Iridium-catalyzed formyl-selective deuteration of aldehydes

Research output: Contribution to journalArticle

26 Citations (Scopus)
19 Downloads (Pure)

Abstract

We report the first direct catalytic method for formyl-selective deuterium labeling of aromatic aldehydes under mild conditions, using an iridium-based catalyst designed to favor formyl- over aromatic C-H activation. A good range of aromatic aldehydes is selectively labeled, and a one-pot labeling/olefination protocol is also described. Computational studies support kinetic product control over competing aromatic labeling and decarbonylation pathways.
Original languageEnglish
Pages (from-to)7808–7812
Number of pages5
JournalAngewandte Chemie International Edition
Volume56
Issue number27
Early online date16 May 2017
DOIs
Publication statusPublished - 26 Jun 2017

    Fingerprint

Keywords

  • C-H activation
  • aldehyde
  • iridium catalysis

Cite this