Iridium Catalysts for Hydrogen Isotope Exchange

Marc Reid

doi:10.1007/3418_2020_58

Iridium Catalysts for Hydrogen Isotope Exchange

Marc Reid^*

^*Corresponding author for this work

Pure And Applied Chemistry

Research output: Chapter in Book/Report/Conference proceeding › Chapter

4 Citations (Scopus)

Abstract

A history and summary of iridium-catalyzed hydrogen isotope exchange (HIE) is described. Owing to the wide range of applications served by installation of heavy and radioactive hydrogen isotopes, a wealth of synthetic labeling strategies have been forthcoming. Principle among all HIE methods are those developed using homogeneous iridium catalysts. This chapter covers major developments in (primarily homogeneous) iridium-centered catalysts for HIE. Connections to the broader fields of hydrogenation and C–H functionalization are also considered.

Original language	English
Title of host publication	Topics in Organometallic Chemistry
Editors	Luis A. Oro, Carmen Claver
Place of Publication	Cham
Publisher	Springer Science and Business Media Deutschland GmbH
Pages	271-302
Number of pages	32
Volume	69
ISBN (Electronic)	9783030690830
ISBN (Print)	9783030690823
DOIs	https://doi.org/10.1007/3418_2020_58
Publication status	Published - 8 Aug 2020

Publication series

Name	Topics in Organometallic Chemistry
Volume	69
ISSN (Print)	1436-6002
ISSN (Electronic)	1616-8534

Funding

Acknowledgments Dr. Marc Reid thanks the Leverhulme Trust for Early Career Fellowship funding (ECF-2016-264) and GlaxoSmithKline for their generous support. Thanks also go to Professor William J. Kerr and Dr. Richard Mudd for useful discussions relating to the preparation of this chapter.

Keywords

C–H functionalization
deuterium
iridium
isotope exchange
tritium
iridium-catalyzed hydrogen isotope exchange (HIE)
catalysis

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10.1007/3418_2020_58

Cite this

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title = "Iridium Catalysts for Hydrogen Isotope Exchange",

abstract = "A history and summary of iridium-catalyzed hydrogen isotope exchange (HIE) is described. Owing to the wide range of applications served by installation of heavy and radioactive hydrogen isotopes, a wealth of synthetic labeling strategies have been forthcoming. Principle among all HIE methods are those developed using homogeneous iridium catalysts. This chapter covers major developments in (primarily homogeneous) iridium-centered catalysts for HIE. Connections to the broader fields of hydrogenation and C–H functionalization are also considered.",

keywords = "C–H functionalization, deuterium, iridium, isotope exchange, tritium, iridium-catalyzed hydrogen isotope exchange (HIE), catalysis",

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note = "Funding Information: Acknowledgments Dr. Marc Reid thanks the Leverhulme Trust for Early Career Fellowship funding (ECF-2016-264) and GlaxoSmithKline for their generous support. Thanks also go to Professor William J. Kerr and Dr. Richard Mudd for useful discussions relating to the preparation of this chapter. Publisher Copyright: {\textcopyright} 2020, The Author(s), under exclusive license to Springer Nature Switzerland AG. Reid, M. (2020). Iridium Catalysts for Hydrogen Isotope Exchange. In: Oro, L.A., Claver, C. (eds) Iridium Catalysts for Organic Reactions. Topics in Organometallic Chemistry, vol 69. Springer, Cham. https://doi.org/10.1007/3418\_2020\_58 The original version of this chapter was revised. A correction to this chapter can be found at https://doi.org/10.1007/3418\_2020\_73",

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AB - A history and summary of iridium-catalyzed hydrogen isotope exchange (HIE) is described. Owing to the wide range of applications served by installation of heavy and radioactive hydrogen isotopes, a wealth of synthetic labeling strategies have been forthcoming. Principle among all HIE methods are those developed using homogeneous iridium catalysts. This chapter covers major developments in (primarily homogeneous) iridium-centered catalysts for HIE. Connections to the broader fields of hydrogenation and C–H functionalization are also considered.

KW - C–H functionalization

KW - deuterium

KW - iridium

KW - isotope exchange

KW - tritium

KW - iridium-catalyzed hydrogen isotope exchange (HIE)

KW - catalysis

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T3 - Topics in Organometallic Chemistry

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BT - Topics in Organometallic Chemistry

A2 - Oro, Luis A.

A2 - Claver, Carmen

PB - Springer Science and Business Media Deutschland GmbH

CY - Cham

ER -

Iridium Catalysts for Hydrogen Isotope Exchange

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