Abstract
We report the first direct catalytic method for formyl-selective deuterium labeling of aromatic aldehydes under mild conditions, using an iridium-based catalyst designed to favor formyl- over aromatic C-H activation. A good range of aromatic aldehydes is selectively labeled, and a one-pot labeling/olefination protocol is also described. Computational studies support kinetic product control over competing aromatic labeling and decarbonylation pathways.
| Original language | English |
|---|---|
| Pages (from-to) | 7808–7812 |
| Number of pages | 5 |
| Journal | Angewandte Chemie International Edition |
| Volume | 56 |
| Issue number | 27 |
| Early online date | 16 May 2017 |
| DOIs | |
| Publication status | Published - 26 Jun 2017 |
Keywords
- C-H activation
- aldehyde
- iridium catalysis
