Is there a role for P2 receptors other than the P2X1 subtype in parasympathetic cotransmission in the urinary bladder?

Research output: Contribution to journalConference Contribution

Abstract

Parasympathetic nerves innervate the detrusor muscle of the urinary bladder, but a non-cholinergic component ofneurotransmission was recognised over 100 years ago (Langley & Anderson, 1895). Subsequently, ATP was identified asthe cotransmitter with acetylcholine (Kasakov & Burnstock, 1983). Here we have determined the effects of P2X receptorantagonists on the non-cholinergic component of neurotransmission.
LanguageEnglish
PagesS200-S200
JournalPurinergic Signalling
Volume4
Publication statusPublished - May 2008

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Purinergic P2X1 Receptors
Synaptic Transmission
Acetylcholine
Urinary Bladder
Adenosine Triphosphate
Muscles

Keywords

  • P2 receptors
  • P2X1 subtype
  • parasympathetic
  • cotransmission
  • urinary bladder
  • acetylcholine

Cite this

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title = "Is there a role for P2 receptors other than the P2X1 subtype in parasympathetic cotransmission in the urinary bladder?",
abstract = "Parasympathetic nerves innervate the detrusor muscle of the urinary bladder, but a non-cholinergic component ofneurotransmission was recognised over 100 years ago (Langley & Anderson, 1895). Subsequently, ATP was identified asthe cotransmitter with acetylcholine (Kasakov & Burnstock, 1983). Here we have determined the effects of P2X receptorantagonists on the non-cholinergic component of neurotransmission.",
keywords = "P2 receptors, P2X1 subtype, parasympathetic, cotransmission, urinary bladder, acetylcholine",
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Is there a role for P2 receptors other than the P2X1 subtype in parasympathetic cotransmission in the urinary bladder? / Kennedy, C.

In: Purinergic Signalling, Vol. 4, 05.2008, p. S200-S200.

Research output: Contribution to journalConference Contribution

TY - JOUR

T1 - Is there a role for P2 receptors other than the P2X1 subtype in parasympathetic cotransmission in the urinary bladder?

AU - Kennedy, C.

PY - 2008/5

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N2 - Parasympathetic nerves innervate the detrusor muscle of the urinary bladder, but a non-cholinergic component ofneurotransmission was recognised over 100 years ago (Langley & Anderson, 1895). Subsequently, ATP was identified asthe cotransmitter with acetylcholine (Kasakov & Burnstock, 1983). Here we have determined the effects of P2X receptorantagonists on the non-cholinergic component of neurotransmission.

AB - Parasympathetic nerves innervate the detrusor muscle of the urinary bladder, but a non-cholinergic component ofneurotransmission was recognised over 100 years ago (Langley & Anderson, 1895). Subsequently, ATP was identified asthe cotransmitter with acetylcholine (Kasakov & Burnstock, 1983). Here we have determined the effects of P2X receptorantagonists on the non-cholinergic component of neurotransmission.

KW - P2 receptors

KW - P2X1 subtype

KW - parasympathetic

KW - cotransmission

KW - urinary bladder

KW - acetylcholine

UR - http://dx.doi.org/10.1007/s11302-008-9116-0

M3 - Conference Contribution

VL - 4

SP - S200-S200

JO - Purinergic Signalling

T2 - Purinergic Signalling

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SN - 1573-9538

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