Iridium-catalysed hydrogen isotope exchange for the regioselective deuteration of n-heterocycles

William Kerr, Philippa Kate Owens, Sébastien André Campos

Research output: Contribution to conferenceSpeech

Abstract

Isotopic labelling is an essential tool within the pharmaceutical industry for monitoring the metabolism of potential drug candidates; additionally, demand for deuterated compounds for use in mechanistic studies or as drug targets in their own right is ever-increasing.1 As such, the development of novel, mild, and efficient labelling techniques, which avoid the need for expensive deuterated starting materials, has been the focus of significant attention within the research community. Previous work within our laboratory has involved the development of a novel range of HIE catalysts of the type 1, bearing a combination of bulky phosphine and N-heterocyclic carbene ligands.

Fingerprint

Iridium
Isotopes
Hydrogen
phosphine
Labeling
Bearings (structural)
Pharmaceutical Preparations
Metabolism
Ligands
Catalysts
Monitoring
Industry

Keywords

  • iridium
  • hydrogen isotope exchange
  • regioselective deuteration
  • n-heterocycles
  • isotopic labelling
  • pharmaceutical industry

Cite this

Kerr, W., Owens, P. K., & Campos, S. A. (2015). Iridium-catalysed hydrogen isotope exchange for the regioselective deuteration of n-heterocycles. International Isotope Society, 12th International Symposium on the Synthesis and Application of Isotopically Labelled Compounds, Princeton, United States.
Kerr, William ; Owens, Philippa Kate ; Campos, Sébastien André. / Iridium-catalysed hydrogen isotope exchange for the regioselective deuteration of n-heterocycles. International Isotope Society, 12th International Symposium on the Synthesis and Application of Isotopically Labelled Compounds, Princeton, United States.
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Kerr, W, Owens, PK & Campos, SA 2015, 'Iridium-catalysed hydrogen isotope exchange for the regioselective deuteration of n-heterocycles' International Isotope Society, 12th International Symposium on the Synthesis and Application of Isotopically Labelled Compounds, Princeton, United States, 7/06/15 - 11/06/15, .

Iridium-catalysed hydrogen isotope exchange for the regioselective deuteration of n-heterocycles. / Kerr, William; Owens, Philippa Kate; Campos, Sébastien André.

2015. International Isotope Society, 12th International Symposium on the Synthesis and Application of Isotopically Labelled Compounds, Princeton, United States.

Research output: Contribution to conferenceSpeech

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AU - Owens, Philippa Kate

AU - Campos, Sébastien André

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AB - Isotopic labelling is an essential tool within the pharmaceutical industry for monitoring the metabolism of potential drug candidates; additionally, demand for deuterated compounds for use in mechanistic studies or as drug targets in their own right is ever-increasing.1 As such, the development of novel, mild, and efficient labelling techniques, which avoid the need for expensive deuterated starting materials, has been the focus of significant attention within the research community. Previous work within our laboratory has involved the development of a novel range of HIE catalysts of the type 1, bearing a combination of bulky phosphine and N-heterocyclic carbene ligands.

KW - iridium

KW - hydrogen isotope exchange

KW - regioselective deuteration

KW - n-heterocycles

KW - isotopic labelling

KW - pharmaceutical industry

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Kerr W, Owens PK, Campos SA. Iridium-catalysed hydrogen isotope exchange for the regioselective deuteration of n-heterocycles. 2015. International Isotope Society, 12th International Symposium on the Synthesis and Application of Isotopically Labelled Compounds, Princeton, United States.