200-S200
Journal	Purinergic Signalling
Volume	4
Publication status	Published - May 2008

Keywords

P2 receptors
P2X1 subtype
parasympathetic
cotransmission
urinary bladder
acetylcholine

Access to Document

http://dx.doi.org/10.1007/s11302-008-9116-0

Cite this

@article{6094835d48c049f9bcc8a063a0f0771d,

title = "Is there a role for P2 receptors other than the P2X1 subtype in parasympathetic cotransmission in the urinary bladder?",

abstract = "Parasympathetic nerves innervate the detrusor muscle of the urinary bladder, but a non-cholinergic component ofneurotransmission was recognised over 100 years ago (Langley & Anderson, 1895). Subsequently, ATP was identified asthe cotransmitter with acetylcholine (Kasakov & Burnstock, 1983). Here we have determined the effects of P2X receptorantagonists on the non-cholinergic component of neurotransmission.",

keywords = "P2 receptors, P2X1 subtype, parasympathetic, cotransmission, urinary bladder, acetylcholine",

author = "C. Kennedy",

year = "2008",

month = may,

language = "English",

volume = "4",

pages = "S200--S200",