We report the first direct catalytic method for formyl-selective deuterium labeling of aromatic aldehydes under mild conditions, using an iridium-based catalyst designed to favor formyl- over aromatic C-H activation. A good range of aromatic aldehydes is selectively labeled, and a one-pot labeling/olefination protocol is also described. Computational studies support kinetic product control over competing aromatic labeling and decarbonylation pathways.
|Number of pages||5|
|Journal||Angewandte Chemie International Edition|
|Early online date||16 May 2017|
|Publication status||Published - 26 Jun 2017|
- C-H activation
- iridium catalysis