Iridium-catalysed hydrogen isotope exchange for the regioselective deuteration of n-heterocycles

William Kerr, Philippa Kate Owens, Sébastien André Campos

Research output: Contribution to conferenceSpeech


Isotopic labelling is an essential tool within the pharmaceutical industry for monitoring the metabolism of potential drug candidates; additionally, demand for deuterated compounds for use in mechanistic studies or as drug targets in their own right is ever-increasing.1 As such, the development of novel, mild, and efficient labelling techniques, which avoid the need for expensive deuterated starting materials, has been the focus of significant attention within the research community. Previous work within our laboratory has involved the development of a novel range of HIE catalysts of the type 1, bearing a combination of bulky phosphine and N-heterocyclic carbene ligands.


ConferenceInternational Isotope Society, 12th International Symposium on the Synthesis and Application of Isotopically Labelled Compounds
Country/TerritoryUnited States
Internet address


  • iridium
  • hydrogen isotope exchange
  • regioselective deuteration
  • n-heterocycles
  • isotopic labelling
  • pharmaceutical industry


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