Ion source development and radiobiology applications within the LIBRA project

M. Borghesi, S. Kar, R. Prasad, F. K. Kakolee, K. Quinn, H. Ahmed, G. Sarri, B. Ramakrishna, B. Qiao, M. Geissler, S. Ter-Avetisyan, M. Zepf, G. Schettino, B. Stevens, M. Tolley, J. Green, P. F. Foster, C. Spindloe, P. Gallegos, A. L. Robinson & 18 others D. Neely, D. C. Carroll, O. Tresca, X. Yuan, M. Quinn, P. McKenna, N. Dover, C. Palmer, J. Schreiber, Z. Najmudin, I. Sari, M. Kraft, M. Merchant, J. C. Jeynes, K. Kirkby, F. Fiorini, D. Kirby, S. Green

Research output: Chapter in Book/Report/Conference proceedingConference contribution book

4 Citations (Scopus)

Abstract

In view of their properties, laser-driven ion beams have the potential to be employed in innovative applications in the scientific, technological and medical areas. Among these, a particularly high-profile application is particle therapy for cancer treatment, which however requires significant improvements from current performances of laser-driven accelerators. The focus of current research in this field is on developing suitable strategies enabling laser-accelerated ions to match these requirements, while exploiting some of the unique features of a laser-driven process. LIBRA is a UK-wide consortium, aiming to address these issues, and develop laser-driven ion sources suitable for applicative purposes, with a particular focus on biomedical applications. We will report on the activities of the consortium aimed to optimizing the properties of the beams, by developing and employing advanced targetry and by exploring novel acceleration regimes enabling production of beams with reduced energy spread. Employing the TARANIS Terawatt laser at Queen's University, we have initiated a campaign investigating the effects of proton irradiation of biological samples at extreme dose rates (> 109 Gy/s).

LanguageEnglish
Title of host publicationLaser Acceleration of Electrons, Protons, and Ions; and Medical Applications of Laser-Generated Secondary Sources of Radiation and Particles
EditorsWim P. Leemans, Eric Esarey, Simon M. Hooker, Kenneth W. D. Ledingham
Place of PublicationBellingham, WA
Volume8079
DOIs
Publication statusPublished - 25 May 2011
EventLaser Acceleration of Electrons, Protons, and Ions; and Medical Applications of Laser-Generated Secondary Sources of Radiation and Particles - Prague, Czech Republic
Duration: 18 Apr 201120 Apr 2011

Conference

ConferenceLaser Acceleration of Electrons, Protons, and Ions; and Medical Applications of Laser-Generated Secondary Sources of Radiation and Particles
CountryCzech Republic
CityPrague
Period18/04/1120/04/11

Fingerprint

radiobiology
Ion sources
ion sources
Laser
Lasers
lasers
Proton irradiation
Biomedical Applications
Oncology
proton irradiation
Accelerator
Irradiation
Ion beams
Therapy
Dosimetry
Particle accelerators
therapy
Dose
Cancer
Extremes

Keywords

  • laser acceleration of ions
  • radiobiology
  • targetry

Cite this

Borghesi, M., Kar, S., Prasad, R., Kakolee, F. K., Quinn, K., Ahmed, H., ... Green, S. (2011). Ion source development and radiobiology applications within the LIBRA project. In W. P. Leemans, E. Esarey, S. M. Hooker, & K. W. D. Ledingham (Eds.), Laser Acceleration of Electrons, Protons, and Ions; and Medical Applications of Laser-Generated Secondary Sources of Radiation and Particles (Vol. 8079). [80791E] Bellingham, WA. https://doi.org/10.1117/12.888262
Borghesi, M. ; Kar, S. ; Prasad, R. ; Kakolee, F. K. ; Quinn, K. ; Ahmed, H. ; Sarri, G. ; Ramakrishna, B. ; Qiao, B. ; Geissler, M. ; Ter-Avetisyan, S. ; Zepf, M. ; Schettino, G. ; Stevens, B. ; Tolley, M. ; Green, J. ; Foster, P. F. ; Spindloe, C. ; Gallegos, P. ; Robinson, A. L. ; Neely, D. ; Carroll, D. C. ; Tresca, O. ; Yuan, X. ; Quinn, M. ; McKenna, P. ; Dover, N. ; Palmer, C. ; Schreiber, J. ; Najmudin, Z. ; Sari, I. ; Kraft, M. ; Merchant, M. ; Jeynes, J. C. ; Kirkby, K. ; Fiorini, F. ; Kirby, D. ; Green, S. / Ion source development and radiobiology applications within the LIBRA project. Laser Acceleration of Electrons, Protons, and Ions; and Medical Applications of Laser-Generated Secondary Sources of Radiation and Particles. editor / Wim P. Leemans ; Eric Esarey ; Simon M. Hooker ; Kenneth W. D. Ledingham. Vol. 8079 Bellingham, WA, 2011.
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abstract = "In view of their properties, laser-driven ion beams have the potential to be employed in innovative applications in the scientific, technological and medical areas. Among these, a particularly high-profile application is particle therapy for cancer treatment, which however requires significant improvements from current performances of laser-driven accelerators. The focus of current research in this field is on developing suitable strategies enabling laser-accelerated ions to match these requirements, while exploiting some of the unique features of a laser-driven process. LIBRA is a UK-wide consortium, aiming to address these issues, and develop laser-driven ion sources suitable for applicative purposes, with a particular focus on biomedical applications. We will report on the activities of the consortium aimed to optimizing the properties of the beams, by developing and employing advanced targetry and by exploring novel acceleration regimes enabling production of beams with reduced energy spread. Employing the TARANIS Terawatt laser at Queen's University, we have initiated a campaign investigating the effects of proton irradiation of biological samples at extreme dose rates (> 109 Gy/s).",
keywords = "laser acceleration of ions, radiobiology, targetry",
author = "M. Borghesi and S. Kar and R. Prasad and Kakolee, {F. K.} and K. Quinn and H. Ahmed and G. Sarri and B. Ramakrishna and B. Qiao and M. Geissler and S. Ter-Avetisyan and M. Zepf and G. Schettino and B. Stevens and M. Tolley and J. Green and Foster, {P. F.} and C. Spindloe and P. Gallegos and Robinson, {A. L.} and D. Neely and Carroll, {D. C.} and O. Tresca and X. Yuan and M. Quinn and P. McKenna and N. Dover and C. Palmer and J. Schreiber and Z. Najmudin and I. Sari and M. Kraft and M. Merchant and Jeynes, {J. C.} and K. Kirkby and F. Fiorini and D. Kirby and S. Green",
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Borghesi, M, Kar, S, Prasad, R, Kakolee, FK, Quinn, K, Ahmed, H, Sarri, G, Ramakrishna, B, Qiao, B, Geissler, M, Ter-Avetisyan, S, Zepf, M, Schettino, G, Stevens, B, Tolley, M, Green, J, Foster, PF, Spindloe, C, Gallegos, P, Robinson, AL, Neely, D, Carroll, DC, Tresca, O, Yuan, X, Quinn, M, McKenna, P, Dover, N, Palmer, C, Schreiber, J, Najmudin, Z, Sari, I, Kraft, M, Merchant, M, Jeynes, JC, Kirkby, K, Fiorini, F, Kirby, D & Green, S 2011, Ion source development and radiobiology applications within the LIBRA project. in WP Leemans, E Esarey, SM Hooker & KWD Ledingham (eds), Laser Acceleration of Electrons, Protons, and Ions; and Medical Applications of Laser-Generated Secondary Sources of Radiation and Particles. vol. 8079, 80791E, Bellingham, WA, Laser Acceleration of Electrons, Protons, and Ions; and Medical Applications of Laser-Generated Secondary Sources of Radiation and Particles, Prague, Czech Republic, 18/04/11. https://doi.org/10.1117/12.888262

Ion source development and radiobiology applications within the LIBRA project. / Borghesi, M.; Kar, S.; Prasad, R.; Kakolee, F. K.; Quinn, K.; Ahmed, H.; Sarri, G.; Ramakrishna, B.; Qiao, B.; Geissler, M.; Ter-Avetisyan, S.; Zepf, M.; Schettino, G.; Stevens, B.; Tolley, M.; Green, J.; Foster, P. F.; Spindloe, C.; Gallegos, P.; Robinson, A. L.; Neely, D.; Carroll, D. C.; Tresca, O.; Yuan, X.; Quinn, M.; McKenna, P.; Dover, N.; Palmer, C.; Schreiber, J.; Najmudin, Z.; Sari, I.; Kraft, M.; Merchant, M.; Jeynes, J. C.; Kirkby, K.; Fiorini, F.; Kirby, D.; Green, S.

Laser Acceleration of Electrons, Protons, and Ions; and Medical Applications of Laser-Generated Secondary Sources of Radiation and Particles. ed. / Wim P. Leemans; Eric Esarey; Simon M. Hooker; Kenneth W. D. Ledingham. Vol. 8079 Bellingham, WA, 2011. 80791E.

Research output: Chapter in Book/Report/Conference proceedingConference contribution book

TY - GEN

T1 - Ion source development and radiobiology applications within the LIBRA project

AU - Borghesi, M.

AU - Kar, S.

AU - Prasad, R.

AU - Kakolee, F. K.

AU - Quinn, K.

AU - Ahmed, H.

AU - Sarri, G.

AU - Ramakrishna, B.

AU - Qiao, B.

AU - Geissler, M.

AU - Ter-Avetisyan, S.

AU - Zepf, M.

AU - Schettino, G.

AU - Stevens, B.

AU - Tolley, M.

AU - Green, J.

AU - Foster, P. F.

AU - Spindloe, C.

AU - Gallegos, P.

AU - Robinson, A. L.

AU - Neely, D.

AU - Carroll, D. C.

AU - Tresca, O.

AU - Yuan, X.

AU - Quinn, M.

AU - McKenna, P.

AU - Dover, N.

AU - Palmer, C.

AU - Schreiber, J.

AU - Najmudin, Z.

AU - Sari, I.

AU - Kraft, M.

AU - Merchant, M.

AU - Jeynes, J. C.

AU - Kirkby, K.

AU - Fiorini, F.

AU - Kirby, D.

AU - Green, S.

PY - 2011/5/25

Y1 - 2011/5/25

N2 - In view of their properties, laser-driven ion beams have the potential to be employed in innovative applications in the scientific, technological and medical areas. Among these, a particularly high-profile application is particle therapy for cancer treatment, which however requires significant improvements from current performances of laser-driven accelerators. The focus of current research in this field is on developing suitable strategies enabling laser-accelerated ions to match these requirements, while exploiting some of the unique features of a laser-driven process. LIBRA is a UK-wide consortium, aiming to address these issues, and develop laser-driven ion sources suitable for applicative purposes, with a particular focus on biomedical applications. We will report on the activities of the consortium aimed to optimizing the properties of the beams, by developing and employing advanced targetry and by exploring novel acceleration regimes enabling production of beams with reduced energy spread. Employing the TARANIS Terawatt laser at Queen's University, we have initiated a campaign investigating the effects of proton irradiation of biological samples at extreme dose rates (> 109 Gy/s).

AB - In view of their properties, laser-driven ion beams have the potential to be employed in innovative applications in the scientific, technological and medical areas. Among these, a particularly high-profile application is particle therapy for cancer treatment, which however requires significant improvements from current performances of laser-driven accelerators. The focus of current research in this field is on developing suitable strategies enabling laser-accelerated ions to match these requirements, while exploiting some of the unique features of a laser-driven process. LIBRA is a UK-wide consortium, aiming to address these issues, and develop laser-driven ion sources suitable for applicative purposes, with a particular focus on biomedical applications. We will report on the activities of the consortium aimed to optimizing the properties of the beams, by developing and employing advanced targetry and by exploring novel acceleration regimes enabling production of beams with reduced energy spread. Employing the TARANIS Terawatt laser at Queen's University, we have initiated a campaign investigating the effects of proton irradiation of biological samples at extreme dose rates (> 109 Gy/s).

KW - laser acceleration of ions

KW - radiobiology

KW - targetry

UR - http://www.scopus.com/inward/record.url?scp=79960088384&partnerID=8YFLogxK

UR - https://www.spiedigitallibrary.org/conference-proceedings-of-spie/8079.toc

U2 - 10.1117/12.888262

DO - 10.1117/12.888262

M3 - Conference contribution book

SN - 9780819486691

VL - 8079

BT - Laser Acceleration of Electrons, Protons, and Ions; and Medical Applications of Laser-Generated Secondary Sources of Radiation and Particles

A2 - Leemans, Wim P.

A2 - Esarey, Eric

A2 - Hooker, Simon M.

A2 - Ledingham, Kenneth W. D.

CY - Bellingham, WA

ER -

Borghesi M, Kar S, Prasad R, Kakolee FK, Quinn K, Ahmed H et al. Ion source development and radiobiology applications within the LIBRA project. In Leemans WP, Esarey E, Hooker SM, Ledingham KWD, editors, Laser Acceleration of Electrons, Protons, and Ions; and Medical Applications of Laser-Generated Secondary Sources of Radiation and Particles. Vol. 8079. Bellingham, WA. 2011. 80791E https://doi.org/10.1117/12.888262