Is there a role for P2 receptors other than the P2X1 subtype in parasympathetic cotransmission in the urinary bladder?

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Parasympathetic nerves innervate the detrusor muscle of the urinary bladder, but a non-cholinergic component ofneurotransmission was recognised over 100 years ago (Langley & Anderson, 1895). Subsequently, ATP was identified asthe cotransmitter with acetylcholine (Kasakov & Burnstock, 1983). Here we have determined the effects of P2X receptorantagonists on the non-cholinergic component of neurotransmission.
Original languageEnglish
Pages (from-to)S200-S200
JournalPurinergic Signalling
Publication statusPublished - May 2008


  • P2 receptors
  • P2X1 subtype
  • parasympathetic
  • cotransmission
  • urinary bladder
  • acetylcholine

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