Investigation of formulation and process of lyophilised orally disintegrating tablet (ODT) using novel amino acid combination

Farhan AlHusban, Amr M. Elshaer, Jiteen H. Kansara, Alan M. Smith, Liam M. Grover, Yvonne Perrie, Afzal-Ur-Rahman Mohammed

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Lyophilised orally disintegrating tablets (ODTs) have achieved a great success in overcoming dysphagia associated with conventional solid dosage forms. However, the extensive use of saccharides within the formulation limits their use in treatment of chronic illnesses. The current study demonstrates the feasibility of using combination of proline and serine to formulate zero sacharide ODTs and investigates the effect of freezing protocol on sublimation rate and tablets characteristics. The results showed that inclusion of proline and serine improved ODT properties when compared to individual counterparts. Additionally, annealing the ODTs facilitated the sublimation process and shortened the disintegration time.
LanguageEnglish
Pages1-17
Number of pages17
JournalPharmaceutics
Volume2
Issue number1
DOIs
Publication statusPublished - 1 Jan 2010

Fingerprint

Tablets
Amino Acids
Sublimation
Proline
Serine
Dosage Forms
Feasibility Studies
Deglutition Disorders
Freezing
Chronic Disease

Keywords

  • orally disintegrating tablet
  • proline
  • serine
  • lyophilisation
  • annealing
  • sublimination rate

Cite this

AlHusban, Farhan ; Elshaer, Amr M. ; Kansara, Jiteen H. ; Smith, Alan M. ; Grover, Liam M. ; Perrie, Yvonne ; Mohammed, Afzal-Ur-Rahman. / Investigation of formulation and process of lyophilised orally disintegrating tablet (ODT) using novel amino acid combination. In: Pharmaceutics. 2010 ; Vol. 2, No. 1. pp. 1-17.
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Investigation of formulation and process of lyophilised orally disintegrating tablet (ODT) using novel amino acid combination. / AlHusban, Farhan; Elshaer, Amr M.; Kansara, Jiteen H.; Smith, Alan M.; Grover, Liam M.; Perrie, Yvonne; Mohammed, Afzal-Ur-Rahman.

In: Pharmaceutics, Vol. 2, No. 1, 01.01.2010, p. 1-17.

Research output: Contribution to journalArticle

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