Iridium-catalyzed formyl-selective deuteration of aldehydes

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We report the first direct catalytic method for formyl-selective deuterium labeling of aromatic aldehydes under mild conditions, using an iridium-based catalyst designed to favor formyl- over aromatic C-H activation. A good range of aromatic aldehydes is selectively labeled, and a one-pot labeling/olefination protocol is also described. Computational studies support kinetic product control over competing aromatic labeling and decarbonylation pathways.
Original languageEnglish
Pages (from-to)7808–7812
Number of pages5
JournalAngewandte Chemie International Edition
Issue number27
Early online date16 May 2017
Publication statusPublished - 26 Jun 2017


  • C-H activation
  • aldehyde
  • iridium catalysis


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