Abstract
We report the first direct catalytic method for formyl-selective deuterium labeling of aromatic aldehydes under mild conditions, using an iridium-based catalyst designed to favor formyl- over aromatic C-H activation. A good range of aromatic aldehydes is selectively labeled, and a one-pot labeling/olefination protocol is also described. Computational studies support kinetic product control over competing aromatic labeling and decarbonylation pathways.
Original language | English |
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Pages (from-to) | 7808–7812 |
Number of pages | 5 |
Journal | Angewandte Chemie International Edition |
Volume | 56 |
Issue number | 27 |
Early online date | 16 May 2017 |
DOIs | |
Publication status | Published - 26 Jun 2017 |
Keywords
- C-H activation
- aldehyde
- iridium catalysis