Ion channels in smooth muscle: regulation by the sarcoplasmic reticulum and mitochondria

S. Chalmers, M. Olson, D. MacMillan, R. Rainbow, J.G. McCarron

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

In smooth muscle, Ca2+ regulates cell division, growth and cell death as well as providing the main trigger for contraction. Ion channels provide the major access route to elevate the cytoplasmic Ca2+ concentration ([Ca2+]c) in smooth muscle by permitting Ca2+ entry across the plasma membrane and release of the ion from intracellular Ca2+ stores. The control of [Ca2+]c relies on feedback modulation of the entry and release channels by Ca2+ itself. Local rises in [Ca2+]c may promote or inhibit channel activity directly or indirectly. The latter may arise from Ca2+ regulation of ionic conductances in the plasma membrane to provide control of cell excitability and so [Ca2+]c entry. Organelles such as mitochondria may also contribute significantly to the feedback regulation of ion channel activity by the control of Ca2+ or redox status of the cell. This brief review describes the feedback regulation of Ca2+ release from the internal Ca2+ store and of plasma membrane excitability in smooth muscle.
LanguageEnglish
Pages447-466
Number of pages19
JournalCell Calcium
Volume42
Issue number4-5
DOIs
Publication statusPublished - 13 Jul 2007

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Sarcoplasmic Reticulum
Ion Channels
Smooth Muscle
Mitochondria
Cell Membrane
Organelles
Cell Division
Oxidation-Reduction
Cell Death
Ions
Growth

Keywords

  • smooth muscle
  • calcium
  • ion channels
  • calmodulin

Cite this

Chalmers, S. ; Olson, M. ; MacMillan, D. ; Rainbow, R. ; McCarron, J.G. / Ion channels in smooth muscle: regulation by the sarcoplasmic reticulum and mitochondria. In: Cell Calcium. 2007 ; Vol. 42, No. 4-5. pp. 447-466.
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Ion channels in smooth muscle: regulation by the sarcoplasmic reticulum and mitochondria. / Chalmers, S.; Olson, M.; MacMillan, D.; Rainbow, R.; McCarron, J.G.

In: Cell Calcium, Vol. 42, No. 4-5, 13.07.2007, p. 447-466.

Research output: Contribution to journalArticle

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AU - Olson, M.

AU - MacMillan, D.

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AB - In smooth muscle, Ca2+ regulates cell division, growth and cell death as well as providing the main trigger for contraction. Ion channels provide the major access route to elevate the cytoplasmic Ca2+ concentration ([Ca2+]c) in smooth muscle by permitting Ca2+ entry across the plasma membrane and release of the ion from intracellular Ca2+ stores. The control of [Ca2+]c relies on feedback modulation of the entry and release channels by Ca2+ itself. Local rises in [Ca2+]c may promote or inhibit channel activity directly or indirectly. The latter may arise from Ca2+ regulation of ionic conductances in the plasma membrane to provide control of cell excitability and so [Ca2+]c entry. Organelles such as mitochondria may also contribute significantly to the feedback regulation of ion channel activity by the control of Ca2+ or redox status of the cell. This brief review describes the feedback regulation of Ca2+ release from the internal Ca2+ store and of plasma membrane excitability in smooth muscle.

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